Accumulation of Phosphorylated Repressor for Gibberellin Signaling in an F-Box Mutant
Gibberellin (GA) regulates growth and development in plants. We isolated and characterized a rice GA-insensitive dwarf mutant, gid2. The CID2 gene encodes a putative F-box protein, which interacted with the rice Skp1 homolog in a yeast two-hybrid assay. In gid2, a repressor for GA signaling, SLR1, w...
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| Veröffentlicht in: | Science (American Association for the Advancement of Science) 2003-03, Vol.299 (5614), p.1896-1898 |
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| container_end_page | 1898 |
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| container_issue | 5614 |
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| container_title | Science (American Association for the Advancement of Science) |
| container_volume | 299 |
| creator | Sasaki, Akie Itoh, Hironori Gomi, Kenji Ueguchi-Tanaka, Miyako Ishiyama, Kanako Kobayashi, Masatomo Jeong, Dong-Hoon An, Gynheung Kitano, Hidemi Ashikari, Motoyuki Matsuoka, Makoto |
| description | Gibberellin (GA) regulates growth and development in plants. We isolated and characterized a rice GA-insensitive dwarf mutant, gid2. The CID2 gene encodes a putative F-box protein, which interacted with the rice Skp1 homolog in a yeast two-hybrid assay. In gid2, a repressor for GA signaling, SLR1, was highly accumulated in a phosphorylated form and GA increased its concentration, whereas SLR1 was rapidly degraded by GA through ubiquitination in the wild type. We conclude that GID2 is a positive regulator of GA signaling and that regulated degradation of SLR1 is initiated through GA-dependent phosphorylation and finalized by an$SCF^{GID2}-proteasome$pathway. |
| doi_str_mv | 10.1126/science.1081077 |
| format | Article |
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We isolated and characterized a rice GA-insensitive dwarf mutant, gid2. The CID2 gene encodes a putative F-box protein, which interacted with the rice Skp1 homolog in a yeast two-hybrid assay. In gid2, a repressor for GA signaling, SLR1, was highly accumulated in a phosphorylated form and GA increased its concentration, whereas SLR1 was rapidly degraded by GA through ubiquitination in the wild type. We conclude that GID2 is a positive regulator of GA signaling and that regulated degradation of SLR1 is initiated through GA-dependent phosphorylation and finalized by an$SCF^{GID2}-proteasome$pathway.</description><identifier>ISSN: 0036-8075</identifier><identifier>EISSN: 1095-9203</identifier><identifier>DOI: 10.1126/science.1081077</identifier><identifier>PMID: 12649483</identifier><identifier>CODEN: SCIEAS</identifier><language>eng</language><publisher>Washington, DC: American Association for the Advancement of Science</publisher><subject>Alleles ; alpha-Amylases - biosynthesis ; Amino Acid Sequence ; Antibodies ; Biological and medical sciences ; Codon, Terminator ; Company growth ; DELLA protein ; Enzyme Induction ; F box proteins ; Freshwater ; Fundamental and applied biological sciences. Psychology ; Genes, Plant ; Genetic aspects ; Genetics ; Gibberellins - metabolism ; Gibberellins - pharmacology ; GID2 gene ; Growth ; Immunoblotting ; Ligases - metabolism ; Literary Devices ; Logical Thinking ; Molecular Sequence Data ; Mutation ; Open Reading Frames ; Oryza - genetics ; Oryza - growth & development ; Oryza - metabolism ; Oryza sativa ; Peptide Hydrolases - metabolism ; Phenotype ; Phenotypes ; Phosphorylation ; Plant cells ; Plant growth ; Plant growth regulators ; Plant growth. Development of the storage organs ; Plant hormones ; Plant physiology and development ; Plant proteins ; Plant Proteins - chemistry ; Plant Proteins - genetics ; Plant Proteins - metabolism ; Plants ; Plants (Organisms) ; Proteasome Endopeptidase Complex ; proteasomes ; Protein Structure, Tertiary ; Rice ; Seeds - metabolism ; Signal Transduction ; SLR1 gene ; Ubiquitin - metabolism ; Ubiquitin-Protein Ligases ; Vegetative apparatus, growth and morphogenesis. Senescence ; Yeasts</subject><ispartof>Science (American Association for the Advancement of Science), 2003-03, Vol.299 (5614), p.1896-1898</ispartof><rights>Copyright 2003 American Association for the Advancement of Science</rights><rights>2003 INIST-CNRS</rights><rights>COPYRIGHT 2003 American Association for the Advancement of Science</rights><rights>COPYRIGHT 2003 American Association for the Advancement of Science</rights><rights>Copyright American Association for the Advancement of Science Mar 21, 2003</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c775t-7e4d420cfdf44a273e0f58454dd004d28d29aa2a3a87f96eff2decbf38d567f33</citedby><cites>FETCH-LOGICAL-c775t-7e4d420cfdf44a273e0f58454dd004d28d29aa2a3a87f96eff2decbf38d567f33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/3833874$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/3833874$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,776,780,799,2871,2872,27901,27902,57992,58225</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14648160$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12649483$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sasaki, Akie</creatorcontrib><creatorcontrib>Itoh, Hironori</creatorcontrib><creatorcontrib>Gomi, Kenji</creatorcontrib><creatorcontrib>Ueguchi-Tanaka, Miyako</creatorcontrib><creatorcontrib>Ishiyama, Kanako</creatorcontrib><creatorcontrib>Kobayashi, Masatomo</creatorcontrib><creatorcontrib>Jeong, Dong-Hoon</creatorcontrib><creatorcontrib>An, Gynheung</creatorcontrib><creatorcontrib>Kitano, Hidemi</creatorcontrib><creatorcontrib>Ashikari, Motoyuki</creatorcontrib><creatorcontrib>Matsuoka, Makoto</creatorcontrib><title>Accumulation of Phosphorylated Repressor for Gibberellin Signaling in an F-Box Mutant</title><title>Science (American Association for the Advancement of Science)</title><addtitle>Science</addtitle><description>Gibberellin (GA) regulates growth and development in plants. We isolated and characterized a rice GA-insensitive dwarf mutant, gid2. The CID2 gene encodes a putative F-box protein, which interacted with the rice Skp1 homolog in a yeast two-hybrid assay. In gid2, a repressor for GA signaling, SLR1, was highly accumulated in a phosphorylated form and GA increased its concentration, whereas SLR1 was rapidly degraded by GA through ubiquitination in the wild type. We conclude that GID2 is a positive regulator of GA signaling and that regulated degradation of SLR1 is initiated through GA-dependent phosphorylation and finalized by an$SCF^{GID2}-proteasome$pathway.</description><subject>Alleles</subject><subject>alpha-Amylases - biosynthesis</subject><subject>Amino Acid Sequence</subject><subject>Antibodies</subject><subject>Biological and medical sciences</subject><subject>Codon, Terminator</subject><subject>Company growth</subject><subject>DELLA protein</subject><subject>Enzyme Induction</subject><subject>F box proteins</subject><subject>Freshwater</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Genes, Plant</subject><subject>Genetic aspects</subject><subject>Genetics</subject><subject>Gibberellins - metabolism</subject><subject>Gibberellins - pharmacology</subject><subject>GID2 gene</subject><subject>Growth</subject><subject>Immunoblotting</subject><subject>Ligases - metabolism</subject><subject>Literary Devices</subject><subject>Logical Thinking</subject><subject>Molecular Sequence Data</subject><subject>Mutation</subject><subject>Open Reading Frames</subject><subject>Oryza - genetics</subject><subject>Oryza - growth & development</subject><subject>Oryza - metabolism</subject><subject>Oryza sativa</subject><subject>Peptide Hydrolases - metabolism</subject><subject>Phenotype</subject><subject>Phenotypes</subject><subject>Phosphorylation</subject><subject>Plant cells</subject><subject>Plant growth</subject><subject>Plant growth regulators</subject><subject>Plant growth. Development of the storage organs</subject><subject>Plant hormones</subject><subject>Plant physiology and development</subject><subject>Plant proteins</subject><subject>Plant Proteins - chemistry</subject><subject>Plant Proteins - genetics</subject><subject>Plant Proteins - metabolism</subject><subject>Plants</subject><subject>Plants (Organisms)</subject><subject>Proteasome Endopeptidase Complex</subject><subject>proteasomes</subject><subject>Protein Structure, Tertiary</subject><subject>Rice</subject><subject>Seeds - metabolism</subject><subject>Signal Transduction</subject><subject>SLR1 gene</subject><subject>Ubiquitin - metabolism</subject><subject>Ubiquitin-Protein Ligases</subject><subject>Vegetative apparatus, growth and morphogenesis. 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Psychology</topic><topic>Genes, Plant</topic><topic>Genetic aspects</topic><topic>Genetics</topic><topic>Gibberellins - metabolism</topic><topic>Gibberellins - pharmacology</topic><topic>GID2 gene</topic><topic>Growth</topic><topic>Immunoblotting</topic><topic>Ligases - metabolism</topic><topic>Literary Devices</topic><topic>Logical Thinking</topic><topic>Molecular Sequence Data</topic><topic>Mutation</topic><topic>Open Reading Frames</topic><topic>Oryza - genetics</topic><topic>Oryza - growth & development</topic><topic>Oryza - metabolism</topic><topic>Oryza sativa</topic><topic>Peptide Hydrolases - metabolism</topic><topic>Phenotype</topic><topic>Phenotypes</topic><topic>Phosphorylation</topic><topic>Plant cells</topic><topic>Plant growth</topic><topic>Plant growth regulators</topic><topic>Plant growth. Development of the storage organs</topic><topic>Plant hormones</topic><topic>Plant physiology and development</topic><topic>Plant proteins</topic><topic>Plant Proteins - chemistry</topic><topic>Plant Proteins - genetics</topic><topic>Plant Proteins - metabolism</topic><topic>Plants</topic><topic>Plants (Organisms)</topic><topic>Proteasome Endopeptidase Complex</topic><topic>proteasomes</topic><topic>Protein Structure, Tertiary</topic><topic>Rice</topic><topic>Seeds - metabolism</topic><topic>Signal Transduction</topic><topic>SLR1 gene</topic><topic>Ubiquitin - metabolism</topic><topic>Ubiquitin-Protein Ligases</topic><topic>Vegetative apparatus, growth and morphogenesis. 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Makoto</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Accumulation of Phosphorylated Repressor for Gibberellin Signaling in an F-Box Mutant</atitle><jtitle>Science (American Association for the Advancement of Science)</jtitle><addtitle>Science</addtitle><date>2003-03-21</date><risdate>2003</risdate><volume>299</volume><issue>5614</issue><spage>1896</spage><epage>1898</epage><pages>1896-1898</pages><issn>0036-8075</issn><eissn>1095-9203</eissn><coden>SCIEAS</coden><abstract>Gibberellin (GA) regulates growth and development in plants. We isolated and characterized a rice GA-insensitive dwarf mutant, gid2. The CID2 gene encodes a putative F-box protein, which interacted with the rice Skp1 homolog in a yeast two-hybrid assay. In gid2, a repressor for GA signaling, SLR1, was highly accumulated in a phosphorylated form and GA increased its concentration, whereas SLR1 was rapidly degraded by GA through ubiquitination in the wild type. We conclude that GID2 is a positive regulator of GA signaling and that regulated degradation of SLR1 is initiated through GA-dependent phosphorylation and finalized by an$SCF^{GID2}-proteasome$pathway.</abstract><cop>Washington, DC</cop><pub>American Association for the Advancement of Science</pub><pmid>12649483</pmid><doi>10.1126/science.1081077</doi><tpages>3</tpages></addata></record> |
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| identifier | ISSN: 0036-8075 |
| ispartof | Science (American Association for the Advancement of Science), 2003-03, Vol.299 (5614), p.1896-1898 |
| issn | 0036-8075 1095-9203 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_743113367 |
| source | American Association for the Advancement of Science; Jstor Complete Legacy; MEDLINE |
| subjects | Alleles alpha-Amylases - biosynthesis Amino Acid Sequence Antibodies Biological and medical sciences Codon, Terminator Company growth DELLA protein Enzyme Induction F box proteins Freshwater Fundamental and applied biological sciences. Psychology Genes, Plant Genetic aspects Genetics Gibberellins - metabolism Gibberellins - pharmacology GID2 gene Growth Immunoblotting Ligases - metabolism Literary Devices Logical Thinking Molecular Sequence Data Mutation Open Reading Frames Oryza - genetics Oryza - growth & development Oryza - metabolism Oryza sativa Peptide Hydrolases - metabolism Phenotype Phenotypes Phosphorylation Plant cells Plant growth Plant growth regulators Plant growth. Development of the storage organs Plant hormones Plant physiology and development Plant proteins Plant Proteins - chemistry Plant Proteins - genetics Plant Proteins - metabolism Plants Plants (Organisms) Proteasome Endopeptidase Complex proteasomes Protein Structure, Tertiary Rice Seeds - metabolism Signal Transduction SLR1 gene Ubiquitin - metabolism Ubiquitin-Protein Ligases Vegetative apparatus, growth and morphogenesis. Senescence Yeasts |
| title | Accumulation of Phosphorylated Repressor for Gibberellin Signaling in an F-Box Mutant |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-30T19%3A37%3A49IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Accumulation%20of%20Phosphorylated%20Repressor%20for%20Gibberellin%20Signaling%20in%20an%20F-Box%20Mutant&rft.jtitle=Science%20(American%20Association%20for%20the%20Advancement%20of%20Science)&rft.au=Sasaki,%20Akie&rft.date=2003-03-21&rft.volume=299&rft.issue=5614&rft.spage=1896&rft.epage=1898&rft.pages=1896-1898&rft.issn=0036-8075&rft.eissn=1095-9203&rft.coden=SCIEAS&rft_id=info:doi/10.1126/science.1081077&rft_dat=%3Cgale_proqu%3EA99849733%3C/gale_proqu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=213591267&rft_id=info:pmid/12649483&rft_galeid=A99849733&rft_jstor_id=3833874&rfr_iscdi=true |