CD2-Associated Protein Haploinsufficiency Is Linked to Glomerular Disease Susceptibility

Loss of CD2-associated protein (CD2AP), a component of the filtration complex in the kidney, causes death in mice at 6 weeks of age. Mice with CD2AP haploinsufficiency developed glomerular changes at 9 months of age and had increased susceptibility to glomerular injury by nephrotoxic antibodies or i...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Science (American Association for the Advancement of Science) 2003-05, Vol.300 (5623), p.1298-1300
Hauptverfasser:	Kim, Jeong M., Wu, Hui, Green, Gopa, Winkler, Cheryl A., Kopp, Jeffrey B., Miner, Jeffrey H., Unanue, Emil R., Shaw, Andrey S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing African Americans Animals Antigen-Antibody Complex B lymphocytes Basement Membrane - immunology Basement Membrane - metabolism Basement Membrane - pathology Biological and medical sciences Chromatography, High Pressure Liquid Control Groups Cytoskeletal Proteins Disease Endocytosis Epithelial Cells - pathology Epithelial Cells - physiology Etiology Exhibits Exons Ferritins Ferritins - metabolism Focal segmental glomerulosclerosis Genetic aspects Genetic Predisposition to Disease Genetic Variation Glomerular Mesangium - immunology Glomerular Mesangium - pathology Glomerulonephritis Glomerulosclerosis, Focal Segmental - genetics Glomerulosclerosis, Focal Segmental - metabolism Glomerulosclerosis, Focal Segmental - pathology Heterozygote Humans Immunoglobulins - analysis Kidney cortex Kidney diseases Kidney Diseases - genetics Kidney Diseases - metabolism Kidney Diseases - pathology Kidney Glomerulus - immunology Kidney Glomerulus - metabolism Kidney Glomerulus - pathology Kidneys Medical sciences Mice Mice, Knockout Mutation Nephrology. Urinary tract diseases Nephropathies. Renovascular diseases. Renal failure Pathology Patients Polymerase Chain Reaction Polymorphism, Genetic Proteins Proteins - genetics Proteins - physiology Proteinuria Proteinuria - etiology RNA Splicing
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!