Interaction of beta-endorphin and other opioid peptides with calmodulin

A highly purified preparation of calmodulin activated a calmodulin-deficient phosphodiesterase by more than 10-fold. This activation of phosphodiesterase by calmodulin was completely inhibited by two opioid peptides, beta-endorphin and dynorphin, at concentrations that had no appreciable effect on t...

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Veröffentlicht in:	Molecular pharmacology 1982-01, Vol.21 (1), p.86-91
Hauptverfasser:	M Sellinger-Barnette, B Weiss
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals beta-Endorphin Binding, Competitive Biotransformation - drug effects Calcium-Binding Proteins - metabolism Calmodulin - metabolism Cattle Chlorpromazine - pharmacology Endorphins - pharmacology Enkephalin, Methionine - pharmacology Enzyme Activation - drug effects In Vitro Techniques Phosphoric Diester Hydrolases - metabolism
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