Synthetic progestins: In vitro potency on human endometrium and specific binding to cytosol receptor
The relative potency of six commonly used synthetic progestins has been evaluated in an organ culture system for human endometrium. The affinities of these progestins for endometrial progesterone receptor were also evaluated after removing the CBG-like protein by spheroidal hydroxylapatite chromatog...
Gespeichert in:
| Veröffentlicht in: | American journal of obstetrics and gynecology 1978-11, Vol.132 (5), p.549-554 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 554 |
|---|---|
| container_issue | 5 |
| container_start_page | 549 |
| container_title | American journal of obstetrics and gynecology |
| container_volume | 132 |
| creator | Shapiro, S.S. Dyer, R.D. Colás, A.E. |
| description | The relative potency of six commonly used synthetic progestins has been evaluated in an organ culture system for human endometrium. The affinities of these progestins for endometrial progesterone receptor were also evaluated after removing the CBG-like protein by spheroidal hydroxylapatite chromatography. All six progestins induced an increase in tissue glycogen during culture at lower concentrations than did progesterone; only one (medroxyprogesterone acetate) had a relative affinity greater than progesterone. The relative potencies and affinities of the synthetic progestins were found to have the same relative order but to differ in relative magnitude. |
| doi_str_mv | 10.1016/0002-9378(78)90751-2 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_74241696</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>0002937878907512</els_id><sourcerecordid>74241696</sourcerecordid><originalsourceid>FETCH-LOGICAL-c271t-38757a5029b43993c9c4f537434229e215b1951ffe101ddba86f2a5a502c55c33</originalsourceid><addsrcrecordid>eNp9kEtLxTAQhYP4uj7-gYusRBfVJG2axoUg4gsEF-o6tMlUI7dJTVLh_ntTr7gUBsIw5xxyPoSOKDmjhNbnhBBWyFI0J6I5lURwWrANtKBEiqJu6mYTLf4ku2gvxo95ZZLtoG1BRcX5ApnnlUvvkKzGY_BvEJN18QI_OPxlU_B49AmcXmHv8Ps0tA6DM36AFOw04NYZHEfQts_2zjpj3RtOHutV8tEvcQANY_LhAG317TLC4e-7j15vb16u74vHp7uH66vHQjNBU1E2gouWEya7qpSy1FJXPS9FVVb518Ao76jktO8h1zema5u6Zy2fHZpzXZb76Hidm6t8TrmLGmzUsFy2DvwUlahYRWtZZ2G1FurgYwzQqzHYoQ0rRYma2aqZlJrBqTw_bBXLtqPf_KkbwPyZ1jDz-XJ9htzxy0JQUdtMD4zNJJIy3v6f_w3R6oj7</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>74241696</pqid></control><display><type>article</type><title>Synthetic progestins: In vitro potency on human endometrium and specific binding to cytosol receptor</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Shapiro, S.S. ; Dyer, R.D. ; Colás, A.E.</creator><creatorcontrib>Shapiro, S.S. ; Dyer, R.D. ; Colás, A.E.</creatorcontrib><description>The relative potency of six commonly used synthetic progestins has been evaluated in an organ culture system for human endometrium. The affinities of these progestins for endometrial progesterone receptor were also evaluated after removing the CBG-like protein by spheroidal hydroxylapatite chromatography. All six progestins induced an increase in tissue glycogen during culture at lower concentrations than did progesterone; only one (medroxyprogesterone acetate) had a relative affinity greater than progesterone. The relative potencies and affinities of the synthetic progestins were found to have the same relative order but to differ in relative magnitude.</description><identifier>ISSN: 0002-9378</identifier><identifier>EISSN: 1097-6868</identifier><identifier>DOI: 10.1016/0002-9378(78)90751-2</identifier><identifier>PMID: 717455</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Chromatography ; Cytosol - metabolism ; Endometrium - drug effects ; Endometrium - metabolism ; Ethynodiol Diacetate - metabolism ; Female ; Glycogen - metabolism ; Humans ; Medroxyprogesterone - metabolism ; Medroxyprogesterone - pharmacology ; Norethindrone - metabolism ; Norethynodrel - metabolism ; Norgestrel - metabolism ; Organ Culture Techniques ; Progesterone - metabolism ; Progesterone Congeners - metabolism ; Progesterone Congeners - pharmacology ; Receptors, Progesterone - metabolism</subject><ispartof>American journal of obstetrics and gynecology, 1978-11, Vol.132 (5), p.549-554</ispartof><rights>1978</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c271t-38757a5029b43993c9c4f537434229e215b1951ffe101ddba86f2a5a502c55c33</citedby><cites>FETCH-LOGICAL-c271t-38757a5029b43993c9c4f537434229e215b1951ffe101ddba86f2a5a502c55c33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/0002937878907512$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/717455$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shapiro, S.S.</creatorcontrib><creatorcontrib>Dyer, R.D.</creatorcontrib><creatorcontrib>Colás, A.E.</creatorcontrib><title>Synthetic progestins: In vitro potency on human endometrium and specific binding to cytosol receptor</title><title>American journal of obstetrics and gynecology</title><addtitle>Am J Obstet Gynecol</addtitle><description>The relative potency of six commonly used synthetic progestins has been evaluated in an organ culture system for human endometrium. The affinities of these progestins for endometrial progesterone receptor were also evaluated after removing the CBG-like protein by spheroidal hydroxylapatite chromatography. All six progestins induced an increase in tissue glycogen during culture at lower concentrations than did progesterone; only one (medroxyprogesterone acetate) had a relative affinity greater than progesterone. The relative potencies and affinities of the synthetic progestins were found to have the same relative order but to differ in relative magnitude.</description><subject>Chromatography</subject><subject>Cytosol - metabolism</subject><subject>Endometrium - drug effects</subject><subject>Endometrium - metabolism</subject><subject>Ethynodiol Diacetate - metabolism</subject><subject>Female</subject><subject>Glycogen - metabolism</subject><subject>Humans</subject><subject>Medroxyprogesterone - metabolism</subject><subject>Medroxyprogesterone - pharmacology</subject><subject>Norethindrone - metabolism</subject><subject>Norethynodrel - metabolism</subject><subject>Norgestrel - metabolism</subject><subject>Organ Culture Techniques</subject><subject>Progesterone - metabolism</subject><subject>Progesterone Congeners - metabolism</subject><subject>Progesterone Congeners - pharmacology</subject><subject>Receptors, Progesterone - metabolism</subject><issn>0002-9378</issn><issn>1097-6868</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1978</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEtLxTAQhYP4uj7-gYusRBfVJG2axoUg4gsEF-o6tMlUI7dJTVLh_ntTr7gUBsIw5xxyPoSOKDmjhNbnhBBWyFI0J6I5lURwWrANtKBEiqJu6mYTLf4ku2gvxo95ZZLtoG1BRcX5ApnnlUvvkKzGY_BvEJN18QI_OPxlU_B49AmcXmHv8Ps0tA6DM36AFOw04NYZHEfQts_2zjpj3RtOHutV8tEvcQANY_LhAG317TLC4e-7j15vb16u74vHp7uH66vHQjNBU1E2gouWEya7qpSy1FJXPS9FVVb518Ao76jktO8h1zema5u6Zy2fHZpzXZb76Hidm6t8TrmLGmzUsFy2DvwUlahYRWtZZ2G1FurgYwzQqzHYoQ0rRYma2aqZlJrBqTw_bBXLtqPf_KkbwPyZ1jDz-XJ9htzxy0JQUdtMD4zNJJIy3v6f_w3R6oj7</recordid><startdate>19781101</startdate><enddate>19781101</enddate><creator>Shapiro, S.S.</creator><creator>Dyer, R.D.</creator><creator>Colás, A.E.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19781101</creationdate><title>Synthetic progestins: In vitro potency on human endometrium and specific binding to cytosol receptor</title><author>Shapiro, S.S. ; Dyer, R.D. ; Colás, A.E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c271t-38757a5029b43993c9c4f537434229e215b1951ffe101ddba86f2a5a502c55c33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1978</creationdate><topic>Chromatography</topic><topic>Cytosol - metabolism</topic><topic>Endometrium - drug effects</topic><topic>Endometrium - metabolism</topic><topic>Ethynodiol Diacetate - metabolism</topic><topic>Female</topic><topic>Glycogen - metabolism</topic><topic>Humans</topic><topic>Medroxyprogesterone - metabolism</topic><topic>Medroxyprogesterone - pharmacology</topic><topic>Norethindrone - metabolism</topic><topic>Norethynodrel - metabolism</topic><topic>Norgestrel - metabolism</topic><topic>Organ Culture Techniques</topic><topic>Progesterone - metabolism</topic><topic>Progesterone Congeners - metabolism</topic><topic>Progesterone Congeners - pharmacology</topic><topic>Receptors, Progesterone - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shapiro, S.S.</creatorcontrib><creatorcontrib>Dyer, R.D.</creatorcontrib><creatorcontrib>Colás, A.E.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of obstetrics and gynecology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shapiro, S.S.</au><au>Dyer, R.D.</au><au>Colás, A.E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Synthetic progestins: In vitro potency on human endometrium and specific binding to cytosol receptor</atitle><jtitle>American journal of obstetrics and gynecology</jtitle><addtitle>Am J Obstet Gynecol</addtitle><date>1978-11-01</date><risdate>1978</risdate><volume>132</volume><issue>5</issue><spage>549</spage><epage>554</epage><pages>549-554</pages><issn>0002-9378</issn><eissn>1097-6868</eissn><abstract>The relative potency of six commonly used synthetic progestins has been evaluated in an organ culture system for human endometrium. The affinities of these progestins for endometrial progesterone receptor were also evaluated after removing the CBG-like protein by spheroidal hydroxylapatite chromatography. All six progestins induced an increase in tissue glycogen during culture at lower concentrations than did progesterone; only one (medroxyprogesterone acetate) had a relative affinity greater than progesterone. The relative potencies and affinities of the synthetic progestins were found to have the same relative order but to differ in relative magnitude.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>717455</pmid><doi>10.1016/0002-9378(78)90751-2</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0002-9378 |
| ispartof | American journal of obstetrics and gynecology, 1978-11, Vol.132 (5), p.549-554 |
| issn | 0002-9378 1097-6868 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_74241696 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Chromatography Cytosol - metabolism Endometrium - drug effects Endometrium - metabolism Ethynodiol Diacetate - metabolism Female Glycogen - metabolism Humans Medroxyprogesterone - metabolism Medroxyprogesterone - pharmacology Norethindrone - metabolism Norethynodrel - metabolism Norgestrel - metabolism Organ Culture Techniques Progesterone - metabolism Progesterone Congeners - metabolism Progesterone Congeners - pharmacology Receptors, Progesterone - metabolism |
| title | Synthetic progestins: In vitro potency on human endometrium and specific binding to cytosol receptor |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-01T15%3A33%3A01IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Synthetic%20progestins:%20In%20vitro%20potency%20on%20human%20endometrium%20and%20specific%20binding%20to%20cytosol%20receptor&rft.jtitle=American%20journal%20of%20obstetrics%20and%20gynecology&rft.au=Shapiro,%20S.S.&rft.date=1978-11-01&rft.volume=132&rft.issue=5&rft.spage=549&rft.epage=554&rft.pages=549-554&rft.issn=0002-9378&rft.eissn=1097-6868&rft_id=info:doi/10.1016/0002-9378(78)90751-2&rft_dat=%3Cproquest_cross%3E74241696%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=74241696&rft_id=info:pmid/717455&rft_els_id=0002937878907512&rfr_iscdi=true |