Bmf: A Proapoptotic BH3-Only Protein Regulated by Interaction with the Myosin V Actin Motor Complex, Activated by Anoikis
Bcl-2 family members bearing only the BH3 domain are essential inducers of apoptosis. We identified a BH3-only protein, Bmf, and show that its BH3 domain is required both for binding to prosurvival Bcl-2 proteins and for triggering apoptosis. In healthy cells, Bmf is sequestered to myosin V motors b...
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| Veröffentlicht in: | Science (American Association for the Advancement of Science) 2001-09, Vol.293 (5536), p.1829-1832 |
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| creator | Puthalakath, Hamsa Villunger, Andreas O'Reilly, Lorraine A. Beaumont, Jennifer G. Coultas, Leigh Cheney, Richard E. David C. S. Huang Strasser, Andreas |
| description | Bcl-2 family members bearing only the BH3 domain are essential inducers of apoptosis. We identified a BH3-only protein, Bmf, and show that its BH3 domain is required both for binding to prosurvival Bcl-2 proteins and for triggering apoptosis. In healthy cells, Bmf is sequestered to myosin V motors by association with dynein light chain 2. Certain damage signals, such as loss of cell attachment (anoikis), unleash Bmf, allowing it to translocate and bind prosurvival Bcl-2 proteins. Thus, at least two mammalian BH3-only proteins, Bmf and Bim, function to sense intracellular damage by their localization to distinct cytoskeletal structures. |
| doi_str_mv | 10.1126/science.1062257 |
| format | Article |
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Thus, at least two mammalian BH3-only proteins, Bmf and Bim, function to sense intracellular damage by their localization to distinct cytoskeletal structures.</description><identifier>ISSN: 0036-8075</identifier><identifier>EISSN: 1095-9203</identifier><identifier>DOI: 10.1126/science.1062257</identifier><identifier>PMID: 11546872</identifier><identifier>CODEN: SCIEAS</identifier><language>eng</language><publisher>Washington, DC: American Society for the Advancement of Science</publisher><subject>Adaptor Proteins, Signal Transducing ; Ageing, cell death ; Amino Acid Sequence ; Analysis ; Animals ; Anoikis ; Antibodies ; Apoptosis ; Apoptosis Regulatory Proteins ; Bcl-2-Like Protein 11 ; Biological and medical sciences ; Calmodulin-Binding Proteins - metabolism ; Carrier Proteins - chemistry ; Carrier Proteins - genetics ; Carrier Proteins - metabolism ; CDNA libraries ; Cell Line ; Cell lines ; Cell physiology ; Cells ; Cellular biology ; Cellulose nitrate ; Cytoskeleton - metabolism ; Developmental Stages ; Drosophila Proteins ; Dyneins ; Family (Sociological Unit) ; Family members ; Fundamental and applied biological sciences. Psychology ; Gene Expression Profiling ; Genetic aspects ; Genetic research ; HEK293 cells ; Humans ; Libraries ; Membrane Proteins ; Messenger RNA ; Mice ; Molecular and cellular biology ; Molecular Motor Proteins - metabolism ; Molecular Sequence Data ; Mutation ; Myeloid Cell Leukemia Sequence 1 Protein ; Myosin Type V ; Neoplasm Proteins - genetics ; Neoplasm Proteins - metabolism ; Nerve Tissue Proteins - metabolism ; Protein Binding ; Protein Structure, Tertiary ; Protein Transport ; Proteins ; Proto-Oncogene Proteins ; Proto-Oncogene Proteins c-bcl-2 - chemistry ; Proto-Oncogene Proteins c-bcl-2 - genetics ; Proto-Oncogene Proteins c-bcl-2 - metabolism ; RNA, Messenger - analysis ; RNA, Messenger - genetics ; Spleen cells ; Stimuli ; T lymphocytes ; Transfection ; Two-Hybrid System Techniques</subject><ispartof>Science (American Association for the Advancement of Science), 2001-09, Vol.293 (5536), p.1829-1832</ispartof><rights>Copyright 2001 American Association for the Advancement of Science</rights><rights>2002 INIST-CNRS</rights><rights>COPYRIGHT 2001 American Association for the Advancement of Science</rights><rights>COPYRIGHT 2001 American Association for the Advancement of Science</rights><rights>Copyright American Association for the Advancement of Science Sep 7, 2001</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c678t-1304523327fef8100c6906bfec471f526ab66514b6aff111e3518dbc9421ab083</citedby><cites>FETCH-LOGICAL-c678t-1304523327fef8100c6906bfec471f526ab66514b6aff111e3518dbc9421ab083</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/3084680$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/3084680$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,777,781,800,2871,2872,27905,27906,57998,58231</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14132079$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11546872$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Puthalakath, Hamsa</creatorcontrib><creatorcontrib>Villunger, Andreas</creatorcontrib><creatorcontrib>O'Reilly, Lorraine A.</creatorcontrib><creatorcontrib>Beaumont, Jennifer G.</creatorcontrib><creatorcontrib>Coultas, Leigh</creatorcontrib><creatorcontrib>Cheney, Richard E.</creatorcontrib><creatorcontrib>David C. S. Huang</creatorcontrib><creatorcontrib>Strasser, Andreas</creatorcontrib><title>Bmf: A Proapoptotic BH3-Only Protein Regulated by Interaction with the Myosin V Actin Motor Complex, Activated by Anoikis</title><title>Science (American Association for the Advancement of Science)</title><addtitle>Science</addtitle><description>Bcl-2 family members bearing only the BH3 domain are essential inducers of apoptosis. We identified a BH3-only protein, Bmf, and show that its BH3 domain is required both for binding to prosurvival Bcl-2 proteins and for triggering apoptosis. In healthy cells, Bmf is sequestered to myosin V motors by association with dynein light chain 2. Certain damage signals, such as loss of cell attachment (anoikis), unleash Bmf, allowing it to translocate and bind prosurvival Bcl-2 proteins. Thus, at least two mammalian BH3-only proteins, Bmf and Bim, function to sense intracellular damage by their localization to distinct cytoskeletal structures.</description><subject>Adaptor Proteins, Signal Transducing</subject><subject>Ageing, cell death</subject><subject>Amino Acid Sequence</subject><subject>Analysis</subject><subject>Animals</subject><subject>Anoikis</subject><subject>Antibodies</subject><subject>Apoptosis</subject><subject>Apoptosis Regulatory Proteins</subject><subject>Bcl-2-Like Protein 11</subject><subject>Biological and medical sciences</subject><subject>Calmodulin-Binding Proteins - metabolism</subject><subject>Carrier Proteins - chemistry</subject><subject>Carrier Proteins - genetics</subject><subject>Carrier Proteins - metabolism</subject><subject>CDNA libraries</subject><subject>Cell Line</subject><subject>Cell lines</subject><subject>Cell physiology</subject><subject>Cells</subject><subject>Cellular biology</subject><subject>Cellulose nitrate</subject><subject>Cytoskeleton - metabolism</subject><subject>Developmental Stages</subject><subject>Drosophila Proteins</subject><subject>Dyneins</subject><subject>Family (Sociological Unit)</subject><subject>Family members</subject><subject>Fundamental and applied biological sciences. 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Psychology</topic><topic>Gene Expression Profiling</topic><topic>Genetic aspects</topic><topic>Genetic research</topic><topic>HEK293 cells</topic><topic>Humans</topic><topic>Libraries</topic><topic>Membrane Proteins</topic><topic>Messenger RNA</topic><topic>Mice</topic><topic>Molecular and cellular biology</topic><topic>Molecular Motor Proteins - metabolism</topic><topic>Molecular Sequence Data</topic><topic>Mutation</topic><topic>Myeloid Cell Leukemia Sequence 1 Protein</topic><topic>Myosin Type V</topic><topic>Neoplasm Proteins - genetics</topic><topic>Neoplasm Proteins - metabolism</topic><topic>Nerve Tissue Proteins - metabolism</topic><topic>Protein Binding</topic><topic>Protein Structure, Tertiary</topic><topic>Protein Transport</topic><topic>Proteins</topic><topic>Proto-Oncogene Proteins</topic><topic>Proto-Oncogene Proteins c-bcl-2 - chemistry</topic><topic>Proto-Oncogene Proteins c-bcl-2 - genetics</topic><topic>Proto-Oncogene Proteins c-bcl-2 - metabolism</topic><topic>RNA, Messenger - analysis</topic><topic>RNA, Messenger - genetics</topic><topic>Spleen cells</topic><topic>Stimuli</topic><topic>T lymphocytes</topic><topic>Transfection</topic><topic>Two-Hybrid System Techniques</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Puthalakath, Hamsa</creatorcontrib><creatorcontrib>Villunger, Andreas</creatorcontrib><creatorcontrib>O'Reilly, Lorraine A.</creatorcontrib><creatorcontrib>Beaumont, Jennifer G.</creatorcontrib><creatorcontrib>Coultas, Leigh</creatorcontrib><creatorcontrib>Cheney, Richard E.</creatorcontrib><creatorcontrib>David C. 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S. Huang</au><au>Strasser, Andreas</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Bmf: A Proapoptotic BH3-Only Protein Regulated by Interaction with the Myosin V Actin Motor Complex, Activated by Anoikis</atitle><jtitle>Science (American Association for the Advancement of Science)</jtitle><addtitle>Science</addtitle><date>2001-09-07</date><risdate>2001</risdate><volume>293</volume><issue>5536</issue><spage>1829</spage><epage>1832</epage><pages>1829-1832</pages><issn>0036-8075</issn><eissn>1095-9203</eissn><coden>SCIEAS</coden><abstract>Bcl-2 family members bearing only the BH3 domain are essential inducers of apoptosis. We identified a BH3-only protein, Bmf, and show that its BH3 domain is required both for binding to prosurvival Bcl-2 proteins and for triggering apoptosis. In healthy cells, Bmf is sequestered to myosin V motors by association with dynein light chain 2. Certain damage signals, such as loss of cell attachment (anoikis), unleash Bmf, allowing it to translocate and bind prosurvival Bcl-2 proteins. Thus, at least two mammalian BH3-only proteins, Bmf and Bim, function to sense intracellular damage by their localization to distinct cytoskeletal structures.</abstract><cop>Washington, DC</cop><pub>American Society for the Advancement of Science</pub><pmid>11546872</pmid><doi>10.1126/science.1062257</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0036-8075 |
| ispartof | Science (American Association for the Advancement of Science), 2001-09, Vol.293 (5536), p.1829-1832 |
| issn | 0036-8075 1095-9203 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_743094869 |
| source | MEDLINE; American Association for the Advancement of Science; Jstor Complete Legacy |
| subjects | Adaptor Proteins, Signal Transducing Ageing, cell death Amino Acid Sequence Analysis Animals Anoikis Antibodies Apoptosis Apoptosis Regulatory Proteins Bcl-2-Like Protein 11 Biological and medical sciences Calmodulin-Binding Proteins - metabolism Carrier Proteins - chemistry Carrier Proteins - genetics Carrier Proteins - metabolism CDNA libraries Cell Line Cell lines Cell physiology Cells Cellular biology Cellulose nitrate Cytoskeleton - metabolism Developmental Stages Drosophila Proteins Dyneins Family (Sociological Unit) Family members Fundamental and applied biological sciences. Psychology Gene Expression Profiling Genetic aspects Genetic research HEK293 cells Humans Libraries Membrane Proteins Messenger RNA Mice Molecular and cellular biology Molecular Motor Proteins - metabolism Molecular Sequence Data Mutation Myeloid Cell Leukemia Sequence 1 Protein Myosin Type V Neoplasm Proteins - genetics Neoplasm Proteins - metabolism Nerve Tissue Proteins - metabolism Protein Binding Protein Structure, Tertiary Protein Transport Proteins Proto-Oncogene Proteins Proto-Oncogene Proteins c-bcl-2 - chemistry Proto-Oncogene Proteins c-bcl-2 - genetics Proto-Oncogene Proteins c-bcl-2 - metabolism RNA, Messenger - analysis RNA, Messenger - genetics Spleen cells Stimuli T lymphocytes Transfection Two-Hybrid System Techniques |
| title | Bmf: A Proapoptotic BH3-Only Protein Regulated by Interaction with the Myosin V Actin Motor Complex, Activated by Anoikis |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-17T22%3A32%3A45IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Bmf:%20A%20Proapoptotic%20BH3-Only%20Protein%20Regulated%20by%20Interaction%20with%20the%20Myosin%20V%20Actin%20Motor%20Complex,%20Activated%20by%20Anoikis&rft.jtitle=Science%20(American%20Association%20for%20the%20Advancement%20of%20Science)&rft.au=Puthalakath,%20Hamsa&rft.date=2001-09-07&rft.volume=293&rft.issue=5536&rft.spage=1829&rft.epage=1832&rft.pages=1829-1832&rft.issn=0036-8075&rft.eissn=1095-9203&rft.coden=SCIEAS&rft_id=info:doi/10.1126/science.1062257&rft_dat=%3Cgale_proqu%3EA78634294%3C/gale_proqu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=213564832&rft_id=info:pmid/11546872&rft_galeid=A78634294&rft_jstor_id=3084680&rfr_iscdi=true |