Semisynthetic derivatives of glucagon: (des-His1)N epsilon-acetimidoglucagon and N alpha-Biotinyl-N epsilon-acetimidoglucagon

N epsilon-Acetimidoglucagon to be used for semisynthesis was prepared by reacting glucagon with methyl acetimidate hydrochloride at pH 10.2, favoring acetimidation of the sole epsilon-amino group. N epsilon-Acetimidoglucagon was isolated from the crude acetimidoglucagon mixture by anion-exchange chr...

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Veröffentlicht in:	Biochemistry (Easton) 1982-08, Vol.21 (18), p.4244-4251
Hauptverfasser:	Flanders, K C, Mar, D H, Folz, R J, England, R D, Coolican, S A, Harris, D E, Floyd, A D, Gurd, R S
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenylyl Cyclases - metabolism Animals Cell Membrane - metabolism Chemical Phenomena Chemistry Glucagon - analogs & derivatives Glucagon - chemical synthesis Glucagon - isolation & purification Glucagon - metabolism Imidoesters Indicators and Reagents Isoelectric Focusing Liver - metabolism Rats
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