A human recombinant haemoglobin designed for use as a blood substitute

THE need to develop a blood substitute is now urgent because of the increasing concern over blood-transmitted viral and bacterial pathogens 1 . Cell-free haemoglobin solutions 2,3 and human haemoglobin synthesized in Escherichia coli 4 and Saccharomyces cerevisiae 5 have been investigated as potenti...

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Veröffentlicht in:	Nature (London) 1992-03, Vol.356 (6366), p.258-260
Hauptverfasser:	Looker, Douglas, Abbott-Brown, Debbie, Cozart, Paul, Durfee, Steven, Hoffman, Stephen, Mathews, Antony J, Miller-Roehrkh, Jeanne, Shoemaker, Steven, Trimble, Stephen, Fermi, Giuilio, Komiyama, Noboru H, Nagai, Kiyoshi, Stetler, Gary L
Format:	Artikel
Sprache:	eng
Schlagworte:	affinity Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Animals beta -globin Biochemistry Biological and medical sciences Biotechnology Blood Blood Substitutes - adverse effects Blood. Blood and plasma substitutes. Blood products. Blood cells. Blood typing. Plasmapheresis. Apheresis Crystallization E coli Escherichia coli - genetics expression genes Globins - genetics Globins - metabolism haemoglobin Half-Life Hemoglobins - biosynthesis Hemoglobins - genetics Hemoglobins - metabolism Humanities and Social Sciences Humans Kidney Diseases - chemically induced letter Macromolecular Substances man Medical sciences Molecular Structure multidisciplinary Mutation Oxygen Oxygen - metabolism Pathogens production Rats Rats, Inbred Strains Recombinant Fusion Proteins - adverse effects Recombinant Fusion Proteins - biosynthesis Recombinant Fusion Proteins - metabolism recombinants Science Science (multidisciplinary) Transfusions. Complications. Transfusion reactions. Cell and gene therapy vectors
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