A new approach to the difficult assessment of aldosterone secretion in anephric patients
A new method for the assessment of endogenous formation of aldosterone in anephric patients is described. (1, 2- 3H) aldosterone was administered i.v. to patients 1–2 days before hemodialysis, and then the specific activity (SA) of tetrahydroaldosterone glucosiduronate, the major aldosterone metabol...
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| Veröffentlicht in: | Steroids 1978-11, Vol.32 (4), p.487-498 |
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| creator | Pratt, J.H. Parkinson, C.A. Luft, F.C. |
| description | A new method for the assessment of endogenous formation of aldosterone in anephric patients is described. (1, 2-
3H) aldosterone was administered i.v. to patients 1–2 days before hemodialysis, and then the specific activity (SA) of tetrahydroaldosterone glucosiduronate, the major aldosterone metabolite, was measured in the dialysate using a specific radioimmunoassay. The aldosterone secretion rate was determined from the extent of isotope dilution by endogenous metabolite.
Aldosterone secretion rates measured in 10 patients were for the most part low. The secretion rate determined in blood from the aldosterone metabolic clearance rate and plasma aldosterone concentration closely approximate secretion rate values obtained by the isotope dilution method in 3 of 4 patients.
In 2 patients in whom ACTH was administered chronically, radio-labeled aldosterone was administered at the start of the study and then the day to day aldosterone secretory response to ACTH was determined from the SA of tetrahydroaldosterone in blood. Aldosterone secretion continuously increased for as long as ACTH was administered |
| doi_str_mv | 10.1016/0039-128X(78)90060-0 |
| format | Article |
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3H) aldosterone was administered i.v. to patients 1–2 days before hemodialysis, and then the specific activity (SA) of tetrahydroaldosterone glucosiduronate, the major aldosterone metabolite, was measured in the dialysate using a specific radioimmunoassay. The aldosterone secretion rate was determined from the extent of isotope dilution by endogenous metabolite.
Aldosterone secretion rates measured in 10 patients were for the most part low. The secretion rate determined in blood from the aldosterone metabolic clearance rate and plasma aldosterone concentration closely approximate secretion rate values obtained by the isotope dilution method in 3 of 4 patients.
In 2 patients in whom ACTH was administered chronically, radio-labeled aldosterone was administered at the start of the study and then the day to day aldosterone secretory response to ACTH was determined from the SA of tetrahydroaldosterone in blood. Aldosterone secretion continuously increased for as long as ACTH was administered</description><identifier>ISSN: 0039-128X</identifier><identifier>EISSN: 1878-5867</identifier><identifier>DOI: 10.1016/0039-128X(78)90060-0</identifier><identifier>PMID: 214904</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adolescent ; Adrenocorticotropic Hormone ; Adult ; Aldosterone - analogs & derivatives ; Aldosterone - blood ; Female ; Glucuronates - blood ; Humans ; Male ; Nephrectomy ; Potassium - blood ; Radioimmunoassay - methods ; Renal Dialysis</subject><ispartof>Steroids, 1978-11, Vol.32 (4), p.487-498</ispartof><rights>1978</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c356t-b032efedec8173bdbe999ccbdd6d9f2f69ec3f07e7121d16726dcf88f0d30cf13</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/0039128X78900600$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/214904$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pratt, J.H.</creatorcontrib><creatorcontrib>Parkinson, C.A.</creatorcontrib><creatorcontrib>Luft, F.C.</creatorcontrib><title>A new approach to the difficult assessment of aldosterone secretion in anephric patients</title><title>Steroids</title><addtitle>Steroids</addtitle><description>A new method for the assessment of endogenous formation of aldosterone in anephric patients is described. (1, 2-
3H) aldosterone was administered i.v. to patients 1–2 days before hemodialysis, and then the specific activity (SA) of tetrahydroaldosterone glucosiduronate, the major aldosterone metabolite, was measured in the dialysate using a specific radioimmunoassay. The aldosterone secretion rate was determined from the extent of isotope dilution by endogenous metabolite.
Aldosterone secretion rates measured in 10 patients were for the most part low. The secretion rate determined in blood from the aldosterone metabolic clearance rate and plasma aldosterone concentration closely approximate secretion rate values obtained by the isotope dilution method in 3 of 4 patients.
In 2 patients in whom ACTH was administered chronically, radio-labeled aldosterone was administered at the start of the study and then the day to day aldosterone secretory response to ACTH was determined from the SA of tetrahydroaldosterone in blood. Aldosterone secretion continuously increased for as long as ACTH was administered</description><subject>Adolescent</subject><subject>Adrenocorticotropic Hormone</subject><subject>Adult</subject><subject>Aldosterone - analogs & derivatives</subject><subject>Aldosterone - blood</subject><subject>Female</subject><subject>Glucuronates - blood</subject><subject>Humans</subject><subject>Male</subject><subject>Nephrectomy</subject><subject>Potassium - blood</subject><subject>Radioimmunoassay - methods</subject><subject>Renal Dialysis</subject><issn>0039-128X</issn><issn>1878-5867</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1978</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEtLAzEUhYP4qtV_0EVWoovRZDKdJBuhFF9QcKPQXZhJbmhkOhmTVPHfm9ri0ru5i3vO4Z4PoQklN5TQ-pYQJgtaiuUVF9eSkJoU5ACNqOCimIqaH6LRn-QUncX4TrKIyfIEHZe0kqQaoeUM9_CFm2EIvtErnDxOK8DGWev0pku4iRFiXEOfsLe46YyPCYLvAUfQAZLzPXY9bnoYVsFpPDTJZXE8R0e26SJc7PcYvT3cv86fisXL4_N8tig0m9apaAkrwYIBLShnrWlBSql1a0xtpC1tLUEzSzhwWlJDa17WRlshLDGMaEvZGF3ucnOBjw3EpNYuaui6_JHfRMWrklOWZ4yqnVAHH2MAq4bg1k34VpSoLU-1haW2sBQX6penItk22edv2jWYP9MOYD7f7c6QO346CCrq3F-DcQF0Usa7__N_AFNOhtI</recordid><startdate>197811</startdate><enddate>197811</enddate><creator>Pratt, J.H.</creator><creator>Parkinson, C.A.</creator><creator>Luft, F.C.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>197811</creationdate><title>A new approach to the difficult assessment of aldosterone secretion in anephric patients</title><author>Pratt, J.H. ; Parkinson, C.A. ; Luft, F.C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c356t-b032efedec8173bdbe999ccbdd6d9f2f69ec3f07e7121d16726dcf88f0d30cf13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1978</creationdate><topic>Adolescent</topic><topic>Adrenocorticotropic Hormone</topic><topic>Adult</topic><topic>Aldosterone - analogs & derivatives</topic><topic>Aldosterone - blood</topic><topic>Female</topic><topic>Glucuronates - blood</topic><topic>Humans</topic><topic>Male</topic><topic>Nephrectomy</topic><topic>Potassium - blood</topic><topic>Radioimmunoassay - methods</topic><topic>Renal Dialysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pratt, J.H.</creatorcontrib><creatorcontrib>Parkinson, C.A.</creatorcontrib><creatorcontrib>Luft, F.C.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Steroids</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pratt, J.H.</au><au>Parkinson, C.A.</au><au>Luft, F.C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A new approach to the difficult assessment of aldosterone secretion in anephric patients</atitle><jtitle>Steroids</jtitle><addtitle>Steroids</addtitle><date>1978-11</date><risdate>1978</risdate><volume>32</volume><issue>4</issue><spage>487</spage><epage>498</epage><pages>487-498</pages><issn>0039-128X</issn><eissn>1878-5867</eissn><abstract>A new method for the assessment of endogenous formation of aldosterone in anephric patients is described. (1, 2-
3H) aldosterone was administered i.v. to patients 1–2 days before hemodialysis, and then the specific activity (SA) of tetrahydroaldosterone glucosiduronate, the major aldosterone metabolite, was measured in the dialysate using a specific radioimmunoassay. The aldosterone secretion rate was determined from the extent of isotope dilution by endogenous metabolite.
Aldosterone secretion rates measured in 10 patients were for the most part low. The secretion rate determined in blood from the aldosterone metabolic clearance rate and plasma aldosterone concentration closely approximate secretion rate values obtained by the isotope dilution method in 3 of 4 patients.
In 2 patients in whom ACTH was administered chronically, radio-labeled aldosterone was administered at the start of the study and then the day to day aldosterone secretory response to ACTH was determined from the SA of tetrahydroaldosterone in blood. Aldosterone secretion continuously increased for as long as ACTH was administered</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>214904</pmid><doi>10.1016/0039-128X(78)90060-0</doi><tpages>12</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0039-128X |
| ispartof | Steroids, 1978-11, Vol.32 (4), p.487-498 |
| issn | 0039-128X 1878-5867 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adolescent Adrenocorticotropic Hormone Adult Aldosterone - analogs & derivatives Aldosterone - blood Female Glucuronates - blood Humans Male Nephrectomy Potassium - blood Radioimmunoassay - methods Renal Dialysis |
| title | A new approach to the difficult assessment of aldosterone secretion in anephric patients |
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