A Brief History of Drosophila's Contributions to Genome Research
The sequence of the Drosophila melanogaster genome presented in this issue of Science is the latest milestone in nine decades of research on this organism. Genetic and physical mapping, whole-genome mutational screens, and functional alteration of the genome by gene transfer were pioneered in metazo...
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| Veröffentlicht in: | Science (American Association for the Advancement of Science) 2000-03, Vol.287 (5461), p.2216-2218 |
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| container_title | Science (American Association for the Advancement of Science) |
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| creator | Rubin, Gerald M. Lewis, Edward B. |
| description | The sequence of the Drosophila melanogaster genome presented in this issue of Science is the latest milestone in nine decades of research on this organism. Genetic and physical mapping, whole-genome mutational screens, and functional alteration of the genome by gene transfer were pioneered in metazoans with the use of this small fruit fly. Here we look at some of the instances in which work on Drosophila has led to major conceptual or technical breakthroughs in our understanding of animal genomes. |
| doi_str_mv | 10.1126/science.287.5461.2216 |
| format | Article |
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| identifier | ISSN: 0036-8075 |
| ispartof | Science (American Association for the Advancement of Science), 2000-03, Vol.287 (5461), p.2216-2218 |
| issn | 0036-8075 1095-9203 |
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| subjects | Academic Achievement Animals Animals, Genetically Modified Chromosome mapping Chromosome Mapping - history Chromosomes Cloning, Molecular Computational Biology - history Drosophila Drosophila melanogaster - genetics Genes Genes, Insect Genetic research Genetic screening Genetics Genetics - history Genome Genomes Genomics Heredity History History of medicine History, 20th Century Insects Medical genetics Mutation Nobel Prize Phenotypes Physical Chromosome Mapping - history Recombination, Genetic Sequence Analysis, DNA Sequencing Viewpoints |
| title | A Brief History of Drosophila's Contributions to Genome Research |
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