The effect of cimetidine and 15(S) 15-methyl prostaglandin E2 on the healing of laser-induced gastric mucosal damage
Delayed perforation, a complication of laser photocoagulation, could be reduced by accelerating healing and inhibiting gastric secretion. With the use of the Nd:YAG laser, a beam was passed through a single glass fiber (400 micrometer) with 10 degrees divergence at a constant power of 80 W for 1 sec...
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| Veröffentlicht in: | Gastrointestinal endoscopy 1982-08, Vol.28 (3), p.166-168 |
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| container_title | Gastrointestinal endoscopy |
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| creator | MacLeod, I A Lee, F D Lewi, H J Joffe, S N |
| description | Delayed perforation, a complication of laser photocoagulation, could be reduced by accelerating healing and inhibiting gastric secretion. With the use of the Nd:YAG laser, a beam was passed through a single glass fiber (400 micrometer) with 10 degrees divergence at a constant power of 80 W for 1 sec at a 1-cm distance from the gastric mucosa. Rats were then randomly allocated to receive cimetidine (50 mg/kg), 15(S)15-methyl prostaglandin E2 (50 micrograms/kg), or saline intraperitoneally twice daily for 4 or 7 days. The surface area of ulceration at 4 days for the control rats and the cimetidine- and prostaglandin-treated rats was 29, 34, and 28 mm2, respectively, and was much larger than the initial lesion of 15 mm2. Histologically, all lesions showed the typical appearances of peptic ulceration with perforation in half the prostaglandin-treated rats. By 7 days, the surface area in the cimetidine-treated rats appeared to decrease, but the light microscopic changes were similar to the saline- and prostaglandin-treated rats. Neither cimetidine nor prostaglandin enhanced healing in this study. |
| doi_str_mv | 10.1016/S0016-5107(82)73043-3 |
| format | Article |
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With the use of the Nd:YAG laser, a beam was passed through a single glass fiber (400 micrometer) with 10 degrees divergence at a constant power of 80 W for 1 sec at a 1-cm distance from the gastric mucosa. Rats were then randomly allocated to receive cimetidine (50 mg/kg), 15(S)15-methyl prostaglandin E2 (50 micrograms/kg), or saline intraperitoneally twice daily for 4 or 7 days. The surface area of ulceration at 4 days for the control rats and the cimetidine- and prostaglandin-treated rats was 29, 34, and 28 mm2, respectively, and was much larger than the initial lesion of 15 mm2. Histologically, all lesions showed the typical appearances of peptic ulceration with perforation in half the prostaglandin-treated rats. By 7 days, the surface area in the cimetidine-treated rats appeared to decrease, but the light microscopic changes were similar to the saline- and prostaglandin-treated rats. Neither cimetidine nor prostaglandin enhanced healing in this study.</description><identifier>ISSN: 0016-5107</identifier><identifier>DOI: 10.1016/S0016-5107(82)73043-3</identifier><identifier>PMID: 6890004</identifier><language>eng</language><publisher>United States</publisher><subject>Animals ; Cimetidine - pharmacology ; Gastric Mucosa - drug effects ; Guanidines - pharmacology ; Laser Therapy ; Lasers - adverse effects ; Lasers - instrumentation ; Lasers - methods ; Male ; Peptic Ulcer - etiology ; Peptic Ulcer - pathology ; Peptic Ulcer Perforation - etiology ; Prostaglandins E, Synthetic - pharmacology ; Rats ; Rats, Inbred Strains ; Wound Healing - drug effects</subject><ispartof>Gastrointestinal endoscopy, 1982-08, Vol.28 (3), p.166-168</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c304t-feeab4838bec282b9902ab99383dec7e3efd89afd7a55e60c2167662825e9fb93</citedby><cites>FETCH-LOGICAL-c304t-feeab4838bec282b9902ab99383dec7e3efd89afd7a55e60c2167662825e9fb93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6890004$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>MacLeod, I A</creatorcontrib><creatorcontrib>Lee, F D</creatorcontrib><creatorcontrib>Lewi, H J</creatorcontrib><creatorcontrib>Joffe, S N</creatorcontrib><title>The effect of cimetidine and 15(S) 15-methyl prostaglandin E2 on the healing of laser-induced gastric mucosal damage</title><title>Gastrointestinal endoscopy</title><addtitle>Gastrointest Endosc</addtitle><description>Delayed perforation, a complication of laser photocoagulation, could be reduced by accelerating healing and inhibiting gastric secretion. With the use of the Nd:YAG laser, a beam was passed through a single glass fiber (400 micrometer) with 10 degrees divergence at a constant power of 80 W for 1 sec at a 1-cm distance from the gastric mucosa. Rats were then randomly allocated to receive cimetidine (50 mg/kg), 15(S)15-methyl prostaglandin E2 (50 micrograms/kg), or saline intraperitoneally twice daily for 4 or 7 days. The surface area of ulceration at 4 days for the control rats and the cimetidine- and prostaglandin-treated rats was 29, 34, and 28 mm2, respectively, and was much larger than the initial lesion of 15 mm2. Histologically, all lesions showed the typical appearances of peptic ulceration with perforation in half the prostaglandin-treated rats. By 7 days, the surface area in the cimetidine-treated rats appeared to decrease, but the light microscopic changes were similar to the saline- and prostaglandin-treated rats. Neither cimetidine nor prostaglandin enhanced healing in this study.</description><subject>Animals</subject><subject>Cimetidine - pharmacology</subject><subject>Gastric Mucosa - drug effects</subject><subject>Guanidines - pharmacology</subject><subject>Laser Therapy</subject><subject>Lasers - adverse effects</subject><subject>Lasers - instrumentation</subject><subject>Lasers - methods</subject><subject>Male</subject><subject>Peptic Ulcer - etiology</subject><subject>Peptic Ulcer - pathology</subject><subject>Peptic Ulcer Perforation - etiology</subject><subject>Prostaglandins E, Synthetic - pharmacology</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Wound Healing - drug effects</subject><issn>0016-5107</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1982</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kDlvAjEQhV0kIoTkJyC5ikixiY89vGWEyCEhpYDUltceg6M9yNpb8O_jBUTzLI_fPM98CM0peaGE5q8bEjXJKCkWgj0XnKQ84Tdoei3foXvvfwkhgnE6QZNclPGSTlHY7gGDtaAD7izWroHgjGsBq9Zgmi02z1GTWN0fa3zoOx_Uro5vrsUrhrsWhxiwB1W7djcm1MpDn7jWDBoM3ikfeqdxM-jOqxob1agdPKBbq2oPj5dzhn7eV9vlZ7L-_vhavq0THTcIiQVQVSq4qEAzwaqyJExF5YIb0AVwsEaUyppCZRnkRDOaF3kerRmUtir5DD2dc-PcfwP4IBvnNdRxfugGL4uU8SynPBqzs1HHBX0PVh5616j-KCmRI2F5IixHlFIweSIsx7755YOhasBcuy54-T8te3i4</recordid><startdate>198208</startdate><enddate>198208</enddate><creator>MacLeod, I A</creator><creator>Lee, F D</creator><creator>Lewi, H J</creator><creator>Joffe, S N</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198208</creationdate><title>The effect of cimetidine and 15(S) 15-methyl prostaglandin E2 on the healing of laser-induced gastric mucosal damage</title><author>MacLeod, I A ; Lee, F D ; Lewi, H J ; Joffe, S N</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c304t-feeab4838bec282b9902ab99383dec7e3efd89afd7a55e60c2167662825e9fb93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1982</creationdate><topic>Animals</topic><topic>Cimetidine - pharmacology</topic><topic>Gastric Mucosa - drug effects</topic><topic>Guanidines - pharmacology</topic><topic>Laser Therapy</topic><topic>Lasers - adverse effects</topic><topic>Lasers - instrumentation</topic><topic>Lasers - methods</topic><topic>Male</topic><topic>Peptic Ulcer - etiology</topic><topic>Peptic Ulcer - pathology</topic><topic>Peptic Ulcer Perforation - etiology</topic><topic>Prostaglandins E, Synthetic - pharmacology</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Wound Healing - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>MacLeod, I A</creatorcontrib><creatorcontrib>Lee, F D</creatorcontrib><creatorcontrib>Lewi, H J</creatorcontrib><creatorcontrib>Joffe, S N</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Gastrointestinal endoscopy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>MacLeod, I A</au><au>Lee, F D</au><au>Lewi, H J</au><au>Joffe, S N</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The effect of cimetidine and 15(S) 15-methyl prostaglandin E2 on the healing of laser-induced gastric mucosal damage</atitle><jtitle>Gastrointestinal endoscopy</jtitle><addtitle>Gastrointest Endosc</addtitle><date>1982-08</date><risdate>1982</risdate><volume>28</volume><issue>3</issue><spage>166</spage><epage>168</epage><pages>166-168</pages><issn>0016-5107</issn><abstract>Delayed perforation, a complication of laser photocoagulation, could be reduced by accelerating healing and inhibiting gastric secretion. With the use of the Nd:YAG laser, a beam was passed through a single glass fiber (400 micrometer) with 10 degrees divergence at a constant power of 80 W for 1 sec at a 1-cm distance from the gastric mucosa. Rats were then randomly allocated to receive cimetidine (50 mg/kg), 15(S)15-methyl prostaglandin E2 (50 micrograms/kg), or saline intraperitoneally twice daily for 4 or 7 days. The surface area of ulceration at 4 days for the control rats and the cimetidine- and prostaglandin-treated rats was 29, 34, and 28 mm2, respectively, and was much larger than the initial lesion of 15 mm2. Histologically, all lesions showed the typical appearances of peptic ulceration with perforation in half the prostaglandin-treated rats. By 7 days, the surface area in the cimetidine-treated rats appeared to decrease, but the light microscopic changes were similar to the saline- and prostaglandin-treated rats. Neither cimetidine nor prostaglandin enhanced healing in this study.</abstract><cop>United States</cop><pmid>6890004</pmid><doi>10.1016/S0016-5107(82)73043-3</doi><tpages>3</tpages></addata></record> |
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| ispartof | Gastrointestinal endoscopy, 1982-08, Vol.28 (3), p.166-168 |
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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Cimetidine - pharmacology Gastric Mucosa - drug effects Guanidines - pharmacology Laser Therapy Lasers - adverse effects Lasers - instrumentation Lasers - methods Male Peptic Ulcer - etiology Peptic Ulcer - pathology Peptic Ulcer Perforation - etiology Prostaglandins E, Synthetic - pharmacology Rats Rats, Inbred Strains Wound Healing - drug effects |
| title | The effect of cimetidine and 15(S) 15-methyl prostaglandin E2 on the healing of laser-induced gastric mucosal damage |
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