Effect of Salicylate on the Rectal Absorption of Lidocaine, Levodopa, and Cefmetazole in Rats

Salicylic acid and sodium salicylate have been found to enhance the absorption of lidocaine, levodopa, and cefmetazole after rectal administration to rats. These drugs represent a base (lidocaine), an acid (cefmetazole), and a substance (levodopa) which exists as a zwitterion in solution. The rectal...

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Veröffentlicht in:	Journal of pharmaceutical sciences 1982-08, Vol.71 (8), p.869-872
Hauptverfasser:	Nishihata, Toshiaki, Howard Rytting, J., Higuchi, Takeru
Format:	Artikel
Sprache:	eng
Schlagworte:	Absorption Absorption, rectal—effect of salicylate on rectal absorption of lidocaine, levodopa, and cefmetazole, rats and cefmetazole Animals Biological Availability Cefmetazole Cefmetazole-effect of salicylate on rectal absorption Cefmetazole—effect of salicylate on rectal absorption, rats Cephalosporins - metabolism Cephamycins - metabolism Infusions, Parenteral Intestinal Absorption - drug effects levodopa Levodopa - metabolism Levodopa-effect of salicylate on rectal absorption Levodopa— effect of salicylate on rectal absorption, rats Lidocaine - metabolism Lidocaine-effect of salicylate on rectal absorption Lidocaine—effect of salicylate on rectal absorption, rats Male Rats Rats, Inbred Strains rectal-effect of salicylate on rectal absorption of lidocaine Rectum - metabolism Salicylate-effect on rectal absorption of lidocaine Salicylates - pharmacology Salicylate—effect on rectal absorption of lidocaine, levodopa, and cefmetazole, rats Salicylic Acid Stimulation, Chemical
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