Alteration of diabetes and interferon induction by the diabetogenic strain of encephalomyocarditis virus through cell passage
The diabetogenic strain of encephalomyocarditis virus (D virus) was propagated in several continuous cell lines. Each virus stock was tested for its ability to produce diabetes in mice and induce L-cell interferon (IFN-beta). The effect of insulin on virus replication and IFN-beta induction was also...
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| Veröffentlicht in: | Journal of interferon research 1982, Vol.2 (3), p.371-376 |
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| container_end_page | 376 |
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| container_title | Journal of interferon research |
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| creator | Giron, D J Patterson, R R Lyons, S P |
| description | The diabetogenic strain of encephalomyocarditis virus (D virus) was propagated in several continuous cell lines. Each virus stock was tested for its ability to produce diabetes in mice and induce L-cell interferon (IFN-beta). The effect of insulin on virus replication and IFN-beta induction was also determined. It was found that the severity of the diabetes and the amount of IFN-beta produced was dependent on the cell line used for virus propagation. Virus synthesis was augmented and IFN-beta production was altered in insulin-treated cell cultures. It is concluded that D virus either consists of more than one virus or that its diabetes and IFN-beta inducing characteristics are unstable. |
| doi_str_mv | 10.1089/jir.1982.2.371 |
| format | Article |
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Each virus stock was tested for its ability to produce diabetes in mice and induce L-cell interferon (IFN-beta). The effect of insulin on virus replication and IFN-beta induction was also determined. It was found that the severity of the diabetes and the amount of IFN-beta produced was dependent on the cell line used for virus propagation. Virus synthesis was augmented and IFN-beta production was altered in insulin-treated cell cultures. It is concluded that D virus either consists of more than one virus or that its diabetes and IFN-beta inducing characteristics are unstable.</description><identifier>ISSN: 0197-8357</identifier><identifier>DOI: 10.1089/jir.1982.2.371</identifier><identifier>PMID: 6290577</identifier><language>eng</language><publisher>United States</publisher><subject>Animals ; Cell Line ; Cricetinae ; Diabetes Mellitus, Experimental - microbiology ; encephalomyocarditis virus ; Encephalomyocarditis virus - physiology ; Enterovirus Infections - immunology ; Enterovirus Infections - microbiology ; Humans ; Insulin - pharmacology ; Interferon Type I - biosynthesis ; Male ; Mice ; Virus Cultivation ; Virus Replication - drug effects</subject><ispartof>Journal of interferon research, 1982, Vol.2 (3), p.371-376</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c321t-1fbbed939879708dc165811ce6393ca80ea1c0974eda18583ef16cc2b2a143f3</citedby><cites>FETCH-LOGICAL-c321t-1fbbed939879708dc165811ce6393ca80ea1c0974eda18583ef16cc2b2a143f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,3029,4010,27900,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6290577$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Giron, D J</creatorcontrib><creatorcontrib>Patterson, R R</creatorcontrib><creatorcontrib>Lyons, S P</creatorcontrib><title>Alteration of diabetes and interferon induction by the diabetogenic strain of encephalomyocarditis virus through cell passage</title><title>Journal of interferon research</title><addtitle>J Interferon Res</addtitle><description>The diabetogenic strain of encephalomyocarditis virus (D virus) was propagated in several continuous cell lines. Each virus stock was tested for its ability to produce diabetes in mice and induce L-cell interferon (IFN-beta). The effect of insulin on virus replication and IFN-beta induction was also determined. It was found that the severity of the diabetes and the amount of IFN-beta produced was dependent on the cell line used for virus propagation. Virus synthesis was augmented and IFN-beta production was altered in insulin-treated cell cultures. It is concluded that D virus either consists of more than one virus or that its diabetes and IFN-beta inducing characteristics are unstable.</description><subject>Animals</subject><subject>Cell Line</subject><subject>Cricetinae</subject><subject>Diabetes Mellitus, Experimental - microbiology</subject><subject>encephalomyocarditis virus</subject><subject>Encephalomyocarditis virus - physiology</subject><subject>Enterovirus Infections - immunology</subject><subject>Enterovirus Infections - microbiology</subject><subject>Humans</subject><subject>Insulin - pharmacology</subject><subject>Interferon Type I - biosynthesis</subject><subject>Male</subject><subject>Mice</subject><subject>Virus Cultivation</subject><subject>Virus Replication - drug effects</subject><issn>0197-8357</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1982</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkTtPwzAUhT2ASimsbEie2Bp87Sa2x6riJVVi6W45zk3rKo2LnSB14L-TPsTKdIfznaMrfYQ8AMuAKf289TEDrXjGMyHhiowZaDlVIpc35DalLWNFLjmMyKjgmuVSjsnPvOkw2s6HloaaVt6W2GGitq2ob4eoxjhEvq16d4LKA-02eAHDGlvvaOqi9ac-tg73G9uE3SE4Gyvf-US_fezT0IqhX2-ow6ahe5uSXeMdua5tk_D-cidk9fqyWrxPl59vH4v5cuoEh24KdVlipYVWUkumKgdFrgAcFkILZxVDC45pOcPKgsqVwBoK53jJLcxELSbk6Ty7j-Grx9SZnU_HP2yLoU9GznjBBRf_giDyXGqtBjA7gy6GlCLWZh_9zsaDAWaOLszgwhxdGG4GF0Ph8bLclzus_vCLCPELcX-Kaw</recordid><startdate>1982</startdate><enddate>1982</enddate><creator>Giron, D J</creator><creator>Patterson, R R</creator><creator>Lyons, S P</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>1982</creationdate><title>Alteration of diabetes and interferon induction by the diabetogenic strain of encephalomyocarditis virus through cell passage</title><author>Giron, D J ; Patterson, R R ; Lyons, S P</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c321t-1fbbed939879708dc165811ce6393ca80ea1c0974eda18583ef16cc2b2a143f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1982</creationdate><topic>Animals</topic><topic>Cell Line</topic><topic>Cricetinae</topic><topic>Diabetes Mellitus, Experimental - microbiology</topic><topic>encephalomyocarditis virus</topic><topic>Encephalomyocarditis virus - physiology</topic><topic>Enterovirus Infections - immunology</topic><topic>Enterovirus Infections - microbiology</topic><topic>Humans</topic><topic>Insulin - pharmacology</topic><topic>Interferon Type I - biosynthesis</topic><topic>Male</topic><topic>Mice</topic><topic>Virus Cultivation</topic><topic>Virus Replication - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Giron, D J</creatorcontrib><creatorcontrib>Patterson, R R</creatorcontrib><creatorcontrib>Lyons, S P</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of interferon research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Giron, D J</au><au>Patterson, R R</au><au>Lyons, S P</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Alteration of diabetes and interferon induction by the diabetogenic strain of encephalomyocarditis virus through cell passage</atitle><jtitle>Journal of interferon research</jtitle><addtitle>J Interferon Res</addtitle><date>1982</date><risdate>1982</risdate><volume>2</volume><issue>3</issue><spage>371</spage><epage>376</epage><pages>371-376</pages><issn>0197-8357</issn><abstract>The diabetogenic strain of encephalomyocarditis virus (D virus) was propagated in several continuous cell lines. Each virus stock was tested for its ability to produce diabetes in mice and induce L-cell interferon (IFN-beta). The effect of insulin on virus replication and IFN-beta induction was also determined. It was found that the severity of the diabetes and the amount of IFN-beta produced was dependent on the cell line used for virus propagation. Virus synthesis was augmented and IFN-beta production was altered in insulin-treated cell cultures. It is concluded that D virus either consists of more than one virus or that its diabetes and IFN-beta inducing characteristics are unstable.</abstract><cop>United States</cop><pmid>6290577</pmid><doi>10.1089/jir.1982.2.371</doi><tpages>6</tpages></addata></record> |
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| identifier | ISSN: 0197-8357 |
| ispartof | Journal of interferon research, 1982, Vol.2 (3), p.371-376 |
| issn | 0197-8357 |
| language | eng |
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| source | Mary Ann Liebert Online Subscription; MEDLINE |
| subjects | Animals Cell Line Cricetinae Diabetes Mellitus, Experimental - microbiology encephalomyocarditis virus Encephalomyocarditis virus - physiology Enterovirus Infections - immunology Enterovirus Infections - microbiology Humans Insulin - pharmacology Interferon Type I - biosynthesis Male Mice Virus Cultivation Virus Replication - drug effects |
| title | Alteration of diabetes and interferon induction by the diabetogenic strain of encephalomyocarditis virus through cell passage |
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