High plasma norepinephrine levels in patients with major affective disorder
The authors found that patients with major affective disorder had higher levels of plasma norepinephrine and higher pulse rates (tachycardia) than healthy control subjects, but their blood pressures were normal. These measurements were similar in all three subgroups of patients with affective disord...
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| Veröffentlicht in: | The American journal of psychiatry 1982-10, Vol.139 (10), p.1315-1318 |
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| container_title | The American journal of psychiatry |
| container_volume | 139 |
| creator | Lake, C R Pickar, D Ziegler, M G Lipper, S Slater, S Murphy, D L |
| description | The authors found that patients with major affective disorder had higher
levels of plasma norepinephrine and higher pulse rates (tachycardia) than
healthy control subjects, but their blood pressures were normal. These
measurements were similar in all three subgroups of patients with affective
disorder--manic, bipolar depressed, and unipolar. Because norepinephrine is
the primary neurotransmitter of the sympathetic nervous system, these data
suggest sympathetic hyperactivity in the major affective disorders. This
conclusion is compatible with recent speculation based on the effect of
antidepressants on noradrenergic receptors and a failure of alpha-
receptors to downregulate normally in patients with major affective
disorder. |
| doi_str_mv | 10.1176/ajp.139.10.1315 |
| format | Article |
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levels of plasma norepinephrine and higher pulse rates (tachycardia) than
healthy control subjects, but their blood pressures were normal. These
measurements were similar in all three subgroups of patients with affective
disorder--manic, bipolar depressed, and unipolar. Because norepinephrine is
the primary neurotransmitter of the sympathetic nervous system, these data
suggest sympathetic hyperactivity in the major affective disorders. This
conclusion is compatible with recent speculation based on the effect of
antidepressants on noradrenergic receptors and a failure of alpha-
receptors to downregulate normally in patients with major affective
disorder.</description><identifier>ISSN: 0002-953X</identifier><identifier>EISSN: 1535-7228</identifier><identifier>DOI: 10.1176/ajp.139.10.1315</identifier><identifier>PMID: 6289682</identifier><language>eng</language><publisher>United States: American Psychiatric Publishing</publisher><subject>Adult ; Affective Disorders, Psychotic - blood ; Affective Disorders, Psychotic - physiopathology ; Aged ; Bipolar Disorder - blood ; Bipolar Disorder - physiopathology ; Blood Pressure ; Depressive Disorder - blood ; Depressive Disorder - physiopathology ; Humans ; Middle Aged ; Norepinephrine - blood ; Receptors, Adrenergic, alpha - physiology ; Tachycardia - physiopathology</subject><ispartof>The American journal of psychiatry, 1982-10, Vol.139 (10), p.1315-1318</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a357t-46ee9a2df0065d1f6598ee3ea4a2c72ccaffbdddb7e1b2a23e7662604ea16fe53</citedby><cites>FETCH-LOGICAL-a357t-46ee9a2df0065d1f6598ee3ea4a2c72ccaffbdddb7e1b2a23e7662604ea16fe53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://psychiatryonline.org/doi/epdf/10.1176/ajp.139.10.1315$$EPDF$$P50$$Gappi$$H</linktopdf><linktohtml>$$Uhttps://psychiatryonline.org/doi/full/10.1176/ajp.139.10.1315$$EHTML$$P50$$Gappi$$H</linktohtml><link.rule.ids>315,781,785,2860,21631,27871,27926,27927,77793,77794</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6289682$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lake, C R</creatorcontrib><creatorcontrib>Pickar, D</creatorcontrib><creatorcontrib>Ziegler, M G</creatorcontrib><creatorcontrib>Lipper, S</creatorcontrib><creatorcontrib>Slater, S</creatorcontrib><creatorcontrib>Murphy, D L</creatorcontrib><title>High plasma norepinephrine levels in patients with major affective disorder</title><title>The American journal of psychiatry</title><addtitle>Am J Psychiatry</addtitle><description>The authors found that patients with major affective disorder had higher
levels of plasma norepinephrine and higher pulse rates (tachycardia) than
healthy control subjects, but their blood pressures were normal. These
measurements were similar in all three subgroups of patients with affective
disorder--manic, bipolar depressed, and unipolar. Because norepinephrine is
the primary neurotransmitter of the sympathetic nervous system, these data
suggest sympathetic hyperactivity in the major affective disorders. This
conclusion is compatible with recent speculation based on the effect of
antidepressants on noradrenergic receptors and a failure of alpha-
receptors to downregulate normally in patients with major affective
disorder.</description><subject>Adult</subject><subject>Affective Disorders, Psychotic - blood</subject><subject>Affective Disorders, Psychotic - physiopathology</subject><subject>Aged</subject><subject>Bipolar Disorder - blood</subject><subject>Bipolar Disorder - physiopathology</subject><subject>Blood Pressure</subject><subject>Depressive Disorder - blood</subject><subject>Depressive Disorder - physiopathology</subject><subject>Humans</subject><subject>Middle Aged</subject><subject>Norepinephrine - blood</subject><subject>Receptors, Adrenergic, alpha - physiology</subject><subject>Tachycardia - physiopathology</subject><issn>0002-953X</issn><issn>1535-7228</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1982</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>K30</sourceid><recordid>eNp1kM1LwzAYh4Moc07PnoSA4Mlu-WiS9ihDnTjwouCtpO1bl9GPmLQT_3szN0QELwk_3uf9JTwInVMypVTJmV7bKeXpdJs5FQdoTAUXkWIsOURjQgiLUsFfj9GJ9-sQCVdshEaSJalM2Bg9LszbCtta-0bjtnNgTQt25cKJa9hA7bFpsdW9gbb3-MP0K9zodeewriooerMBXBrfuRLcKTqqdO3hbH9P0Mvd7fN8ES2f7h_mN8tIc6H6KJYAqWZlRYgUJa2kSBMADjrWrFCsKEJzXpZlroDmTDMOSkomSQyaygoEn6CrXa913fsAvs8a4wuoa91CN_hMxUykLGUBvPwDrrvBteFvWZBFJFEqkYGa7ajCdd47qDLrTKPdZ0ZJtpWcBclhIf3OQXLYuNj3DnkD5Q-_txrm17u5ttb8evOfui-oXYcO</recordid><startdate>198210</startdate><enddate>198210</enddate><creator>Lake, C R</creator><creator>Pickar, D</creator><creator>Ziegler, M G</creator><creator>Lipper, S</creator><creator>Slater, S</creator><creator>Murphy, D L</creator><general>American Psychiatric Publishing</general><general>American Psychiatric Association</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>HAWNG</scope><scope>HBMBR</scope><scope>IBDFT</scope><scope>K30</scope><scope>PAAUG</scope><scope>PAWHS</scope><scope>PAWZZ</scope><scope>PAXOH</scope><scope>PBHAV</scope><scope>PBQSW</scope><scope>PBYQZ</scope><scope>PCIWU</scope><scope>PCMID</scope><scope>PCZJX</scope><scope>PDGRG</scope><scope>PDWWI</scope><scope>PETMR</scope><scope>PFVGT</scope><scope>PGXDX</scope><scope>PIHIL</scope><scope>PISVA</scope><scope>PJCTQ</scope><scope>PJTMS</scope><scope>PLCHJ</scope><scope>PMHAD</scope><scope>PNQDJ</scope><scope>POUND</scope><scope>PPLAD</scope><scope>PQAPC</scope><scope>PQCAN</scope><scope>PQCMW</scope><scope>PQEME</scope><scope>PQHKH</scope><scope>PQMID</scope><scope>PQNCT</scope><scope>PQNET</scope><scope>PQSCT</scope><scope>PQSET</scope><scope>PSVJG</scope><scope>PVMQY</scope><scope>PZGFC</scope><scope>7X8</scope></search><sort><creationdate>198210</creationdate><title>High plasma norepinephrine levels in patients with major affective disorder</title><author>Lake, C R ; Pickar, D ; Ziegler, M G ; Lipper, S ; Slater, S ; Murphy, D L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a357t-46ee9a2df0065d1f6598ee3ea4a2c72ccaffbdddb7e1b2a23e7662604ea16fe53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1982</creationdate><topic>Adult</topic><topic>Affective Disorders, Psychotic - blood</topic><topic>Affective Disorders, Psychotic - physiopathology</topic><topic>Aged</topic><topic>Bipolar Disorder - blood</topic><topic>Bipolar Disorder - physiopathology</topic><topic>Blood Pressure</topic><topic>Depressive Disorder - blood</topic><topic>Depressive Disorder - physiopathology</topic><topic>Humans</topic><topic>Middle Aged</topic><topic>Norepinephrine - blood</topic><topic>Receptors, Adrenergic, alpha - physiology</topic><topic>Tachycardia - physiopathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lake, C R</creatorcontrib><creatorcontrib>Pickar, D</creatorcontrib><creatorcontrib>Ziegler, M G</creatorcontrib><creatorcontrib>Lipper, S</creatorcontrib><creatorcontrib>Slater, S</creatorcontrib><creatorcontrib>Murphy, D L</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Periodicals Index Online Segment 13</collection><collection>Periodicals Index Online Segment 14</collection><collection>Periodicals Index Online Segment 27</collection><collection>Periodicals Index Online</collection><collection>Primary Sources Access—Foundation Edition (Plan E) - 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levels of plasma norepinephrine and higher pulse rates (tachycardia) than
healthy control subjects, but their blood pressures were normal. These
measurements were similar in all three subgroups of patients with affective
disorder--manic, bipolar depressed, and unipolar. Because norepinephrine is
the primary neurotransmitter of the sympathetic nervous system, these data
suggest sympathetic hyperactivity in the major affective disorders. This
conclusion is compatible with recent speculation based on the effect of
antidepressants on noradrenergic receptors and a failure of alpha-
receptors to downregulate normally in patients with major affective
disorder.</abstract><cop>United States</cop><pub>American Psychiatric Publishing</pub><pmid>6289682</pmid><doi>10.1176/ajp.139.10.1315</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0002-953X |
| ispartof | The American journal of psychiatry, 1982-10, Vol.139 (10), p.1315-1318 |
| issn | 0002-953X 1535-7228 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_74259292 |
| source | MEDLINE; Psychiatry Legacy Collection Online Journals 1844-1996; Periodicals Index Online |
| subjects | Adult Affective Disorders, Psychotic - blood Affective Disorders, Psychotic - physiopathology Aged Bipolar Disorder - blood Bipolar Disorder - physiopathology Blood Pressure Depressive Disorder - blood Depressive Disorder - physiopathology Humans Middle Aged Norepinephrine - blood Receptors, Adrenergic, alpha - physiology Tachycardia - physiopathology |
| title | High plasma norepinephrine levels in patients with major affective disorder |
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