Differential in vitro effects of etretinate and retinoic acid on the PHA and Con a induced lymphocyte transformation, suppressor cell induction and leukocyte migration inhibitory factor (LMIF) production
The in vitro influence of two retinoids, etretinate and retinoic acid, on the human lymphocyte transformation, on the induction of suppressor cells and on leukocyte migration inhibitory factor (LMIF) production were investigated. Nontoxic concentration of retinoic acid increased significantly the PH...
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| Veröffentlicht in: | International journal of immunopharmacology 1982, Vol.4 (5), p.437-443 |
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| container_end_page | 443 |
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| container_issue | 5 |
| container_start_page | 437 |
| container_title | International journal of immunopharmacology |
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| creator | Soppi, E. Tertti, R. Soppi, A.-M. Toivanen, A. Jansén, C.T. |
| description | The
in vitro influence of two retinoids, etretinate and retinoic acid, on the human lymphocyte transformation, on the induction of suppressor cells and on leukocyte migration inhibitory factor (LMIF) production were investigated. Nontoxic concentration of retinoic acid increased significantly the PHA response to suboptimal mitogen concentrations, but had no effect on the Con A response; it also abolished the PHA induced LMIF production. In corresponding assays etretinate was without effect. Etretinate augmented the PHA induced suppressor cell activity, while retinoic acid was ineffective. No effect was observed on Con A induced suppressor cells by either retinoid. The findings extend the information about the immunomodulatory effects of retinoids and demonstrate that retinoic acid and etretinate have different effects on PHA and Con A induced immune responses. The mode of action of retinoids is discussed. |
| doi_str_mv | 10.1016/0192-0561(82)90018-2 |
| format | Article |
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in vitro influence of two retinoids, etretinate and retinoic acid, on the human lymphocyte transformation, on the induction of suppressor cells and on leukocyte migration inhibitory factor (LMIF) production were investigated. Nontoxic concentration of retinoic acid increased significantly the PHA response to suboptimal mitogen concentrations, but had no effect on the Con A response; it also abolished the PHA induced LMIF production. In corresponding assays etretinate was without effect. Etretinate augmented the PHA induced suppressor cell activity, while retinoic acid was ineffective. No effect was observed on Con A induced suppressor cells by either retinoid. The findings extend the information about the immunomodulatory effects of retinoids and demonstrate that retinoic acid and etretinate have different effects on PHA and Con A induced immune responses. The mode of action of retinoids is discussed.</description><identifier>ISSN: 0192-0561</identifier><identifier>EISSN: 1879-3495</identifier><identifier>DOI: 10.1016/0192-0561(82)90018-2</identifier><identifier>PMID: 6215368</identifier><language>eng</language><publisher>England: Elsevier Science</publisher><subject>Concanavalin A - pharmacology ; Etretinate - pharmacology ; Humans ; In Vitro Techniques ; Leukocyte Migration-Inhibitory Factors - biosynthesis ; Lymphocyte Activation - drug effects ; Lymphocytes - drug effects ; Lymphocytes - immunology ; Lymphokines - biosynthesis ; Phytohemagglutinins - pharmacology ; T-Lymphocytes, Regulatory - drug effects ; Tretinoin - analogs & derivatives ; Tretinoin - pharmacology</subject><ispartof>International journal of immunopharmacology, 1982, Vol.4 (5), p.437-443</ispartof><rights>1982</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c303t-a90b7355ff71d325185e70d0c1a3d45eca89d54e5484f3015675acbd1b35ea5c3</citedby><cites>FETCH-LOGICAL-c303t-a90b7355ff71d325185e70d0c1a3d45eca89d54e5484f3015675acbd1b35ea5c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,4009,27902,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6215368$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Soppi, E.</creatorcontrib><creatorcontrib>Tertti, R.</creatorcontrib><creatorcontrib>Soppi, A.-M.</creatorcontrib><creatorcontrib>Toivanen, A.</creatorcontrib><creatorcontrib>Jansén, C.T.</creatorcontrib><title>Differential in vitro effects of etretinate and retinoic acid on the PHA and Con a induced lymphocyte transformation, suppressor cell induction and leukocyte migration inhibitory factor (LMIF) production</title><title>International journal of immunopharmacology</title><addtitle>Int J Immunopharmacol</addtitle><description>The
in vitro influence of two retinoids, etretinate and retinoic acid, on the human lymphocyte transformation, on the induction of suppressor cells and on leukocyte migration inhibitory factor (LMIF) production were investigated. Nontoxic concentration of retinoic acid increased significantly the PHA response to suboptimal mitogen concentrations, but had no effect on the Con A response; it also abolished the PHA induced LMIF production. In corresponding assays etretinate was without effect. Etretinate augmented the PHA induced suppressor cell activity, while retinoic acid was ineffective. No effect was observed on Con A induced suppressor cells by either retinoid. The findings extend the information about the immunomodulatory effects of retinoids and demonstrate that retinoic acid and etretinate have different effects on PHA and Con A induced immune responses. The mode of action of retinoids is discussed.</description><subject>Concanavalin A - pharmacology</subject><subject>Etretinate - pharmacology</subject><subject>Humans</subject><subject>In Vitro Techniques</subject><subject>Leukocyte Migration-Inhibitory Factors - biosynthesis</subject><subject>Lymphocyte Activation - drug effects</subject><subject>Lymphocytes - drug effects</subject><subject>Lymphocytes - immunology</subject><subject>Lymphokines - biosynthesis</subject><subject>Phytohemagglutinins - pharmacology</subject><subject>T-Lymphocytes, Regulatory - drug effects</subject><subject>Tretinoin - analogs & derivatives</subject><subject>Tretinoin - pharmacology</subject><issn>0192-0561</issn><issn>1879-3495</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1982</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkctu1DAUhi0EKtPCG4DkFWolAr7EuWyQqqGllQbBAtaWYx8zhiQebKfSPCMvhZOMuoSVdfxfjuwPoVeUvKOEVu8JbVlBREUvG3bVEkKbgj1BG9rUbcHLVjxFm0fLc3Qe409CiKAVO0NnFaOCV80G_fnorIUAY3Kqx27EDy4FjyFf6hSxtxhSgORGlQCr0eBl8E5jpZ3BfsRpD_jr3fUibvOscouZNBjcH4fD3utjTqagxmh9GFRyfnyL43Q4BIjRB6yh79fILC01PUy_1tzgfoQlkh1717nkwxFbpfOJL3ef72-v8CH4U_YFemZVH-Hl6bxA329vvm3vit2XT_fb612hOeGpUC3pai6EtTU1nAnaCKiJIZoqbkoBWjWtESWIsiktJ1RUtVC6M7TjApTQ_AK9WXvz6t8TxCQHF-dnqBH8FGVdsqohpP6vkXJRVoTxbCxXow4-xgBWHoIbVDhKSuQMW84k5UxSNkwusCXLsden_qkbwDyGTnSz_mHVIf_Gg4Mgo3YwZjYuZLzSePfvBX8BTQS9Cg</recordid><startdate>1982</startdate><enddate>1982</enddate><creator>Soppi, E.</creator><creator>Tertti, R.</creator><creator>Soppi, A.-M.</creator><creator>Toivanen, A.</creator><creator>Jansén, C.T.</creator><general>Elsevier Science</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>1982</creationdate><title>Differential in vitro effects of etretinate and retinoic acid on the PHA and Con a induced lymphocyte transformation, suppressor cell induction and leukocyte migration inhibitory factor (LMIF) production</title><author>Soppi, E. ; Tertti, R. ; Soppi, A.-M. ; Toivanen, A. ; Jansén, C.T.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c303t-a90b7355ff71d325185e70d0c1a3d45eca89d54e5484f3015675acbd1b35ea5c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1982</creationdate><topic>Concanavalin A - pharmacology</topic><topic>Etretinate - pharmacology</topic><topic>Humans</topic><topic>In Vitro Techniques</topic><topic>Leukocyte Migration-Inhibitory Factors - biosynthesis</topic><topic>Lymphocyte Activation - drug effects</topic><topic>Lymphocytes - drug effects</topic><topic>Lymphocytes - immunology</topic><topic>Lymphokines - biosynthesis</topic><topic>Phytohemagglutinins - pharmacology</topic><topic>T-Lymphocytes, Regulatory - drug effects</topic><topic>Tretinoin - analogs & derivatives</topic><topic>Tretinoin - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Soppi, E.</creatorcontrib><creatorcontrib>Tertti, R.</creatorcontrib><creatorcontrib>Soppi, A.-M.</creatorcontrib><creatorcontrib>Toivanen, A.</creatorcontrib><creatorcontrib>Jansén, C.T.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of immunopharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Soppi, E.</au><au>Tertti, R.</au><au>Soppi, A.-M.</au><au>Toivanen, A.</au><au>Jansén, C.T.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Differential in vitro effects of etretinate and retinoic acid on the PHA and Con a induced lymphocyte transformation, suppressor cell induction and leukocyte migration inhibitory factor (LMIF) production</atitle><jtitle>International journal of immunopharmacology</jtitle><addtitle>Int J Immunopharmacol</addtitle><date>1982</date><risdate>1982</risdate><volume>4</volume><issue>5</issue><spage>437</spage><epage>443</epage><pages>437-443</pages><issn>0192-0561</issn><eissn>1879-3495</eissn><abstract>The
in vitro influence of two retinoids, etretinate and retinoic acid, on the human lymphocyte transformation, on the induction of suppressor cells and on leukocyte migration inhibitory factor (LMIF) production were investigated. Nontoxic concentration of retinoic acid increased significantly the PHA response to suboptimal mitogen concentrations, but had no effect on the Con A response; it also abolished the PHA induced LMIF production. In corresponding assays etretinate was without effect. Etretinate augmented the PHA induced suppressor cell activity, while retinoic acid was ineffective. No effect was observed on Con A induced suppressor cells by either retinoid. The findings extend the information about the immunomodulatory effects of retinoids and demonstrate that retinoic acid and etretinate have different effects on PHA and Con A induced immune responses. The mode of action of retinoids is discussed.</abstract><cop>England</cop><pub>Elsevier Science</pub><pmid>6215368</pmid><doi>10.1016/0192-0561(82)90018-2</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0192-0561 |
| ispartof | International journal of immunopharmacology, 1982, Vol.4 (5), p.437-443 |
| issn | 0192-0561 1879-3495 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_74268007 |
| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Concanavalin A - pharmacology Etretinate - pharmacology Humans In Vitro Techniques Leukocyte Migration-Inhibitory Factors - biosynthesis Lymphocyte Activation - drug effects Lymphocytes - drug effects Lymphocytes - immunology Lymphokines - biosynthesis Phytohemagglutinins - pharmacology T-Lymphocytes, Regulatory - drug effects Tretinoin - analogs & derivatives Tretinoin - pharmacology |
| title | Differential in vitro effects of etretinate and retinoic acid on the PHA and Con a induced lymphocyte transformation, suppressor cell induction and leukocyte migration inhibitory factor (LMIF) production |
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