Mucus-producing medullary cell carcinoma of the thyroid gland
A case of medullary carcinoma of the thyroid with the presence of mucus-secreting (goblet) cells was reported. Ultrastructurally, the tumor was composed of two types of cells, one with neurosecretory granules and the other with mucus granules. The secretion of calcitonin and mucus was demonstrated b...
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| Veröffentlicht in: | American journal of clinical pathology 1982-10, Vol.78 (4), p.536-540 |
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| container_title | American journal of clinical pathology |
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| creator | Fernandes, B J Bedard, Y C Rosen, I |
| description | A case of medullary carcinoma of the thyroid with the presence of mucus-secreting (goblet) cells was reported. Ultrastructurally, the tumor was composed of two types of cells, one with neurosecretory granules and the other with mucus granules. The secretion of calcitonin and mucus was demonstrated by histochemical methods. The presence of two cell populations in this tumor casts doubts on the "APUD" concept, which proposes a neuroectodermal origin for parafollicular (C) cells of the thyroid gland. The significance of this tumor with regard to the histogenesis of the cells involved, is discussed. |
| doi_str_mv | 10.1093/ajcp/78.4.536 |
| format | Article |
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Ultrastructurally, the tumor was composed of two types of cells, one with neurosecretory granules and the other with mucus granules. The secretion of calcitonin and mucus was demonstrated by histochemical methods. The presence of two cell populations in this tumor casts doubts on the "APUD" concept, which proposes a neuroectodermal origin for parafollicular (C) cells of the thyroid gland. 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Ultrastructurally, the tumor was composed of two types of cells, one with neurosecretory granules and the other with mucus granules. The secretion of calcitonin and mucus was demonstrated by histochemical methods. The presence of two cell populations in this tumor casts doubts on the "APUD" concept, which proposes a neuroectodermal origin for parafollicular (C) cells of the thyroid gland. The significance of this tumor with regard to the histogenesis of the cells involved, is discussed.</description><subject>Adult</subject><subject>Calcitonin - analysis</subject><subject>Carcinoma - diagnosis</subject><subject>Carcinoma - pathology</subject><subject>Carcinoma - ultrastructure</subject><subject>Humans</subject><subject>Lymph Nodes - pathology</subject><subject>Male</subject><subject>Mucus - metabolism</subject><subject>Thyroid Neoplasms - diagnosis</subject><subject>Thyroid Neoplasms - pathology</subject><subject>Thyroid Neoplasms - ultrastructure</subject><issn>0002-9173</issn><issn>1943-7722</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1982</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kDtLA0EURgdRYoyWlsJWdpPceew8CgsRXxCx0XqYnUfcsJuNM9ki_94JCRaXC5fDx3cPQrcE5gQ0W9i12y6kmvN5zcQZmhLNGZaS0nM0BQCKNZHsEl3lvAYgVAGfoIkkTIKSU_TwMbox420a_Ojazarqgx-7zqZ95ULXVc6mch56Ww2x2v2EMvs0tL5adXbjr9FFtF0ON6c9Q98vz19Pb3j5-fr-9LjEjlG5w5pF7RrrvRaU68ilEJE3vHZeeA5NTXUkVniitK8tyCAESKKkUwq0CkyxGbo_5paev2PIO9O3-dDPbsIwZiM5VbWuoYD4CLo05JxCNNvU9uUbQ8AcdJmDLiOV4aboKvzdKXhsyuf_9MkP-wOlW2W1</recordid><startdate>198210</startdate><enddate>198210</enddate><creator>Fernandes, B J</creator><creator>Bedard, Y C</creator><creator>Rosen, I</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198210</creationdate><title>Mucus-producing medullary cell carcinoma of the thyroid gland</title><author>Fernandes, B J ; Bedard, Y C ; Rosen, I</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c327t-93f9cbadd96249f4766f4b45cd6d40b529f1a6d189d5a07e6607187c88098e383</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1982</creationdate><topic>Adult</topic><topic>Calcitonin - analysis</topic><topic>Carcinoma - diagnosis</topic><topic>Carcinoma - pathology</topic><topic>Carcinoma - ultrastructure</topic><topic>Humans</topic><topic>Lymph Nodes - pathology</topic><topic>Male</topic><topic>Mucus - metabolism</topic><topic>Thyroid Neoplasms - diagnosis</topic><topic>Thyroid Neoplasms - pathology</topic><topic>Thyroid Neoplasms - ultrastructure</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fernandes, B J</creatorcontrib><creatorcontrib>Bedard, Y C</creatorcontrib><creatorcontrib>Rosen, I</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of clinical pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fernandes, B J</au><au>Bedard, Y C</au><au>Rosen, I</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mucus-producing medullary cell carcinoma of the thyroid gland</atitle><jtitle>American journal of clinical pathology</jtitle><addtitle>Am J Clin Pathol</addtitle><date>1982-10</date><risdate>1982</risdate><volume>78</volume><issue>4</issue><spage>536</spage><epage>540</epage><pages>536-540</pages><issn>0002-9173</issn><eissn>1943-7722</eissn><abstract>A case of medullary carcinoma of the thyroid with the presence of mucus-secreting (goblet) cells was reported. 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| fulltext | fulltext |
| identifier | ISSN: 0002-9173 |
| ispartof | American journal of clinical pathology, 1982-10, Vol.78 (4), p.536-540 |
| issn | 0002-9173 1943-7722 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_74285950 |
| source | Oxford University Press Journals Digital Archive legacy; MEDLINE |
| subjects | Adult Calcitonin - analysis Carcinoma - diagnosis Carcinoma - pathology Carcinoma - ultrastructure Humans Lymph Nodes - pathology Male Mucus - metabolism Thyroid Neoplasms - diagnosis Thyroid Neoplasms - pathology Thyroid Neoplasms - ultrastructure |
| title | Mucus-producing medullary cell carcinoma of the thyroid gland |
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