CD4+ T cells are required for secondary expansion and memory in CD8+ T lymphocytes

A long-standing paradox in cellular immunology concerns the conditional requirement for CD4 + T-helper (T H ) cells in the priming of cytotoxic CD8 + T lymphocyte (CTL) responses in vivo . Whereas CTL responses against certain viruses can be primed in the absence of CD4 + T cells, others, such as th...

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