Long-Term Clinical Effects, Bioavailability, and Kinetics of Minoxidil in Relation to Renal Function
Minoxidil was used to treat 26 patients (17 to 67 years old) with severe hypertension and varying degrees of renal function. Our object was to assess long-term clinical efficacy, kinetics (acute and chronic), and bioavailability of minoxidil in chronic renal insufficiency. Minoxidil, 27 to 30 mg per...
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| Veröffentlicht in: | Journal of clinical pharmacology 1978-10, Vol.18 (10), p.500-508 |
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| creator | LOWENTHAL, DAVID T. ONESTI, GADDO MUTTERPERL, ROBERT APFRIME, MELTON MARTINEZ, EDUARDO W. KIM, KWAN E. BUSBY, PATRICIA SHIRK, JANE SWARTZ, CHARLES |
| description | Minoxidil was used to treat 26 patients (17 to 67 years old) with severe hypertension and varying degrees of renal function. Our object was to assess long-term clinical efficacy, kinetics (acute and chronic), and bioavailability of minoxidil in chronic renal insufficiency. Minoxidil, 27 to 30 mg per day, decreased systolic and diastolic blood pressure during the first three months of therapy. Between the third and 24th months (30 months in one patient) there was no further change. Propranolol or clonidine was needed to control heart rate, and furosemide or dialysis was needed to control edema induced by minoxidil. Renal function improved in some of the mildy azotemic patients. Minoxidil kinetics after the customary dose did not differ whether the drug was taken as tablet or solution. Kinetic parameters during chronic administration of minoxidil did not differ from those after acute administration. The kinetics in chronic renal insufficiency do not differ from these in subjects with normal renal function. |
| doi_str_mv | 10.1002/j.1552-4604.1978.tb01578.x |
| format | Article |
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Our object was to assess long-term clinical efficacy, kinetics (acute and chronic), and bioavailability of minoxidil in chronic renal insufficiency. Minoxidil, 27 to 30 mg per day, decreased systolic and diastolic blood pressure during the first three months of therapy. Between the third and 24th months (30 months in one patient) there was no further change. Propranolol or clonidine was needed to control heart rate, and furosemide or dialysis was needed to control edema induced by minoxidil. Renal function improved in some of the mildy azotemic patients. Minoxidil kinetics after the customary dose did not differ whether the drug was taken as tablet or solution. Kinetic parameters during chronic administration of minoxidil did not differ from those after acute administration. The kinetics in chronic renal insufficiency do not differ from these in subjects with normal renal function.</description><identifier>ISSN: 0091-2700</identifier><identifier>EISSN: 1552-4604</identifier><identifier>DOI: 10.1002/j.1552-4604.1978.tb01578.x</identifier><identifier>PMID: 361764</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Adolescent ; Adult ; Aged ; Biological Availability ; Blood Pressure - drug effects ; Clinical Trials as Topic ; Female ; Humans ; Hypertension - complications ; Hypertension - drug therapy ; Kidney - physiology ; Kidney Diseases - complications ; Kidney Diseases - metabolism ; Kidney Diseases - physiopathology ; Kinetics ; Male ; Middle Aged ; Minoxidil - metabolism ; Minoxidil - therapeutic use ; Propranolol - blood ; Pyrimidines - metabolism</subject><ispartof>Journal of clinical pharmacology, 1978-10, Vol.18 (10), p.500-508</ispartof><rights>1978 American College of Clinical Pharmacology</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4088-c57bf3cb0712bbc711f6eb34a91c1505630eda3fc1554bae40baf6a4e430e1bf3</citedby><cites>FETCH-LOGICAL-c4088-c57bf3cb0712bbc711f6eb34a91c1505630eda3fc1554bae40baf6a4e430e1bf3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fj.1552-4604.1978.tb01578.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fj.1552-4604.1978.tb01578.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27903,27904,45553,45554</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/361764$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>LOWENTHAL, DAVID T.</creatorcontrib><creatorcontrib>ONESTI, GADDO</creatorcontrib><creatorcontrib>MUTTERPERL, ROBERT</creatorcontrib><creatorcontrib>APFRIME, MELTON</creatorcontrib><creatorcontrib>MARTINEZ, EDUARDO W.</creatorcontrib><creatorcontrib>KIM, KWAN E.</creatorcontrib><creatorcontrib>BUSBY, PATRICIA</creatorcontrib><creatorcontrib>SHIRK, JANE</creatorcontrib><creatorcontrib>SWARTZ, CHARLES</creatorcontrib><title>Long-Term Clinical Effects, Bioavailability, and Kinetics of Minoxidil in Relation to Renal Function</title><title>Journal of clinical pharmacology</title><addtitle>J Clin Pharmacol</addtitle><description>Minoxidil was used to treat 26 patients (17 to 67 years old) with severe hypertension and varying degrees of renal function. Our object was to assess long-term clinical efficacy, kinetics (acute and chronic), and bioavailability of minoxidil in chronic renal insufficiency. Minoxidil, 27 to 30 mg per day, decreased systolic and diastolic blood pressure during the first three months of therapy. Between the third and 24th months (30 months in one patient) there was no further change. Propranolol or clonidine was needed to control heart rate, and furosemide or dialysis was needed to control edema induced by minoxidil. Renal function improved in some of the mildy azotemic patients. Minoxidil kinetics after the customary dose did not differ whether the drug was taken as tablet or solution. Kinetic parameters during chronic administration of minoxidil did not differ from those after acute administration. The kinetics in chronic renal insufficiency do not differ from these in subjects with normal renal function.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Biological Availability</subject><subject>Blood Pressure - drug effects</subject><subject>Clinical Trials as Topic</subject><subject>Female</subject><subject>Humans</subject><subject>Hypertension - complications</subject><subject>Hypertension - drug therapy</subject><subject>Kidney - physiology</subject><subject>Kidney Diseases - complications</subject><subject>Kidney Diseases - metabolism</subject><subject>Kidney Diseases - physiopathology</subject><subject>Kinetics</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Minoxidil - metabolism</subject><subject>Minoxidil - therapeutic use</subject><subject>Propranolol - blood</subject><subject>Pyrimidines - metabolism</subject><issn>0091-2700</issn><issn>1552-4604</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1978</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkE2P0zAQhi3EV1n4BxwsDpw2ZZz4I-UEVPsBlKWgRUhcLNuxkYtrL3EK7b_HUareOc3Y78wz0oPQCwJzAlC_2swJY3VFOdA5WYh2PmggrNT9PTQ7RffRDGBBqloAPEZPct4AEE4ZeYQeNpwITmeoW6X4s7q1_RYvg4_eqIAvnLNmyOf4nU_qj_JBaR_8cDjHKnb4o4928Cbj5PAnH9Pedz5gH_FXG9TgU8RDKn0soMtdNOPPU_TAqZDts2M9Q98uL26X19Xq89X75dtVZSi0bWWY0K4xGgSptTaCEMetbqhaEEMYMN6A7VTjyoNRrSwFrRxX1NISkLJ6hl5O3Ls-_d7ZPMitz8aGoKJNuywFrdsFJ1AGX0-Dpk8599bJu95vVX-QBORoWG7kqFGOGuVoWB4Ny31Zfn68stNb251WJ6UlfjPFf32wh_8Ayw_L9fXYFkQ1IXwe7P6EUP0vyUUjmPx-cyXpzZr9WPNWfmn-AYbIm4Y</recordid><startdate>197810</startdate><enddate>197810</enddate><creator>LOWENTHAL, DAVID T.</creator><creator>ONESTI, GADDO</creator><creator>MUTTERPERL, ROBERT</creator><creator>APFRIME, MELTON</creator><creator>MARTINEZ, EDUARDO W.</creator><creator>KIM, KWAN E.</creator><creator>BUSBY, PATRICIA</creator><creator>SHIRK, JANE</creator><creator>SWARTZ, CHARLES</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>197810</creationdate><title>Long-Term Clinical Effects, Bioavailability, and Kinetics of Minoxidil in Relation to Renal Function</title><author>LOWENTHAL, DAVID T. ; ONESTI, GADDO ; MUTTERPERL, ROBERT ; APFRIME, MELTON ; MARTINEZ, EDUARDO W. ; KIM, KWAN E. ; BUSBY, PATRICIA ; SHIRK, JANE ; SWARTZ, CHARLES</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4088-c57bf3cb0712bbc711f6eb34a91c1505630eda3fc1554bae40baf6a4e430e1bf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1978</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Biological Availability</topic><topic>Blood Pressure - drug effects</topic><topic>Clinical Trials as Topic</topic><topic>Female</topic><topic>Humans</topic><topic>Hypertension - complications</topic><topic>Hypertension - drug therapy</topic><topic>Kidney - physiology</topic><topic>Kidney Diseases - complications</topic><topic>Kidney Diseases - metabolism</topic><topic>Kidney Diseases - physiopathology</topic><topic>Kinetics</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Minoxidil - metabolism</topic><topic>Minoxidil - therapeutic use</topic><topic>Propranolol - blood</topic><topic>Pyrimidines - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>LOWENTHAL, DAVID T.</creatorcontrib><creatorcontrib>ONESTI, GADDO</creatorcontrib><creatorcontrib>MUTTERPERL, ROBERT</creatorcontrib><creatorcontrib>APFRIME, MELTON</creatorcontrib><creatorcontrib>MARTINEZ, EDUARDO W.</creatorcontrib><creatorcontrib>KIM, KWAN E.</creatorcontrib><creatorcontrib>BUSBY, PATRICIA</creatorcontrib><creatorcontrib>SHIRK, JANE</creatorcontrib><creatorcontrib>SWARTZ, CHARLES</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of clinical pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>LOWENTHAL, DAVID T.</au><au>ONESTI, GADDO</au><au>MUTTERPERL, ROBERT</au><au>APFRIME, MELTON</au><au>MARTINEZ, EDUARDO W.</au><au>KIM, KWAN E.</au><au>BUSBY, PATRICIA</au><au>SHIRK, JANE</au><au>SWARTZ, CHARLES</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Long-Term Clinical Effects, Bioavailability, and Kinetics of Minoxidil in Relation to Renal Function</atitle><jtitle>Journal of clinical pharmacology</jtitle><addtitle>J Clin Pharmacol</addtitle><date>1978-10</date><risdate>1978</risdate><volume>18</volume><issue>10</issue><spage>500</spage><epage>508</epage><pages>500-508</pages><issn>0091-2700</issn><eissn>1552-4604</eissn><abstract>Minoxidil was used to treat 26 patients (17 to 67 years old) with severe hypertension and varying degrees of renal function. Our object was to assess long-term clinical efficacy, kinetics (acute and chronic), and bioavailability of minoxidil in chronic renal insufficiency. Minoxidil, 27 to 30 mg per day, decreased systolic and diastolic blood pressure during the first three months of therapy. Between the third and 24th months (30 months in one patient) there was no further change. Propranolol or clonidine was needed to control heart rate, and furosemide or dialysis was needed to control edema induced by minoxidil. Renal function improved in some of the mildy azotemic patients. Minoxidil kinetics after the customary dose did not differ whether the drug was taken as tablet or solution. Kinetic parameters during chronic administration of minoxidil did not differ from those after acute administration. The kinetics in chronic renal insufficiency do not differ from these in subjects with normal renal function.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>361764</pmid><doi>10.1002/j.1552-4604.1978.tb01578.x</doi><tpages>9</tpages></addata></record> |
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| ispartof | Journal of clinical pharmacology, 1978-10, Vol.18 (10), p.500-508 |
| issn | 0091-2700 1552-4604 |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Adolescent Adult Aged Biological Availability Blood Pressure - drug effects Clinical Trials as Topic Female Humans Hypertension - complications Hypertension - drug therapy Kidney - physiology Kidney Diseases - complications Kidney Diseases - metabolism Kidney Diseases - physiopathology Kinetics Male Middle Aged Minoxidil - metabolism Minoxidil - therapeutic use Propranolol - blood Pyrimidines - metabolism |
| title | Long-Term Clinical Effects, Bioavailability, and Kinetics of Minoxidil in Relation to Renal Function |
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