Prognostic significance of raised serum α‐fetoprotein levels in twin pregnancies
Maternal serum α‐fetoprotein (AFP) was measured during the second trimester in 219 twin pregnancies uncomplicated by neural‐tube defects (NTD) and in 11 twin pregnancies discordant for NTD. Serum AFP levels were recorded in multiples of the median value (MOM) calculated from normal singleton pregnan...
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| Veröffentlicht in: | BJOG : an international journal of obstetrics and gynaecology 1982-10, Vol.89 (10), p.817-820 |
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| container_title | BJOG : an international journal of obstetrics and gynaecology |
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| creator | GHOSH, A. WOO, J. S. K. RAWLINSON, H. A. FERGUSON‐SMITH, M. A. |
| description | Maternal serum α‐fetoprotein (AFP) was measured during the second trimester in 219 twin pregnancies uncomplicated by neural‐tube defects (NTD) and in 11 twin pregnancies discordant for NTD. Serum AFP levels were recorded in multiples of the median value (MOM) calculated from normal singleton pregnancies. Of the twin pregnancies uncomplicated by NTD 49% had AFP levels 5 MOM and 59% of these were associated with either abortion, stillbirth or fetus papyraceous. In twin pregnancies with serum AFP levels |
| doi_str_mv | 10.1111/j.1471-0528.1982.tb05032.x |
| format | Article |
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All 11 pregnancies discordant for NTD had serum AFP values >5 MOM and this level appears to be a suitable cut‐off point above which there should be further diagnostic investigations and monitoring of fetal well‐being.</description><identifier>ISSN: 1470-0328</identifier><identifier>ISSN: 0306-5456</identifier><identifier>EISSN: 1471-0528</identifier><identifier>DOI: 10.1111/j.1471-0528.1982.tb05032.x</identifier><identifier>PMID: 6181803</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>alpha-Fetoproteins - analysis ; Birth Weight ; Female ; Humans ; Neural Tube Defects - diagnosis ; Pregnancy ; Pregnancy Complications - diagnosis ; Pregnancy, Multiple ; Prenatal Diagnosis ; Twins</subject><ispartof>BJOG : an international journal of obstetrics and gynaecology, 1982-10, Vol.89 (10), p.817-820</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3697-f42b8c4835173b7b8f78e08c24d85084a7d8e88c95ba3b071eb2ee73a827fe553</citedby><cites>FETCH-LOGICAL-c3697-f42b8c4835173b7b8f78e08c24d85084a7d8e88c95ba3b071eb2ee73a827fe553</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1471-0528.1982.tb05032.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1471-0528.1982.tb05032.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,781,785,1418,27926,27927,45576,45577</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6181803$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>GHOSH, A.</creatorcontrib><creatorcontrib>WOO, J. S. K.</creatorcontrib><creatorcontrib>RAWLINSON, H. A.</creatorcontrib><creatorcontrib>FERGUSON‐SMITH, M. A.</creatorcontrib><title>Prognostic significance of raised serum α‐fetoprotein levels in twin pregnancies</title><title>BJOG : an international journal of obstetrics and gynaecology</title><addtitle>Br J Obstet Gynaecol</addtitle><description>Maternal serum α‐fetoprotein (AFP) was measured during the second trimester in 219 twin pregnancies uncomplicated by neural‐tube defects (NTD) and in 11 twin pregnancies discordant for NTD. Serum AFP levels were recorded in multiples of the median value (MOM) calculated from normal singleton pregnancies. Of the twin pregnancies uncomplicated by NTD 49% had AFP levels <2·5 MOM, 7·8% had levels >5 MOM and 59% of these were associated with either abortion, stillbirth or fetus papyraceous. In twin pregnancies with serum AFP levels <5 MOM an unsuccessful outcome was noted in only 4% (χ2, P<0·05). There was a significant negative correlation between serum AFP levels and combined birthweights (r=0·954). All 11 pregnancies discordant for NTD had serum AFP values >5 MOM and this level appears to be a suitable cut‐off point above which there should be further diagnostic investigations and monitoring of fetal well‐being.</description><subject>alpha-Fetoproteins - analysis</subject><subject>Birth Weight</subject><subject>Female</subject><subject>Humans</subject><subject>Neural Tube Defects - diagnosis</subject><subject>Pregnancy</subject><subject>Pregnancy Complications - diagnosis</subject><subject>Pregnancy, Multiple</subject><subject>Prenatal Diagnosis</subject><subject>Twins</subject><issn>1470-0328</issn><issn>0306-5456</issn><issn>1471-0528</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1982</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkE1OwzAQhS0EKlA4AlLEgl2Cf5J6ygIJKn5VqUjA2kqcSeUqTYqd0nbHEbgKF-EQnASHVt3jhT3Sm_dm_BFyymjE_DmfRCyWLKQJh4j1gUdNRhMqeLTcIQdbafevpqEXYJ8cOjehlPU4FR3S6TFgQMUBeX6y9biqXWN04My4MoXRaaUxqIvApsZhHji082nw_fXz8VlgU89s3aCpghLfsXSBr5qFv2YWx5V3GnRHZK9IS4fHm7dLXm9vXgb34XB09zC4GoZa9PoyLGKegY5BJEyKTGZQSEAKmsc5JBTiVOaAALqfZKnIqGSYcUQpUuCywCQRXXK2zvUrvc3RNWpqnMayTCus507JmMd9JoRvvFg3als7Z7FQM2umqV0pRlVLVE1Ui0212FRLVG2IqqU3n2ymzLMp5lvrBqHXL9f6wpS4-keyun4cgf_6L5nfiIA</recordid><startdate>198210</startdate><enddate>198210</enddate><creator>GHOSH, A.</creator><creator>WOO, J. 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A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3697-f42b8c4835173b7b8f78e08c24d85084a7d8e88c95ba3b071eb2ee73a827fe553</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1982</creationdate><topic>alpha-Fetoproteins - analysis</topic><topic>Birth Weight</topic><topic>Female</topic><topic>Humans</topic><topic>Neural Tube Defects - diagnosis</topic><topic>Pregnancy</topic><topic>Pregnancy Complications - diagnosis</topic><topic>Pregnancy, Multiple</topic><topic>Prenatal Diagnosis</topic><topic>Twins</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>GHOSH, A.</creatorcontrib><creatorcontrib>WOO, J. S. K.</creatorcontrib><creatorcontrib>RAWLINSON, H. A.</creatorcontrib><creatorcontrib>FERGUSON‐SMITH, M. A.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>BJOG : an international journal of obstetrics and gynaecology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>GHOSH, A.</au><au>WOO, J. S. K.</au><au>RAWLINSON, H. A.</au><au>FERGUSON‐SMITH, M. A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prognostic significance of raised serum α‐fetoprotein levels in twin pregnancies</atitle><jtitle>BJOG : an international journal of obstetrics and gynaecology</jtitle><addtitle>Br J Obstet Gynaecol</addtitle><date>1982-10</date><risdate>1982</risdate><volume>89</volume><issue>10</issue><spage>817</spage><epage>820</epage><pages>817-820</pages><issn>1470-0328</issn><issn>0306-5456</issn><eissn>1471-0528</eissn><abstract>Maternal serum α‐fetoprotein (AFP) was measured during the second trimester in 219 twin pregnancies uncomplicated by neural‐tube defects (NTD) and in 11 twin pregnancies discordant for NTD. Serum AFP levels were recorded in multiples of the median value (MOM) calculated from normal singleton pregnancies. Of the twin pregnancies uncomplicated by NTD 49% had AFP levels <2·5 MOM, 7·8% had levels >5 MOM and 59% of these were associated with either abortion, stillbirth or fetus papyraceous. In twin pregnancies with serum AFP levels <5 MOM an unsuccessful outcome was noted in only 4% (χ2, P<0·05). There was a significant negative correlation between serum AFP levels and combined birthweights (r=0·954). All 11 pregnancies discordant for NTD had serum AFP values >5 MOM and this level appears to be a suitable cut‐off point above which there should be further diagnostic investigations and monitoring of fetal well‐being.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>6181803</pmid><doi>10.1111/j.1471-0528.1982.tb05032.x</doi><tpages>4</tpages></addata></record> |
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| identifier | ISSN: 1470-0328 |
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| issn | 1470-0328 0306-5456 1471-0528 |
| language | eng |
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| source | MEDLINE; Wiley-Blackwell subscription journals; Alma/SFX Local Collection |
| subjects | alpha-Fetoproteins - analysis Birth Weight Female Humans Neural Tube Defects - diagnosis Pregnancy Pregnancy Complications - diagnosis Pregnancy, Multiple Prenatal Diagnosis Twins |
| title | Prognostic significance of raised serum α‐fetoprotein levels in twin pregnancies |
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