4-(6-Methoxy-2-naphthyl)butan-2-one and related analogs, a novel structural class of antiinflammatory compounds
A series of compounds related to 4-(6-methoxy-2-naphthyl)butan-2-one has been prepared and tested for antiinflammatory activity by the cotton pellet granuloma method. Compounds possessing a small lipophilic group such as methoxyl, methyl, or chloro in the 6 position in conjunction with a butan-2-one...
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| Veröffentlicht in: | Journal of medicinal chemistry 1978-12, Vol.21 (12), p.1260-1264 |
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| container_end_page | 1264 |
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| container_issue | 12 |
| container_start_page | 1260 |
| container_title | Journal of medicinal chemistry |
| container_volume | 21 |
| creator | Goudie, Alexander C Gaster, Laramie M Lake, Antony W Rose, Carl J Freeman, Patricia C Hughes, Bryn O Miller, David |
| description | A series of compounds related to 4-(6-methoxy-2-naphthyl)butan-2-one has been prepared and tested for antiinflammatory activity by the cotton pellet granuloma method. Compounds possessing a small lipophilic group such as methoxyl, methyl, or chloro in the 6 position in conjunction with a butan-2-one side chain in the 2 position of the naphthalene ring were most active. The indtroduction of a methyl group along the side chain was invariably deleterious. Good activity was generally retained by forming esters of a butan-2-ol side chain. |
| doi_str_mv | 10.1021/jm00210a016 |
| format | Article |
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Compounds possessing a small lipophilic group such as methoxyl, methyl, or chloro in the 6 position in conjunction with a butan-2-one side chain in the 2 position of the naphthalene ring were most active. The indtroduction of a methyl group along the side chain was invariably deleterious. 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| fulltext | fulltext |
| identifier | ISSN: 0022-2623 |
| ispartof | Journal of medicinal chemistry, 1978-12, Vol.21 (12), p.1260-1264 |
| issn | 0022-2623 1520-4804 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_74261559 |
| source | ACS Publications; MEDLINE |
| subjects | Animals Anti-Inflammatory Agents - chemical synthesis Female Gossypium Granuloma - etiology Granuloma - physiopathology Naphthalenes - chemical synthesis Naphthalenes - pharmacology Rats Structure-Activity Relationship |
| title | 4-(6-Methoxy-2-naphthyl)butan-2-one and related analogs, a novel structural class of antiinflammatory compounds |
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