Biosynthesis of the Food and Cosmetic Plant Pigment Bixin (Annatto)
Bixin, also known as annatto, is a seed-specific pigment widely used in foods and cosmetics since pre-Columbian times. We show that three genes from Bixa orellana, native to tropical America, govern bixin biosynthesis. These genes code for lycopene cleavage dioxygenase, bixin aldehyde dehydrogenase,...
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| Veröffentlicht in: | Science (American Association for the Advancement of Science) 2003-06, Vol.300 (5628), p.2089-2091 |
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| creator | Bouvier, Florence Dogbo, Odette Camara, Bilal |
| description | Bixin, also known as annatto, is a seed-specific pigment widely used in foods and cosmetics since pre-Columbian times. We show that three genes from Bixa orellana, native to tropical America, govern bixin biosynthesis. These genes code for lycopene cleavage dioxygenase, bixin aldehyde dehydrogenase, and norbixin carboxyl methyltransferase, which catalyze the sequential conversion of lycopene into bixin. Introduction of these three genes in Escherichia coli engineered to produce lycopene induced bixin synthesis, thus expanding the supply of this economically important plant product. |
| doi_str_mv | 10.1126/science.1085162 |
| format | Article |
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We show that three genes from Bixa orellana, native to tropical America, govern bixin biosynthesis. These genes code for lycopene cleavage dioxygenase, bixin aldehyde dehydrogenase, and norbixin carboxyl methyltransferase, which catalyze the sequential conversion of lycopene into bixin. Introduction of these three genes in Escherichia coli engineered to produce lycopene induced bixin synthesis, thus expanding the supply of this economically important plant product.</description><identifier>ISSN: 0036-8075</identifier><identifier>EISSN: 1095-9203</identifier><identifier>DOI: 10.1126/science.1085162</identifier><identifier>PMID: 12829782</identifier><identifier>CODEN: SCIEAS</identifier><language>eng</language><publisher>Washington, DC: American Association for the Advancement of Science</publisher><subject>Aldehyde Dehydrogenase - chemistry ; Aldehyde Dehydrogenase - genetics ; Aldehyde Dehydrogenase - metabolism ; Aldehydes ; Amino Acid Sequence ; Amino acids ; Annatto ; Biological and medical sciences ; Biosynthesis ; Biotechnology ; Bixaceae - genetics ; Bixaceae - metabolism ; Carotenoids ; Carotenoids - biosynthesis ; Carotenoids - metabolism ; Catalysis ; Cloning, Molecular ; Coding ; Complementary DNA ; Dehydrogenases ; DNA, Complementary ; Enzymes ; Escherichia coli - genetics ; Escherichia coli - metabolism ; Flowers & plants ; Fundamental and applied biological sciences. Psychology ; Gene Library ; Genes ; Genes, Plant ; Genetic aspects ; Genetic engineering ; Genetic technics ; Methods. Procedures. Technologies ; Methyltransferases - chemistry ; Methyltransferases - genetics ; Methyltransferases - metabolism ; Modification of gene expression level ; Molecular Sequence Data ; Oxygenases - genetics ; Oxygenases - metabolism ; Pigments ; Plant pigments ; Recombinant Proteins - metabolism ; Scientific Concepts ; Seeds - genetics ; Sodium channels ; Transformation, Bacterial</subject><ispartof>Science (American Association for the Advancement of Science), 2003-06, Vol.300 (5628), p.2089-2091</ispartof><rights>Copyright 2003 American Association for the Advancement of Science</rights><rights>2003 INIST-CNRS</rights><rights>COPYRIGHT 2003 American Association for the Advancement of Science</rights><rights>COPYRIGHT 2003 American Association for the Advancement of Science</rights><rights>Copyright American Association for the Advancement of Science Jun 27, 2003</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c819t-5ddca6cc3394fbad6e7acb9bbe11d887fb07acff4b774eb24b6bbd920f8d8aca3</citedby><cites>FETCH-LOGICAL-c819t-5ddca6cc3394fbad6e7acb9bbe11d887fb07acff4b774eb24b6bbd920f8d8aca3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/3834418$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/3834418$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,776,780,799,2870,2871,27903,27904,57995,58228</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14946804$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12829782$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bouvier, Florence</creatorcontrib><creatorcontrib>Dogbo, Odette</creatorcontrib><creatorcontrib>Camara, Bilal</creatorcontrib><title>Biosynthesis of the Food and Cosmetic Plant Pigment Bixin (Annatto)</title><title>Science (American Association for the Advancement of Science)</title><addtitle>Science</addtitle><description>Bixin, also known as annatto, is a seed-specific pigment widely used in foods and cosmetics since pre-Columbian times. We show that three genes from Bixa orellana, native to tropical America, govern bixin biosynthesis. These genes code for lycopene cleavage dioxygenase, bixin aldehyde dehydrogenase, and norbixin carboxyl methyltransferase, which catalyze the sequential conversion of lycopene into bixin. 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We show that three genes from Bixa orellana, native to tropical America, govern bixin biosynthesis. These genes code for lycopene cleavage dioxygenase, bixin aldehyde dehydrogenase, and norbixin carboxyl methyltransferase, which catalyze the sequential conversion of lycopene into bixin. Introduction of these three genes in Escherichia coli engineered to produce lycopene induced bixin synthesis, thus expanding the supply of this economically important plant product.</abstract><cop>Washington, DC</cop><pub>American Association for the Advancement of Science</pub><pmid>12829782</pmid><doi>10.1126/science.1085162</doi><tpages>3</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0036-8075 |
| ispartof | Science (American Association for the Advancement of Science), 2003-06, Vol.300 (5628), p.2089-2091 |
| issn | 0036-8075 1095-9203 |
| language | eng |
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| source | MEDLINE; American Association for the Advancement of Science; Jstor Complete Legacy |
| subjects | Aldehyde Dehydrogenase - chemistry Aldehyde Dehydrogenase - genetics Aldehyde Dehydrogenase - metabolism Aldehydes Amino Acid Sequence Amino acids Annatto Biological and medical sciences Biosynthesis Biotechnology Bixaceae - genetics Bixaceae - metabolism Carotenoids Carotenoids - biosynthesis Carotenoids - metabolism Catalysis Cloning, Molecular Coding Complementary DNA Dehydrogenases DNA, Complementary Enzymes Escherichia coli - genetics Escherichia coli - metabolism Flowers & plants Fundamental and applied biological sciences. Psychology Gene Library Genes Genes, Plant Genetic aspects Genetic engineering Genetic technics Methods. Procedures. Technologies Methyltransferases - chemistry Methyltransferases - genetics Methyltransferases - metabolism Modification of gene expression level Molecular Sequence Data Oxygenases - genetics Oxygenases - metabolism Pigments Plant pigments Recombinant Proteins - metabolism Scientific Concepts Seeds - genetics Sodium channels Transformation, Bacterial |
| title | Biosynthesis of the Food and Cosmetic Plant Pigment Bixin (Annatto) |
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