The Dopamine Hypothesis: An Overview of Studies With Schizophrenic Patients
For the past decade, the dopamine hypothesis of schizophrenia has been the predominant biochemical theory of schizophrenia. Despite the extensive study of tissue samples obtained from schizophrenics, indirect pharmacological evidence still provides the major support for the hypothesis. Direct suppor...
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| Veröffentlicht in: | Schizophrenia bulletin 1982, Vol.8 (3), p.438-469 |
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| container_title | Schizophrenia bulletin |
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| creator | Haracz, John L |
| description | For the past decade, the dopamine hypothesis of schizophrenia has been the predominant biochemical theory of schizophrenia. Despite the extensive study of tissue samples obtained from schizophrenics, indirect pharmacological evidence still provides the major support for the hypothesis. Direct support is either uncompelling or has not been widely replicated. The dopamine hypothesis is limited in theoretical scope and in the range of schizophrenic patients to which it applies. No comprehensive biological scheme has yet been proposed to draw together the genetic, environmental, and clinical features of schizophrenia. Recent refinements of the dopamine hypothesis may aid in the delineation of biologically homogeneous subgroups. Positive symptoms (e.g., hallucinations, delusions) and negative symptomatology (e.g., affective flattening, social withdrawal) may result from different pathophysiological processes. Schizophrenia research might benefit from an increased attention to neurophysiological adaptations. |
| doi_str_mv | 10.1093/schbul/8.3.438 |
| format | Article |
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Despite the extensive study of tissue samples obtained from schizophrenics, indirect pharmacological evidence still provides the major support for the hypothesis. Direct support is either uncompelling or has not been widely replicated. The dopamine hypothesis is limited in theoretical scope and in the range of schizophrenic patients to which it applies. No comprehensive biological scheme has yet been proposed to draw together the genetic, environmental, and clinical features of schizophrenia. Recent refinements of the dopamine hypothesis may aid in the delineation of biologically homogeneous subgroups. Positive symptoms (e.g., hallucinations, delusions) and negative symptomatology (e.g., affective flattening, social withdrawal) may result from different pathophysiological processes. Schizophrenia research might benefit from an increased attention to neurophysiological adaptations.</description><subject>Adenylyl Cyclases - metabolism</subject><subject>Biochemistry</subject><subject>Brain - enzymology</subject><subject>Catechol O-Methyltransferase - metabolism</subject><subject>Dextroamphetamine - therapeutic use</subject><subject>Dopa Decarboxylase - metabolism</subject><subject>Dopamine</subject><subject>Dopamine - metabolism</subject><subject>Dopamine beta-Hydroxylase - metabolism</subject><subject>Etiology</subject><subject>Homovanillic Acid - metabolism</subject><subject>Human</subject><subject>Humans</subject><subject>Levodopa - therapeutic use</subject><subject>Literature Review</subject><subject>Monoamine Oxidase - blood</subject><subject>Monoamine Oxidase Inhibitors - therapeutic use</subject><subject>Receptors, Dopamine - metabolism</subject><subject>Schizophrenia</subject><subject>Schizophrenia - drug therapy</subject><subject>Schizophrenia - enzymology</subject><subject>Synapses - enzymology</subject><subject>Theories</subject><subject>Tyrosine 3-Monooxygenase - metabolism</subject><issn>0586-7614</issn><issn>1745-1701</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1982</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkEFr3DAQRkVoSDdpr7kVRA85BLzRSLIs9xaStCkJpJCUHoUsj7GC13YlOWXz66uySw49DcP35mN4hJwCWwOrxUV0fbMMF3ot1lLoA7KCSpYFVAzekRUrtSoqBfI9OY7xmTGQteJH5EgBrzTTK3L31CO9nma78SPS2-08pR6jj1_o5UgfXjC8ePxDp44-pqX1GOkvn3r66Hr_Os19wNE7-sMmj2OKH8hhZ4eIH_fzhPz8evN0dVvcP3z7fnV5X1hR81SoUmso0YqWgdKsVE4z1A1j0nZ5bWXjeFPbulTAgEtelS1HgLrpuqZUVSdOyNmudw7T7wVjMhsfHQ6DHXFaoqkkV1pyncHP_4HP0xLG_JvJToRgACpD6x3kwhRjwM7MwW9s2Bpg5p9is1NstBEmK84Hn_atS7PB9g3fO835-S63szVz3DobkncDRreELCyZ-Nq8lf0FgZuGYw</recordid><startdate>1982</startdate><enddate>1982</enddate><creator>Haracz, John L</creator><general>National Institute of Mental Health</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7RZ</scope><scope>PSYQQ</scope><scope>7X8</scope></search><sort><creationdate>1982</creationdate><title>The Dopamine Hypothesis: An Overview of Studies With Schizophrenic Patients</title><author>Haracz, John L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a392t-658815ea3d0168056c80e8b004af805d4bc2b9a95610124275d2e119bffb567f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1982</creationdate><topic>Adenylyl Cyclases - metabolism</topic><topic>Biochemistry</topic><topic>Brain - enzymology</topic><topic>Catechol O-Methyltransferase - metabolism</topic><topic>Dextroamphetamine - therapeutic use</topic><topic>Dopa Decarboxylase - metabolism</topic><topic>Dopamine</topic><topic>Dopamine - metabolism</topic><topic>Dopamine beta-Hydroxylase - metabolism</topic><topic>Etiology</topic><topic>Homovanillic Acid - metabolism</topic><topic>Human</topic><topic>Humans</topic><topic>Levodopa - therapeutic use</topic><topic>Literature Review</topic><topic>Monoamine Oxidase - blood</topic><topic>Monoamine Oxidase Inhibitors - therapeutic use</topic><topic>Receptors, Dopamine - metabolism</topic><topic>Schizophrenia</topic><topic>Schizophrenia - drug therapy</topic><topic>Schizophrenia - enzymology</topic><topic>Synapses - enzymology</topic><topic>Theories</topic><topic>Tyrosine 3-Monooxygenase - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Haracz, John L</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>APA PsycArticles®</collection><collection>ProQuest One Psychology</collection><collection>MEDLINE - Academic</collection><jtitle>Schizophrenia bulletin</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Haracz, John L</au><au>Keith, Samuel J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Dopamine Hypothesis: An Overview of Studies With Schizophrenic Patients</atitle><jtitle>Schizophrenia bulletin</jtitle><addtitle>Schizophr Bull</addtitle><date>1982</date><risdate>1982</risdate><volume>8</volume><issue>3</issue><spage>438</spage><epage>469</epage><pages>438-469</pages><issn>0586-7614</issn><eissn>1745-1701</eissn><abstract>For the past decade, the dopamine hypothesis of schizophrenia has been the predominant biochemical theory of schizophrenia. Despite the extensive study of tissue samples obtained from schizophrenics, indirect pharmacological evidence still provides the major support for the hypothesis. Direct support is either uncompelling or has not been widely replicated. The dopamine hypothesis is limited in theoretical scope and in the range of schizophrenic patients to which it applies. No comprehensive biological scheme has yet been proposed to draw together the genetic, environmental, and clinical features of schizophrenia. Recent refinements of the dopamine hypothesis may aid in the delineation of biologically homogeneous subgroups. Positive symptoms (e.g., hallucinations, delusions) and negative symptomatology (e.g., affective flattening, social withdrawal) may result from different pathophysiological processes. Schizophrenia research might benefit from an increased attention to neurophysiological adaptations.</abstract><cop>United States</cop><pub>National Institute of Mental Health</pub><pmid>6127808</pmid><doi>10.1093/schbul/8.3.438</doi><tpages>32</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Schizophrenia bulletin, 1982, Vol.8 (3), p.438-469 |
| issn | 0586-7614 1745-1701 |
| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Oxford University Press Journals Digital Archive Legacy; EBSCOhost APA PsycARTICLES; Alma/SFX Local Collection |
| subjects | Adenylyl Cyclases - metabolism Biochemistry Brain - enzymology Catechol O-Methyltransferase - metabolism Dextroamphetamine - therapeutic use Dopa Decarboxylase - metabolism Dopamine Dopamine - metabolism Dopamine beta-Hydroxylase - metabolism Etiology Homovanillic Acid - metabolism Human Humans Levodopa - therapeutic use Literature Review Monoamine Oxidase - blood Monoamine Oxidase Inhibitors - therapeutic use Receptors, Dopamine - metabolism Schizophrenia Schizophrenia - drug therapy Schizophrenia - enzymology Synapses - enzymology Theories Tyrosine 3-Monooxygenase - metabolism |
| title | The Dopamine Hypothesis: An Overview of Studies With Schizophrenic Patients |
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