Different domains of synaptotagmin control the choice between kiss-and-run and full fusion

Exocytosis-the release of the contents of a vesicle-proceeds by two mechanisms. Full fusion occurs when the vesicle and plasma membranes merge. Alternatively, in what is termed kiss-and-run, vesicles can release transmitter during transient contacts with the plasma membrane. Little is known at the m...

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Veröffentlicht in:	Nature 2003-08, Vol.424 (6951), p.943-947
Hauptverfasser:	Jackson, Meyer B, Wang, Chih-Tien, Lu, Juu-Chin, Bai, Jihong, Chang, Payne Y, Martin, Thomas F. J, Chapman, Edwin R
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Binding Sites Biological and medical sciences Calcium - metabolism Calcium-Binding Proteins Cell Membrane - metabolism Cell Membrane Permeability Cell physiology Colforsin - pharmacology Exocytosis Fundamental and applied biological sciences. Psychology Fusion Ligands Membrane Fusion Membrane Glycoproteins - chemistry Membrane Glycoproteins - genetics Membrane Glycoproteins - metabolism Membranes Molecular and cellular biology Mutation Mutation - genetics Nerve Tissue Proteins - chemistry Nerve Tissue Proteins - genetics Nerve Tissue Proteins - metabolism PC12 Cells Plasma Protein Binding Protein Structure, Tertiary Rats Secretion. Exocytosis Synaptotagmins
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