Absence of Junctional Glutamate Receptor Clusters in Drosophila Mutants Lacking Spontaneous Transmitter Release
Little is known about the functional significance of spontaneous miniature synaptic potentials, which are the result of vesicular exocytosis at nerve terminals. Here, by using Drosophila mutants with specific defects in presynaptic function, we found that glutamate receptors clustered normally at ne...
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| Veröffentlicht in: | Science (American Association for the Advancement of Science) 2001-07, Vol.293 (5529), p.514-517 |
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| creator | Saitoe, Minoru Schwarz, Thomas L. Umbach, Joy A. Gundersen, Cameron B. Kidokoro, Yoshiaki |
| description | Little is known about the functional significance of spontaneous miniature synaptic potentials, which are the result of vesicular exocytosis at nerve terminals. Here, by using Drosophila mutants with specific defects in presynaptic function, we found that glutamate receptors clustered normally at neuromuscular junctions of mutants that retained spontaneous transmitter secretion but had lost the ability to release transmitter in response to action potentials. In contrast, receptor clustering was defective in mutants in which both spontaneous and evoked vesicle exocytosis were absent. Thus, spontaneous vesicle exocytosis appears to be tightly linked to the clustering of glutamate receptors during development. |
| doi_str_mv | 10.1126/science.1061270 |
| format | Article |
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Thus, spontaneous vesicle exocytosis appears to be tightly linked to the clustering of glutamate receptors during development.</description><identifier>ISSN: 0036-8075</identifier><identifier>EISSN: 1095-9203</identifier><identifier>DOI: 10.1126/science.1061270</identifier><identifier>PMID: 11463917</identifier><identifier>CODEN: SCIEAS</identifier><language>eng</language><publisher>Washington, DC: American Society for the Advancement of Science</publisher><subject>Action Potentials ; Anatomy ; Animals ; Antibodies ; Behavioral neuroscience ; Biological and medical sciences ; Cell physiology ; Drosophila ; Drosophila - embryology ; Drosophila - genetics ; Drosophila - physiology ; Embryos ; Exocytosis ; Fundamental and applied biological sciences. Psychology ; Glutamate ; Glutamic Acid - pharmacology ; Insects ; Larvae ; Membrane Proteins - genetics ; Membrane Proteins - metabolism ; Membranes ; Molecular and cellular biology ; Mutation ; Nervous system ; Neural receptors ; Neuromuscular Junction - embryology ; Neuromuscular Junction - metabolism ; Neuromuscular Junction - physiology ; Neurons ; Neuroscience ; Neurotransmission ; Presynaptic Terminals - metabolism ; Presynaptic Terminals - physiology ; Qa-SNARE Proteins ; R-SNARE Proteins ; Receptor Aggregation ; Receptors ; Receptors, Glutamate - metabolism ; Spider Venoms - pharmacology ; Synaptic Membranes - metabolism ; Synaptic Membranes - physiology ; Synaptic Transmission ; Synaptic Vesicles - metabolism ; Synaptic Vesicles - physiology ; Temperature ; Tetrodotoxin - pharmacology ; Transgenes</subject><ispartof>Science (American Association for the Advancement of Science), 2001-07, Vol.293 (5529), p.514-517</ispartof><rights>Copyright 2001 American Association for the Advancement of Science</rights><rights>2002 INIST-CNRS</rights><rights>COPYRIGHT 2001 American Association for the Advancement of Science</rights><rights>COPYRIGHT 2001 American Association for the Advancement of Science</rights><rights>Copyright American Association for the Advancement of Science Jul 20, 2001</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c708t-fa9a76fd0bda198b14d2dcce64eedd9a62872bf8dd6185311f16f9debb29ee323</citedby><cites>FETCH-LOGICAL-c708t-fa9a76fd0bda198b14d2dcce64eedd9a62872bf8dd6185311f16f9debb29ee323</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/3084100$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/3084100$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,780,784,803,2882,2883,27922,27923,58015,58248</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14121874$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11463917$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Saitoe, Minoru</creatorcontrib><creatorcontrib>Schwarz, Thomas L.</creatorcontrib><creatorcontrib>Umbach, Joy A.</creatorcontrib><creatorcontrib>Gundersen, Cameron B.</creatorcontrib><creatorcontrib>Kidokoro, Yoshiaki</creatorcontrib><title>Absence of Junctional Glutamate Receptor Clusters in Drosophila Mutants Lacking Spontaneous Transmitter Release</title><title>Science (American Association for the Advancement of Science)</title><addtitle>Science</addtitle><description>Little is known about the functional significance of spontaneous miniature synaptic potentials, which are the result of vesicular exocytosis at nerve terminals. 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Thus, spontaneous vesicle exocytosis appears to be tightly linked to the clustering of glutamate receptors during development.</description><subject>Action Potentials</subject><subject>Anatomy</subject><subject>Animals</subject><subject>Antibodies</subject><subject>Behavioral neuroscience</subject><subject>Biological and medical sciences</subject><subject>Cell physiology</subject><subject>Drosophila</subject><subject>Drosophila - embryology</subject><subject>Drosophila - genetics</subject><subject>Drosophila - physiology</subject><subject>Embryos</subject><subject>Exocytosis</subject><subject>Fundamental and applied biological sciences. 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metabolism</subject><subject>Synaptic Membranes - physiology</subject><subject>Synaptic Transmission</subject><subject>Synaptic Vesicles - metabolism</subject><subject>Synaptic Vesicles - physiology</subject><subject>Temperature</subject><subject>Tetrodotoxin - pharmacology</subject><subject>Transgenes</subject><issn>0036-8075</issn><issn>1095-9203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqN08-LEzEUB_BBFLdWz15EBsEfh53dvPmVybFWrSvVgrt6DZnMm5puZlKTDOh_b0oHl0qRksNA8nmPIe-bKHoK5AIgLS-dVNhLvABSQkrJvWgChBUJS0l2P5oQkpVJRWhxFj1ybkNIOGPZw-gMIC8zBnQSmVntdh1i08afhl56ZXqh44UevOiEx_grStx6Y-O5HpxH62LVx--scWb7Q2kRfw6w9y5eCnmr-nV8vTV92EEzuPjGit51yoey0EejcPg4etAK7fDJ-J1G3z68v5l_TJarxdV8tkwkJZVPWsEELduG1I0AVtWQN2kjJZY5YtMwUaYVTeu2apoSqiIDaKFsWYN1nTLELM2m0et93601Pwd0nnfKSdR6_2uc5qEI8nAd0-jVfyVQRnJIiwBf_AM3ZrDhthxPIStoBmUe0PkerYVGrvrWeCvkGnu0QpseWxW2Z7RkjBYFBJ4c4WE12Cl5zL858IF4_OXXYnCOX11_OZmuvp9M3y5OpdVieUDPj1FptMY18jDu-eqAX-65DOFyFlu-taoT9jcHwndh52PY-Rj2UPF8HMhQd9jc-THdAbwcgXBS6DbEUSp358JYoaK7oT3bu40LSf97npEqh_CG_gDckA9B</recordid><startdate>20010720</startdate><enddate>20010720</enddate><creator>Saitoe, Minoru</creator><creator>Schwarz, Thomas L.</creator><creator>Umbach, Joy A.</creator><creator>Gundersen, Cameron B.</creator><creator>Kidokoro, Yoshiaki</creator><general>American Society for the Advancement of Science</general><general>American Association for the Advancement of Science</general><general>The American Association for the Advancement of Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8GL</scope><scope>IBG</scope><scope>IOV</scope><scope>ISN</scope><scope>0-V</scope><scope>3V.</scope><scope>7QF</scope><scope>7QG</scope><scope>7QL</scope><scope>7QP</scope><scope>7QQ</scope><scope>7QR</scope><scope>7SC</scope><scope>7SE</scope><scope>7SN</scope><scope>7SP</scope><scope>7SR</scope><scope>7SS</scope><scope>7T7</scope><scope>7TA</scope><scope>7TB</scope><scope>7TK</scope><scope>7TM</scope><scope>7U5</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88B</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8BQ</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ALSLI</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BEC</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>BKSAR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>CJNVE</scope><scope>D1I</scope><scope>DWQXO</scope><scope>F28</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H8D</scope><scope>H8G</scope><scope>H94</scope><scope>HCIFZ</scope><scope>JG9</scope><scope>JQ2</scope><scope>K9-</scope><scope>K9.</scope><scope>KB.</scope><scope>KR7</scope><scope>L6V</scope><scope>L7M</scope><scope>LK8</scope><scope>L~C</scope><scope>L~D</scope><scope>M0K</scope><scope>M0P</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M2P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>MBDVC</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PCBAR</scope><scope>PDBOC</scope><scope>PQEDU</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>Q9U</scope><scope>R05</scope><scope>RC3</scope></search><sort><creationdate>20010720</creationdate><title>Absence of Junctional Glutamate Receptor Clusters in Drosophila Mutants Lacking Spontaneous Transmitter Release</title><author>Saitoe, Minoru ; Schwarz, Thomas L. ; Umbach, Joy A. ; Gundersen, Cameron B. ; Kidokoro, Yoshiaki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c708t-fa9a76fd0bda198b14d2dcce64eedd9a62872bf8dd6185311f16f9debb29ee323</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Action Potentials</topic><topic>Anatomy</topic><topic>Animals</topic><topic>Antibodies</topic><topic>Behavioral neuroscience</topic><topic>Biological and medical sciences</topic><topic>Cell physiology</topic><topic>Drosophila</topic><topic>Drosophila - embryology</topic><topic>Drosophila - genetics</topic><topic>Drosophila - physiology</topic><topic>Embryos</topic><topic>Exocytosis</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Glutamate</topic><topic>Glutamic Acid - pharmacology</topic><topic>Insects</topic><topic>Larvae</topic><topic>Membrane Proteins - genetics</topic><topic>Membrane Proteins - metabolism</topic><topic>Membranes</topic><topic>Molecular and cellular biology</topic><topic>Mutation</topic><topic>Nervous system</topic><topic>Neural receptors</topic><topic>Neuromuscular Junction - embryology</topic><topic>Neuromuscular Junction - metabolism</topic><topic>Neuromuscular Junction - physiology</topic><topic>Neurons</topic><topic>Neuroscience</topic><topic>Neurotransmission</topic><topic>Presynaptic Terminals - metabolism</topic><topic>Presynaptic Terminals - physiology</topic><topic>Qa-SNARE Proteins</topic><topic>R-SNARE Proteins</topic><topic>Receptor Aggregation</topic><topic>Receptors</topic><topic>Receptors, Glutamate - metabolism</topic><topic>Spider Venoms - pharmacology</topic><topic>Synaptic Membranes - metabolism</topic><topic>Synaptic Membranes - 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| identifier | ISSN: 0036-8075 |
| ispartof | Science (American Association for the Advancement of Science), 2001-07, Vol.293 (5529), p.514-517 |
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| language | eng |
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| source | MEDLINE; JSTOR Archive Collection A-Z Listing; American Association for the Advancement of Science |
| subjects | Action Potentials Anatomy Animals Antibodies Behavioral neuroscience Biological and medical sciences Cell physiology Drosophila Drosophila - embryology Drosophila - genetics Drosophila - physiology Embryos Exocytosis Fundamental and applied biological sciences. Psychology Glutamate Glutamic Acid - pharmacology Insects Larvae Membrane Proteins - genetics Membrane Proteins - metabolism Membranes Molecular and cellular biology Mutation Nervous system Neural receptors Neuromuscular Junction - embryology Neuromuscular Junction - metabolism Neuromuscular Junction - physiology Neurons Neuroscience Neurotransmission Presynaptic Terminals - metabolism Presynaptic Terminals - physiology Qa-SNARE Proteins R-SNARE Proteins Receptor Aggregation Receptors Receptors, Glutamate - metabolism Spider Venoms - pharmacology Synaptic Membranes - metabolism Synaptic Membranes - physiology Synaptic Transmission Synaptic Vesicles - metabolism Synaptic Vesicles - physiology Temperature Tetrodotoxin - pharmacology Transgenes |
| title | Absence of Junctional Glutamate Receptor Clusters in Drosophila Mutants Lacking Spontaneous Transmitter Release |
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