Common Neural Substrates for the Addictive Properties of Nicotine and Cocaine
Regional brain activation was assessed by mapping of Fos-related protein expression in rats trained to self-administration of intravenous nicotine and cocaine. Both drugs produced specific overlapping patterns of activation in the shell and the core of the nucleus accumbens, medial prefrontal cortex...
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| Veröffentlicht in: | Science (American Association for the Advancement of Science) 1997-01, Vol.275 (5296), p.83-86 |
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| container_title | Science (American Association for the Advancement of Science) |
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| creator | Pich, Emilio Merlo Pagliusi, Sonia R. Tessari, Michela Talabot-Ayer, Dominique van Huijsduijnen, Rob Hooft Chiamulera, Christian |
| description | Regional brain activation was assessed by mapping of Fos-related protein expression in rats trained to self-administration of intravenous nicotine and cocaine. Both drugs produced specific overlapping patterns of activation in the shell and the core of the nucleus accumbens, medial prefrontal cortex, and medial caudate areas, but not in the amygdala. Thus, the reinforcing properties of cocaine and nicotine map on selected structures of the terminal fields of the mesocorticolimbic dopamine system, supporting the idea that common substrates for these addictive drugs exist. |
| doi_str_mv | 10.1126/science.275.5296.83 |
| format | Article |
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Both drugs produced specific overlapping patterns of activation in the shell and the core of the nucleus accumbens, medial prefrontal cortex, and medial caudate areas, but not in the amygdala. Thus, the reinforcing properties of cocaine and nicotine map on selected structures of the terminal fields of the mesocorticolimbic dopamine system, supporting the idea that common substrates for these addictive drugs exist.</description><identifier>ISSN: 0036-8075</identifier><identifier>EISSN: 1095-9203</identifier><identifier>DOI: 10.1126/science.275.5296.83</identifier><identifier>PMID: 8974398</identifier><identifier>CODEN: SCIEAS</identifier><language>eng</language><publisher>Washington, DC: American Society for the Advancement of Science</publisher><subject>Addictions ; Amygdala ; Amygdala - drug effects ; Amygdala - metabolism ; Anatomical correlates of behavior ; Animals ; Antibodies ; Behavioral neuroscience ; Behavioral psychophysiology ; Biological and medical sciences ; Brain ; Brain - drug effects ; Brain - metabolism ; Brain Mapping ; Cocaine ; Cocaine - administration & dosage ; Cocaine - pharmacology ; Common property ownership ; DNA - metabolism ; Drug abuse ; Fear of Success ; Fundamental and applied biological sciences. Psychology ; Narcotics ; Neostriatum - drug effects ; Neostriatum - metabolism ; Neurons ; Neurons - drug effects ; Neurons - metabolism ; Nicotine ; Nicotine - administration & dosage ; Nicotine - pharmacology ; Nucleus accumbens ; Nucleus Accumbens - drug effects ; Nucleus Accumbens - metabolism ; Opioid-Related Disorders - etiology ; Physiological aspects ; Prefrontal cortex ; Prefrontal Cortex - drug effects ; Prefrontal Cortex - metabolism ; Proteins ; Proto-Oncogene Proteins c-fos - biosynthesis ; Psychology. Psychoanalysis. Psychiatry ; Psychology. Psychophysiology ; Rats ; Reinforcement (Psychology) ; Rodents ; Self Administration ; Substance-Related Disorders - etiology ; Superior colliculus ; Transcription Factor AP-1 - metabolism</subject><ispartof>Science (American Association for the Advancement of Science), 1997-01, Vol.275 (5296), p.83-86</ispartof><rights>Copyright 1997 American Association for the Advancement of Science</rights><rights>1997 INIST-CNRS</rights><rights>COPYRIGHT 1997 American Association for the Advancement of Science</rights><rights>COPYRIGHT 1997 American Association for the Advancement of Science</rights><rights>Copyright American Association for the Advancement of Science Jan 3, 1997</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c779t-9e78427064a2255d6579cb7f4150d0d72a4bc52fceb15f1218f78448dcade2b53</citedby><cites>FETCH-LOGICAL-c779t-9e78427064a2255d6579cb7f4150d0d72a4bc52fceb15f1218f78448dcade2b53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/2892122$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/2892122$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,776,780,799,2871,2872,27901,27902,57992,58225</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2538696$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8974398$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pich, Emilio Merlo</creatorcontrib><creatorcontrib>Pagliusi, Sonia R.</creatorcontrib><creatorcontrib>Tessari, Michela</creatorcontrib><creatorcontrib>Talabot-Ayer, Dominique</creatorcontrib><creatorcontrib>van Huijsduijnen, Rob Hooft</creatorcontrib><creatorcontrib>Chiamulera, Christian</creatorcontrib><title>Common Neural Substrates for the Addictive Properties of Nicotine and Cocaine</title><title>Science (American Association for the Advancement of Science)</title><addtitle>Science</addtitle><description>Regional brain activation was assessed by mapping of Fos-related protein expression in rats trained to self-administration of intravenous nicotine and cocaine. Both drugs produced specific overlapping patterns of activation in the shell and the core of the nucleus accumbens, medial prefrontal cortex, and medial caudate areas, but not in the amygdala. Thus, the reinforcing properties of cocaine and nicotine map on selected structures of the terminal fields of the mesocorticolimbic dopamine system, supporting the idea that common substrates for these addictive drugs exist.</description><subject>Addictions</subject><subject>Amygdala</subject><subject>Amygdala - drug effects</subject><subject>Amygdala - metabolism</subject><subject>Anatomical correlates of behavior</subject><subject>Animals</subject><subject>Antibodies</subject><subject>Behavioral neuroscience</subject><subject>Behavioral psychophysiology</subject><subject>Biological and medical sciences</subject><subject>Brain</subject><subject>Brain - drug effects</subject><subject>Brain - metabolism</subject><subject>Brain Mapping</subject><subject>Cocaine</subject><subject>Cocaine - administration & dosage</subject><subject>Cocaine - pharmacology</subject><subject>Common property ownership</subject><subject>DNA - metabolism</subject><subject>Drug abuse</subject><subject>Fear of Success</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Narcotics</subject><subject>Neostriatum - drug effects</subject><subject>Neostriatum - metabolism</subject><subject>Neurons</subject><subject>Neurons - drug effects</subject><subject>Neurons - metabolism</subject><subject>Nicotine</subject><subject>Nicotine - administration & dosage</subject><subject>Nicotine - pharmacology</subject><subject>Nucleus accumbens</subject><subject>Nucleus Accumbens - drug effects</subject><subject>Nucleus Accumbens - metabolism</subject><subject>Opioid-Related Disorders - etiology</subject><subject>Physiological aspects</subject><subject>Prefrontal cortex</subject><subject>Prefrontal Cortex - drug effects</subject><subject>Prefrontal Cortex - metabolism</subject><subject>Proteins</subject><subject>Proto-Oncogene Proteins c-fos - biosynthesis</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychology. 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Both drugs produced specific overlapping patterns of activation in the shell and the core of the nucleus accumbens, medial prefrontal cortex, and medial caudate areas, but not in the amygdala. Thus, the reinforcing properties of cocaine and nicotine map on selected structures of the terminal fields of the mesocorticolimbic dopamine system, supporting the idea that common substrates for these addictive drugs exist.</abstract><cop>Washington, DC</cop><pub>American Society for the Advancement of Science</pub><pmid>8974398</pmid><doi>10.1126/science.275.5296.83</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0036-8075 |
| ispartof | Science (American Association for the Advancement of Science), 1997-01, Vol.275 (5296), p.83-86 |
| issn | 0036-8075 1095-9203 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_743129253 |
| source | American Association for the Advancement of Science; Jstor Complete Legacy; MEDLINE |
| subjects | Addictions Amygdala Amygdala - drug effects Amygdala - metabolism Anatomical correlates of behavior Animals Antibodies Behavioral neuroscience Behavioral psychophysiology Biological and medical sciences Brain Brain - drug effects Brain - metabolism Brain Mapping Cocaine Cocaine - administration & dosage Cocaine - pharmacology Common property ownership DNA - metabolism Drug abuse Fear of Success Fundamental and applied biological sciences. Psychology Narcotics Neostriatum - drug effects Neostriatum - metabolism Neurons Neurons - drug effects Neurons - metabolism Nicotine Nicotine - administration & dosage Nicotine - pharmacology Nucleus accumbens Nucleus Accumbens - drug effects Nucleus Accumbens - metabolism Opioid-Related Disorders - etiology Physiological aspects Prefrontal cortex Prefrontal Cortex - drug effects Prefrontal Cortex - metabolism Proteins Proto-Oncogene Proteins c-fos - biosynthesis Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Rats Reinforcement (Psychology) Rodents Self Administration Substance-Related Disorders - etiology Superior colliculus Transcription Factor AP-1 - metabolism |
| title | Common Neural Substrates for the Addictive Properties of Nicotine and Cocaine |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-02T01%3A57%3A23IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Common%20Neural%20Substrates%20for%20the%20Addictive%20Properties%20of%20Nicotine%20and%20Cocaine&rft.jtitle=Science%20(American%20Association%20for%20the%20Advancement%20of%20Science)&rft.au=Pich,%20Emilio%20Merlo&rft.date=1997-01-03&rft.volume=275&rft.issue=5296&rft.spage=83&rft.epage=86&rft.pages=83-86&rft.issn=0036-8075&rft.eissn=1095-9203&rft.coden=SCIEAS&rft_id=info:doi/10.1126/science.275.5296.83&rft_dat=%3Cgale_proqu%3EA19031319%3C/gale_proqu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=213575176&rft_id=info:pmid/8974398&rft_galeid=A19031319&rft_jstor_id=2892122&rfr_iscdi=true |