AN ASSESSMENT OF GASTROINTESTINAL MUCOSAL DAMAGE IN VIVO : ENHANCEMENT OF URINARY RECOVERY AFTER ORAL ADMINISTRATION OF PHENOLSULFONPHTHALEIN IN ULCER RATS

The permeability of phenolsulfonphthalein (phenol red), a poorly absorbed drug, was examined as an index of an assessment of gastrointestinal mucosal damage. The urinary recovery after oral administration of phenol red was significantly increased in rats with indomethacin-induced ulcers. A similar r...

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Veröffentlicht in:	Chemical & pharmaceutical bulletin 1982/06/25, Vol.30(6), pp.2291-2293
Hauptverfasser:	Nakamura, Junzo, Takada, Shigeyuki, Ohtsuka, Noboru, Heya, Toshiro, Yamamoto, Akira, Kimura, Toshikiro, Sezaki, Hitoshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Gastric Mucosa - drug effects gastrointestinal absorption Intestinal Mucosa - drug effects Phenolphthaleins Phenolsulfonphthalein - urine Rats Rats, Inbred Strains Stomach Ulcer - diagnosis
Online-Zugang:	Volltext
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