3-Methylcholanthrene induces phenobarbital-induced cytochrome P-450 hemoprotein in fetal liver and not cytochrome P-448 hemoprotein induced in maternal liver of rats
The characteristic nature of the drug-metabolizing system in fetal liver microsomes of rats was investigated. The aminopyrine(AM)- and the hexobarbital (HB)-metabolizing activities in fetal liver microsomes of the 21st day of pregnancy were induced by the maternal administration of 3-methylcholanthr...
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| Veröffentlicht in: | Biochemical and biophysical research communications 1982-07, Vol.107 (1), p.6-11 |
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| container_title | Biochemical and biophysical research communications |
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| creator | Mizokami, K. Inoue, K. Sunouchi, M. Fujimori, K. Takanaka, A. Omori, Y. |
| description | The characteristic nature of the drug-metabolizing system in fetal liver microsomes of rats was investigated. The aminopyrine(AM)- and the hexobarbital (HB)-metabolizing activities in fetal liver microsomes of the 21st day of pregnancy were induced by the maternal administration of 3-methylcholanthrene (3-MC) once daily on the 18th and the 19th day of pregnancy, while they were inhibited in maternal liver microsomes. The inductions of the AM- and the HB-metabolizing enzymes in fetal liver microsomes of rat by the maternal administration of 3-MC occurred exclusively in fetal period and simultaneously hemoprotein like phenobarbital-induced type P-450 different from that in maternal liver microsomes was newly induced in fetal liver microsomes of rats. |
| doi_str_mv | 10.1016/0006-291X(82)91661-8 |
| format | Article |
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The aminopyrine(AM)- and the hexobarbital (HB)-metabolizing activities in fetal liver microsomes of the 21st day of pregnancy were induced by the maternal administration of 3-methylcholanthrene (3-MC) once daily on the 18th and the 19th day of pregnancy, while they were inhibited in maternal liver microsomes. 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The aminopyrine(AM)- and the hexobarbital (HB)-metabolizing activities in fetal liver microsomes of the 21st day of pregnancy were induced by the maternal administration of 3-methylcholanthrene (3-MC) once daily on the 18th and the 19th day of pregnancy, while they were inhibited in maternal liver microsomes. The inductions of the AM- and the HB-metabolizing enzymes in fetal liver microsomes of rat by the maternal administration of 3-MC occurred exclusively in fetal period and simultaneously hemoprotein like phenobarbital-induced type P-450 different from that in maternal liver microsomes was newly induced in fetal liver microsomes of rats.</description><subject>Animals</subject><subject>Cytochrome P-450 CYP1A2</subject><subject>Cytochrome P-450 Enzyme System - biosynthesis</subject><subject>Cytochromes - biosynthesis</subject><subject>Female</subject><subject>Fetus - metabolism</subject><subject>Hemeproteins - biosynthesis</subject><subject>Liver - embryology</subject><subject>Maternal-Fetal Exchange</subject><subject>Methylcholanthrene - pharmacology</subject><subject>Microsomes, Liver - drug effects</subject><subject>Microsomes, Liver - metabolism</subject><subject>Phenobarbital - pharmacology</subject><subject>Pregnancy</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><issn>0006-291X</issn><issn>1090-2104</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1982</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kUFrHCEcxaW0pJu03yAFTyU92OiMo86lEEKaFlKaQwq9iev8ZQwzulU3sB-o3zNuZ9lDDj0p_t_vqe8hdM7oZ0aZuKSUCtL07PeFaj71TAhG1Cu0YrSnpGGUv0aro-QtOs35kVLGuOhP0IlQqleiWaG_LfkBZdxNdoyTCWVMEAD7MGwtZLwZIcS1SWtfzESW0wHbXYl2THEGfE94R_EIc9ykWMCHimIHVY0n_wQJmzDgEMsLhqsXzGJct7MpkMIRjw4nU_I79MaZKcP7w3qGfn29ebj-Ru5-3n6_vrojtu1kIZ1iSlnbUjpY3rfKKRiY4K5dS-moU10DDDplTKeElNQZ10swXdM6KXlLeXuGPi6-9WV_tpCLnn22MNVkIG6zlrzpBGOqCvkitCnmnMDpTfKzSTvNqN63o_fR6330WjX6Xzt6j304-G_XMwxH6FBHnX9Z5lA_-eQh6Ww9hJqNT2CLHqL__wXPYtqhUA</recordid><startdate>19820716</startdate><enddate>19820716</enddate><creator>Mizokami, K.</creator><creator>Inoue, K.</creator><creator>Sunouchi, M.</creator><creator>Fujimori, K.</creator><creator>Takanaka, A.</creator><creator>Omori, Y.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19820716</creationdate><title>3-Methylcholanthrene induces phenobarbital-induced cytochrome P-450 hemoprotein in fetal liver and not cytochrome P-448 hemoprotein induced in maternal liver of rats</title><author>Mizokami, K. ; Inoue, K. ; Sunouchi, M. ; Fujimori, K. ; Takanaka, A. ; Omori, Y.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c357t-58188cc300dc4938f8ed164f3b77f0f852e1e58aa586770faf97ea523f7743043</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1982</creationdate><topic>Animals</topic><topic>Cytochrome P-450 CYP1A2</topic><topic>Cytochrome P-450 Enzyme System - biosynthesis</topic><topic>Cytochromes - biosynthesis</topic><topic>Female</topic><topic>Fetus - metabolism</topic><topic>Hemeproteins - biosynthesis</topic><topic>Liver - embryology</topic><topic>Maternal-Fetal Exchange</topic><topic>Methylcholanthrene - pharmacology</topic><topic>Microsomes, Liver - drug effects</topic><topic>Microsomes, Liver - metabolism</topic><topic>Phenobarbital - pharmacology</topic><topic>Pregnancy</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mizokami, K.</creatorcontrib><creatorcontrib>Inoue, K.</creatorcontrib><creatorcontrib>Sunouchi, M.</creatorcontrib><creatorcontrib>Fujimori, K.</creatorcontrib><creatorcontrib>Takanaka, A.</creatorcontrib><creatorcontrib>Omori, Y.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Biochemical and biophysical research communications</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mizokami, K.</au><au>Inoue, K.</au><au>Sunouchi, M.</au><au>Fujimori, K.</au><au>Takanaka, A.</au><au>Omori, Y.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>3-Methylcholanthrene induces phenobarbital-induced cytochrome P-450 hemoprotein in fetal liver and not cytochrome P-448 hemoprotein induced in maternal liver of rats</atitle><jtitle>Biochemical and biophysical research communications</jtitle><addtitle>Biochem Biophys Res Commun</addtitle><date>1982-07-16</date><risdate>1982</risdate><volume>107</volume><issue>1</issue><spage>6</spage><epage>11</epage><pages>6-11</pages><issn>0006-291X</issn><eissn>1090-2104</eissn><abstract>The characteristic nature of the drug-metabolizing system in fetal liver microsomes of rats was investigated. 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| fulltext | fulltext |
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| ispartof | Biochemical and biophysical research communications, 1982-07, Vol.107 (1), p.6-11 |
| issn | 0006-291X 1090-2104 |
| language | eng |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Animals Cytochrome P-450 CYP1A2 Cytochrome P-450 Enzyme System - biosynthesis Cytochromes - biosynthesis Female Fetus - metabolism Hemeproteins - biosynthesis Liver - embryology Maternal-Fetal Exchange Methylcholanthrene - pharmacology Microsomes, Liver - drug effects Microsomes, Liver - metabolism Phenobarbital - pharmacology Pregnancy Rats Rats, Inbred Strains |
| title | 3-Methylcholanthrene induces phenobarbital-induced cytochrome P-450 hemoprotein in fetal liver and not cytochrome P-448 hemoprotein induced in maternal liver of rats |
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