Clonal Propagation of Primate Offspring by Embryo Splitting
Primates that are identical in both nuclear and cytoplasmic components have not been produced by current cloning strategies, yet such identicals represent the ideal model for investigations of human diseases. Here, genetically identical nonhuman embryos were produced as twin and larger sets by separ...
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| Veröffentlicht in: | Science (American Association for the Advancement of Science) 2000-01, Vol.287 (5451), p.317-319 |
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| creator | Chan, A. W. S. Dominko, T. Luetjens, C. M. Neuber, E. Martinovich, C. Hewitson, L. Simerly, C. R. Schatten, G. P. |
| description | Primates that are identical in both nuclear and cytoplasmic components have not been produced by current cloning strategies, yet such identicals represent the ideal model for investigations of human diseases. Here, genetically identical nonhuman embryos were produced as twin and larger sets by separation and reaggregation of blastomeres of cleavage-stage embryos. A total of 368 multiples were created by the splitting of 107 rhesus embryos with four pregnancies established after 13 embryo transfers (31% versus 53% in vitro fertilization controls). The birth of Tetra, a healthy female cloned from a quarter of an embryo, proves that this approach can result in live offspring. |
| doi_str_mv | 10.1126/science.287.5451.317 |
| format | Article |
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W. S. ; Dominko, T. ; Luetjens, C. M. ; Neuber, E. ; Martinovich, C. ; Hewitson, L. ; Simerly, C. R. ; Schatten, G. P.</creator><creatorcontrib>Chan, A. W. S. ; Dominko, T. ; Luetjens, C. M. ; Neuber, E. ; Martinovich, C. ; Hewitson, L. ; Simerly, C. R. ; Schatten, G. P.</creatorcontrib><description>Primates that are identical in both nuclear and cytoplasmic components have not been produced by current cloning strategies, yet such identicals represent the ideal model for investigations of human diseases. Here, genetically identical nonhuman embryos were produced as twin and larger sets by separation and reaggregation of blastomeres of cleavage-stage embryos. A total of 368 multiples were created by the splitting of 107 rhesus embryos with four pregnancies established after 13 embryo transfers (31% versus 53% in vitro fertilization controls). The birth of Tetra, a healthy female cloned from a quarter of an embryo, proves that this approach can result in live offspring.</description><identifier>ISSN: 0036-8075</identifier><identifier>EISSN: 1095-9203</identifier><identifier>DOI: 10.1126/science.287.5451.317</identifier><identifier>PMID: 10634789</identifier><identifier>CODEN: SCIEAS</identifier><language>eng</language><publisher>Washington, DC: American Society for the Advancement of Science</publisher><subject>Animals ; Apoptosis ; Biological and medical sciences ; Blastocyst ; Blastocyst - physiology ; Blastomeres ; Blastomeres - physiology ; Body Weight ; Classical genetics, quantitative genetics, hybrids ; Cleavage Stage, Ovum - physiology ; Cloning ; Cloning, Organism - methods ; Embryo Transfer ; Embryonic and Fetal Development ; Embryonic cells ; Embryonic stem cells ; Embryos ; Female ; Fundamental and applied biological sciences. Psychology ; Genetics of eukaryotes. Biological and molecular evolution ; Macaca mulatta - embryology ; Mice ; Neonates ; Oocytes ; Pregnancy ; Primates ; Scientific Concepts ; Stem cells ; Twins ; Twins, Monozygotic ; Vertebrata ; Zona Pellucida - physiology</subject><ispartof>Science (American Association for the Advancement of Science), 2000-01, Vol.287 (5451), p.317-319</ispartof><rights>Copyright 2000 American Association for the Advancement of Science</rights><rights>2000 INIST-CNRS</rights><rights>COPYRIGHT 2000 American Association for the Advancement of Science</rights><rights>COPYRIGHT 2000 American Association for the Advancement of Science</rights><rights>Copyright American Association for the Advancement of Science Jan 14, 2000</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c783t-fe4a550f644c8f767ab82a0f27e9823c7c6d230d07bcfa7fc5311dc7e3fd48393</citedby><cites>FETCH-LOGICAL-c783t-fe4a550f644c8f767ab82a0f27e9823c7c6d230d07bcfa7fc5311dc7e3fd48393</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/3074495$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/3074495$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>315,781,785,804,2885,2886,27929,27930,58022,58255</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1278078$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10634789$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chan, A. W. S.</creatorcontrib><creatorcontrib>Dominko, T.</creatorcontrib><creatorcontrib>Luetjens, C. M.</creatorcontrib><creatorcontrib>Neuber, E.</creatorcontrib><creatorcontrib>Martinovich, C.</creatorcontrib><creatorcontrib>Hewitson, L.</creatorcontrib><creatorcontrib>Simerly, C. R.</creatorcontrib><creatorcontrib>Schatten, G. P.</creatorcontrib><title>Clonal Propagation of Primate Offspring by Embryo Splitting</title><title>Science (American Association for the Advancement of Science)</title><addtitle>Science</addtitle><description>Primates that are identical in both nuclear and cytoplasmic components have not been produced by current cloning strategies, yet such identicals represent the ideal model for investigations of human diseases. Here, genetically identical nonhuman embryos were produced as twin and larger sets by separation and reaggregation of blastomeres of cleavage-stage embryos. A total of 368 multiples were created by the splitting of 107 rhesus embryos with four pregnancies established after 13 embryo transfers (31% versus 53% in vitro fertilization controls). The birth of Tetra, a healthy female cloned from a quarter of an embryo, proves that this approach can result in live offspring.</description><subject>Animals</subject><subject>Apoptosis</subject><subject>Biological and medical sciences</subject><subject>Blastocyst</subject><subject>Blastocyst - physiology</subject><subject>Blastomeres</subject><subject>Blastomeres - physiology</subject><subject>Body Weight</subject><subject>Classical genetics, quantitative genetics, hybrids</subject><subject>Cleavage Stage, Ovum - physiology</subject><subject>Cloning</subject><subject>Cloning, Organism - methods</subject><subject>Embryo Transfer</subject><subject>Embryonic and Fetal Development</subject><subject>Embryonic cells</subject><subject>Embryonic stem cells</subject><subject>Embryos</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Genetics of eukaryotes. Biological and molecular evolution</subject><subject>Macaca mulatta - embryology</subject><subject>Mice</subject><subject>Neonates</subject><subject>Oocytes</subject><subject>Pregnancy</subject><subject>Primates</subject><subject>Scientific Concepts</subject><subject>Stem cells</subject><subject>Twins</subject><subject>Twins, Monozygotic</subject><subject>Vertebrata</subject><subject>Zona Pellucida - physiology</subject><issn>0036-8075</issn><issn>1095-9203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqN0--L0zAYB_AiijdP_4NDioj64jrzOym-Osc5D4YTTn0b0jQpHV1TkxTcf29GhzoZOvIi5Hk-yYvkmyy7gmAOIWJvg25Nr80cCT6nhMI5hvxBNoOgpEWJAH6YzQDArBCA04vsSQgbAFKvxI-zCwgYJlyUs-zdonO96vLP3g2qUbF1fe5sWrZbFU2-tjYMvu2bvNrlt9vK71x-P3RtjKn2NHtkVRfMs8N8mX39cPtl8bFYrZd3i5tVobnAsbCGKEqBZYRoYTnjqhJIAYu4KQXCmmtWIwxqwCttFbeaYghrzQ22NRG4xJfZ6-ncwbvvowlRbtugTdep3rgxSE4wxIgRluSrf0sgOGHw_xCmMwUFKMEXf8GNG326sSARxJSzUpCErifUqM7ItrcueqUb0xuv0vUa26byDS2BYEzwxIsTPI3abFt9yr858olE8yM2agxB3t1_Opuuv51N3y_PpWK5OqLXp6h2XWcaI1MuFusjTiauvQvBGyuHffL8TkIg9zGXh5jLFHO5j7lMMU_bnh9eZay2pv5j05TrBF4egApaddarXrfht0M8fQuR2NXENiE6_6uNASekpPgn5BgKHw</recordid><startdate>20000114</startdate><enddate>20000114</enddate><creator>Chan, A. 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| ispartof | Science (American Association for the Advancement of Science), 2000-01, Vol.287 (5451), p.317-319 |
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| source | MEDLINE; Science Magazine; JSTOR Archive Collection A-Z Listing |
| subjects | Animals Apoptosis Biological and medical sciences Blastocyst Blastocyst - physiology Blastomeres Blastomeres - physiology Body Weight Classical genetics, quantitative genetics, hybrids Cleavage Stage, Ovum - physiology Cloning Cloning, Organism - methods Embryo Transfer Embryonic and Fetal Development Embryonic cells Embryonic stem cells Embryos Female Fundamental and applied biological sciences. Psychology Genetics of eukaryotes. Biological and molecular evolution Macaca mulatta - embryology Mice Neonates Oocytes Pregnancy Primates Scientific Concepts Stem cells Twins Twins, Monozygotic Vertebrata Zona Pellucida - physiology |
| title | Clonal Propagation of Primate Offspring by Embryo Splitting |
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