DETERMINING THE EFFECTIVE EMETIC DOSAGE OF TETRAPOTASSIUM PYROPHOSPHATE (TKPP) IN DOGS

The effect of TKPP on emesis was examined in adult "conditioned random source" mongrel dogs. Only dogs that exhibited emesis with CuSO4 were used. The effect of dosage and concentration of TKPP on emesis was highly significant. The effective combinations of dose and concentration were 4, 8...

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Veröffentlicht in:	Journal of toxicological sciences 1982/06/25, Vol.7(2), pp.151-158
Hauptverfasser:	AKAHORI, Fumiaki, MASAOKA, Toshio, AKIYAMA, Eri
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Diphosphates - administration & dosage Dogs Dose-Response Relationship, Drug Effective emetic dosage of TKPP Emetics - administration & dosage Female Male Potassium - administration & dosage Potassium Compounds Reaction Time
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container_title	Journal of toxicological sciences
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creator	AKAHORI, Fumiaki MASAOKA, Toshio AKIYAMA, Eri
description	The effect of TKPP on emesis was examined in adult "conditioned random source" mongrel dogs. Only dogs that exhibited emesis with CuSO4 were used. The effect of dosage and concentration of TKPP on emesis was highly significant. The effective combinations of dose and concentration were 4, 800, 2, 400, or 1, 200 mg/head at 5, 10, or 20%. In all the tested dogs, 4, 800mg of 20% TKPP was effective inducing emesis. The mean latency of emesis in dogs was 7 min, 33 sec (95% confidence limits : 5 min, 58 sec-9 min, 7 sec).
doi_str_mv	10.2131/jts.7.151
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subjects	Animals Diphosphates - administration & dosage Dogs Dose-Response Relationship, Drug Effective emetic dosage of TKPP Emetics - administration & dosage Female Male Potassium - administration & dosage Potassium Compounds Reaction Time
title	DETERMINING THE EFFECTIVE EMETIC DOSAGE OF TETRAPOTASSIUM PYROPHOSPHATE (TKPP) IN DOGS
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