IgE-mediated 14C-serotonin release from rat mast cells modulated by morphine and endorphins

The formaldehyde method was used to examine the interaction of PGE 1 with morphine, β-endorphin and Met-enkephalin on rat mast cells by their effects on IgE-mediated 14C-serotonin release. PGE 1 (2×10 −8−2×10 −5 M) caused a dose-related inhibition of the mediator release 1 min after an antigen chall...

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Veröffentlicht in:	Life sciences (1973) 1982-08, Vol.31 (5), p.471-478
Hauptverfasser:	Yamasaki, Yoshihide, Shimamura, Osamu, Kizu, Akira, Nakagawa, Masao, Ijichi, Hamao
Format:	Artikel
Sprache:	eng
Schlagworte:	Alprostadil Animals Dose-Response Relationship, Drug Endorphins - pharmacology Immunoglobulin E - metabolism Kinetics Male Mast Cells - metabolism Morphine - pharmacology Naloxone - pharmacology Prostaglandins E - pharmacology Rats Rats, Inbred Strains Serotonin - metabolism
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