EEA1 links PI(3)K function to Rab5 regulation of endosome fusion

GTPases and lipid kinases regulate membrane traffic along the endocytic pathway by mechanisms that are not completely understood. Fusion between early endosomes requires phosphatidyl-inositol-3-OH kinase (PI(3)K) activity as well as the small GTPase Rab5 (ref. 8). Excess Rab5-GTP complex restores en...

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Veröffentlicht in:	Nature (London) 1998-07, Vol.394 (6692), p.494-498
Hauptverfasser:	Stenmark, Harald, Simonsen, Anne, Lippe, Roger, Christoforidis, Savvas, Gaullier, Jean-Michel, Brech, Andreas, Callaghan, Judy, Toh, Ban-Hock, Murphy, Carol, Zerial, Marino
Format:	Artikel
Sprache:	eng
Schlagworte:	Androstadienes - pharmacology Animals Autoantigens - physiology Biochemistry Biological and medical sciences Cattle Cell Line Cell physiology Cloning, Molecular Cricetinae Endocytosis Endosomes - physiology Enzyme Inhibitors - pharmacology Fundamental and applied biological sciences. Psychology GTP-Binding Proteins - genetics GTP-Binding Proteins - physiology Guanosine Triphosphate - physiology HeLa Cells Humanities and Social Sciences Humans Intracellular Membranes - physiology letter Membrane Fusion - physiology Membrane Proteins - genetics Membrane Proteins - physiology Membranes Molecular and cellular biology multidisciplinary Mutagenesis Phosphatidylinositol 3-Kinases - antagonists & inhibitors Phosphatidylinositol 3-Kinases - physiology rab5 GTP-Binding Proteins Recombinant Fusion Proteins - metabolism Science Science (multidisciplinary) Vesicular Transport Proteins
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