Tautomerism of Singly Protonated Chloroquine and Quinacrine

Differential absorptiometric pH titrations of the antimalarials chloroquine and quinacrine, employing the respective uncharged species at pH12.5 in the reference cell, show that protolytic dissociation from the heterocyclic ring nitrogen atoms occurs over pH6–12. This finding indicates that the sing...

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Veröffentlicht in:	Journal of pharmaceutical sciences 1978-12, Vol.67 (12), p.1770-1772
Hauptverfasser:	Rosenberg, Leonard S., Schulman, Stephen G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antimalarials-chloroquine and quinacrine Antimalarials—chloroquine and quinacrine, protolytic dissociation, spectrophotometric evaluation Chloroquine - analysis Chloroquine-protolytic dissociation Chloroquine—protolytic dissociation, spectrophotometric evaluation Dissociation Dissociation, protolytic—chloroquine and quinacrine, spectrophotometric evaluation Hydrogen-Ion Concentration Kinetics protolytic dissociation protolytic dissociation of chloroquine and quinacrine protolytic-chloroquine and quinacrine Quinacrine - analysis Quinacrine-protolytic dissociation Quinacrine—protolytic dissociation, spectrophotometric evaluation spectrophotometric evaluation Spectrophotometry Spectrophotometry, Ultraviolet Spectrophotometry-evaluation Spectrophotometry—evaluation, protolytic dissociation of chloroquine and quinacrine Stereoisomerism
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