Kinetic analysis of differences in brain acetylcholinesterase from fish or mammalian sources

A kinetic analysis of the interactions of gold fish and rat brain AChE (acetylcholine acetylhydrolase, EC 3.1.1.7) with acetylthiocholine substrate and sulfonyl fluoride inhibitors revealed several differences between these enzymes. The fish brain AChE had a K m of 250 μM while the mammalian brain A...

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Veröffentlicht in:	Biochemical pharmacology 1978, Vol.27 (23), p.2693-2698
Hauptverfasser:	Moss, Donald E., Fahrney, David
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholinesterase - metabolism Animals Brain - enzymology Cholinesterase Inhibitors Fishes - metabolism In Vitro Techniques Kinetics Mesylates - pharmacology Neuromuscular Depolarizing Agents - pharmacology Neuromuscular Nondepolarizing Agents - pharmacology Rats Species Specificity Substrate Specificity
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