Binding of GGA2 to the Lysosomal Enzyme Sorting Motif of the Mannose 6-Phosphate Receptor

The GGAs are a multidomain protein family implicated in protein trafficking between the Golgi and endosomes. Here, the VHS domain of GGA2 was shown to bind to the acidic cluster-dileucine motif in the cytoplasmic tail of the cation-independent mannose 6-phosphate receptor (CI-MPR). Receptors with mu...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 2001-06, Vol.292 (5522), p.1716-1718
Hauptverfasser:	Zhu, Yunxiang, Doray, Balraj, Poussu, Anssi, Lehto, Veli-Pekka, Kornfeld, Stuart
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Vesicular Transport Amino Acid Motifs Amino Acid Sequence Amino acids Animals Antibodies Biological and medical sciences Biomolecules Carrier Proteins Cations Cell lines Cell organelles Cell physiology Chimeras Clathrin - metabolism COS cells Developmental cytology Dipeptides - chemistry Dipeptides - metabolism Enzymes Formation Fundamental and applied biological sciences. Psychology L cells L Cells (Cell Line) Literary Devices Lysosomes - enzymology Membrane and intracellular transports Mice Molecular and cellular biology Molecular Sequence Data Mutation Organelles Protein Sorting Signals Protein Structure, Tertiary Protein Transport Proteins Proteins - chemistry Proteins - genetics Proteins - metabolism Rats Receptor, IGF Type 2 - chemistry Receptor, IGF Type 2 - genetics Receptor, IGF Type 2 - metabolism Receptors Recombinant Fusion Proteins - chemistry Recombinant Fusion Proteins - metabolism Solubility trans-Golgi Network - metabolism Transcription Factor AP-1 - metabolism Transport Vesicles - metabolism Two-Hybrid System Techniques Ungulates Yeasts
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