Interaction of anthracycline antibiotics with actin and heavy meromyosin

For the purpose of elucidating the biochemical mechanism of anthracycline cardiomyopathy, the interaction with actin and heavy meromyosin (HMM) was studied. HMM and acto-HMM Mg 2+-ATPase reactions were inhibited by daunorubicin and adriamycin; but not significantly by aclacinomycin A. The three anti...

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Veröffentlicht in:	Biochemical and biophysical research communications 1978-12, Vol.85 (4), p.1542-1550
Hauptverfasser:	Someya, Akira, Akiyama, Tetsu, Misumi, Masarou, Tanaka, Nobuo
Format:	Artikel
Sprache:	eng
Schlagworte:	Actins - metabolism Adenosine Triphosphatases - metabolism Aminoglycosides Animals Antibiotics, Antineoplastic - pharmacology Daunorubicin - pharmacology Doxorubicin - pharmacology Kinetics Macromolecular Substances Magnesium - pharmacology Muscles - enzymology Myosin Subfragments Protein Binding Rabbits Spectrometry, Fluorescence Spectrophotometry
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