Bacterial Inhibitor of Host Programmed Cell Death Defenses Is an E3 Ubiquitin Ligase

The Pseudomonas syringae protein AvrPtoB is translocated into plant cells, where it inhibits immunity-associated programmed cell death (PCD). The structure of a C-terminal domain of AvrPtoB that is essential for anti-PCD activity reveals an unexpected homology to the U-box and RING-finger components...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 2006-01, Vol.311 (5758), p.222-226
Hauptverfasser:	Janjusevic, Radmila, Abramovitch, Robert B, Martin, Gregory B, Stebbins, C. Erec
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies Apoptosis Arabidopsis thaliana Bacteria bacterial diseases of plants Bacterial plant pathogens Bacterial Proteins - chemistry Bacterial Proteins - genetics Bacterial Proteins - metabolism Binding sites Biological and medical sciences Charge transfer devices Crop diseases defense mechanisms enzyme activity Enzymes Flowers & plants Fundamental and applied biological sciences. Psychology host-pathogen relationships Humans Immunity leaves Lycopersicon esculentum Lycopersicon esculentum - immunology Lycopersicon esculentum - microbiology Molecular Mimicry Mutagenesis Pathology. Damages, economic importance Phytopathology. Animal pests. Plant and forest protection Plant cells Plant Diseases - microbiology Plant Leaves - metabolism Plant Leaves - microbiology plant pathogenic bacteria Plant Proteins Protein Structure, Tertiary protein tertiary structure Protein-Serine-Threonine Kinases Proteins Pseudomonas syringae Pseudomonas syringae - enzymology Pseudomonas syringae - pathogenicity Pseudomonas syringae pv. tomato Recombinant Fusion Proteins - genetics Recombinant Fusion Proteins - metabolism Solanum lycopersicum var. lycopersicum Tomatoes Ubiquitin-Conjugating Enzymes - metabolism ubiquitin-protein ligase Ubiquitin-Protein Ligases - genetics Ubiquitin-Protein Ligases - metabolism Ubiquitins Virulence
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