A common human anti-hepatitis B surface antigen idiotype is associated with the group a conformation-dependent antigenic determinant

Human antibodies that express a common anti-hepatitis B surface antigen idiotype were directed against the group-specific a determinant. The ability of hepatitis B surface antigen (HBsAg)-derived polypeptides to inhibit the idiotype-anti-idiotype reaction was dependent on conformation, since denatur...

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Veröffentlicht in:	Virology (New York, N.Y.) N.Y.), 1982-10, Vol.122 (1), p.219-221
Hauptverfasser:	Kennedy, Ronald C., Sanchez, Yanuario, Ionescu-Matiu, Irina, Melnick, Joseph L., Dreesman, Gordon R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Epitopes Hepatitis B Surface Antigens - immunology Immunoglobulin Idiotypes Protein Conformation Structure-Activity Relationship
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creator	Kennedy, Ronald C. Sanchez, Yanuario Ionescu-Matiu, Irina Melnick, Joseph L. Dreesman, Gordon R.
description	Human antibodies that express a common anti-hepatitis B surface antigen idiotype were directed against the group-specific a determinant. The ability of hepatitis B surface antigen (HBsAg)-derived polypeptides to inhibit the idiotype-anti-idiotype reaction was dependent on conformation, since denatured HBsAg viral polypeptides virtually lost their inhibitor capacity when compared to native polypeptides. This report further characterizes a common idiotype associated with human antibodies to HBsAg.
doi_str_mv	10.1016/0042-6822(82)90394-4
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source	Elsevier ScienceDirect Journals Complete - AutoHoldings; MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals
subjects	Epitopes Hepatitis B Surface Antigens - immunology Immunoglobulin Idiotypes Protein Conformation Structure-Activity Relationship
title	A common human anti-hepatitis B surface antigen idiotype is associated with the group a conformation-dependent antigenic determinant
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