AN ASSESSMENT OF GASTROINTESTINAL MUCOSAL DAMAGE IN VIVO : ENHANCEMENT OF URINARY RECOVERY AFTER ORAL ADMINISTRATION OF PHENOLSULFONPHTHALEIN IN ULCER RATS
The permeability of phenolsulfonphthalein (phenol red), a poorly absorbed drug, was examined as an index of an assessment of gastrointestinal mucosal damage. The urinary recovery after oral administration of phenol red was significantly increased in rats with indomethacin-induced ulcers. A similar r...
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Veröffentlicht in: | Chemical & pharmaceutical bulletin 1982/06/25, Vol.30(6), pp.2291-2293 |
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creator | Nakamura, Junzo Takada, Shigeyuki Ohtsuka, Noboru Heya, Toshiro Yamamoto, Akira Kimura, Toshikiro Sezaki, Hitoshi |
description | The permeability of phenolsulfonphthalein (phenol red), a poorly absorbed drug, was examined as an index of an assessment of gastrointestinal mucosal damage. The urinary recovery after oral administration of phenol red was significantly increased in rats with indomethacin-induced ulcers. A similar result was obtained in rats with ulcers induced by restraint and water immersion stress. However, the urinary recoveries of phenol red after the intravenous administration in both types of ulcerated rats did not change compared with the controls. These findings suggest that the increase in urinary recovery of phenol red is due to increased gastrointestinal absorption. This method may be utilized as a simple, useful, and noninvasive screening test for an assessment of gastrointestinal mucosal damage in vivo. |
doi_str_mv | 10.1248/cpb.30.2291 |
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The urinary recovery after oral administration of phenol red was significantly increased in rats with indomethacin-induced ulcers. A similar result was obtained in rats with ulcers induced by restraint and water immersion stress. However, the urinary recoveries of phenol red after the intravenous administration in both types of ulcerated rats did not change compared with the controls. These findings suggest that the increase in urinary recovery of phenol red is due to increased gastrointestinal absorption. This method may be utilized as a simple, useful, and noninvasive screening test for an assessment of gastrointestinal mucosal damage in vivo.</description><identifier>ISSN: 0009-2363</identifier><identifier>EISSN: 1347-5223</identifier><identifier>DOI: 10.1248/cpb.30.2291</identifier><identifier>PMID: 7127612</identifier><language>eng</language><publisher>Japan: The Pharmaceutical Society of Japan</publisher><subject>Animals ; Gastric Mucosa - drug effects ; gastrointestinal absorption ; Intestinal Mucosa - drug effects ; Phenolphthaleins ; Phenolsulfonphthalein - urine ; Rats ; Rats, Inbred Strains ; Stomach Ulcer - diagnosis</subject><ispartof>Chemical and Pharmaceutical Bulletin, 1982/06/25, Vol.30(6), pp.2291-2293</ispartof><rights>The Pharmaceutical Society of Japan</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4641-6aed781b591ed267c1eed7baef9a1d71d3b5826bdbd2c8418d9e182a239b3dac3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1877,4010,27900,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7127612$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nakamura, Junzo</creatorcontrib><creatorcontrib>Takada, Shigeyuki</creatorcontrib><creatorcontrib>Ohtsuka, Noboru</creatorcontrib><creatorcontrib>Heya, Toshiro</creatorcontrib><creatorcontrib>Yamamoto, Akira</creatorcontrib><creatorcontrib>Kimura, Toshikiro</creatorcontrib><creatorcontrib>Sezaki, Hitoshi</creatorcontrib><title>AN ASSESSMENT OF GASTROINTESTINAL MUCOSAL DAMAGE IN VIVO : ENHANCEMENT OF URINARY RECOVERY AFTER ORAL ADMINISTRATION OF PHENOLSULFONPHTHALEIN IN ULCER RATS</title><title>Chemical & pharmaceutical bulletin</title><addtitle>Chem. Pharm. Bull.</addtitle><description>The permeability of phenolsulfonphthalein (phenol red), a poorly absorbed drug, was examined as an index of an assessment of gastrointestinal mucosal damage. The urinary recovery after oral administration of phenol red was significantly increased in rats with indomethacin-induced ulcers. A similar result was obtained in rats with ulcers induced by restraint and water immersion stress. However, the urinary recoveries of phenol red after the intravenous administration in both types of ulcerated rats did not change compared with the controls. These findings suggest that the increase in urinary recovery of phenol red is due to increased gastrointestinal absorption. This method may be utilized as a simple, useful, and noninvasive screening test for an assessment of gastrointestinal mucosal damage in vivo.</description><subject>Animals</subject><subject>Gastric Mucosa - drug effects</subject><subject>gastrointestinal absorption</subject><subject>Intestinal Mucosa - drug effects</subject><subject>Phenolphthaleins</subject><subject>Phenolsulfonphthalein - urine</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Stomach Ulcer - diagnosis</subject><issn>0009-2363</issn><issn>1347-5223</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1982</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkUuP0zAURi0EGsrAijWSV2xQih95srNSt4mU2qM4qcQqcmIXOmqnJW4X_Jb5s-OoZZAs3yt_556FLwCfMZpjEqbfh1M_p2hOSIbfgBmmYRJEhNC3YIYQygJCY_oefHDuESESoYTegbsEkyTGZAaemYBMKa7UmosGyiVcMdXUshQNV00pWAXXbS6Vrwu2ZisOSwE35UbCH5CLgomc_xtsa4_XP2HNc7nhvmHLhtdQ1n6WLdalKL2YNaUUE_1QcCEr1VZLKR6KpmAV92Z_2ir3Ux5UH8G7rd47--lW70G75E1eBJVclTmrgiGMQxzE2pokxX2UYWtInAzY-ode222msUmwoX2Ukrg3vSFDGuLUZBanRBOa9dTogd6Dr1fvaTz-uVh37g47N9j9Xj_Z48V1SUhoiFHmwW9XcBiPzo12253G3UGPfzuMumkVnV9FR1E3rcLTX27aS3-w5pW9_b3PF9f80Z31L_ua6_G8G_Z2cuEsSidffL0m7f_4tx47-0RfAGh_kP8</recordid><startdate>1982</startdate><enddate>1982</enddate><creator>Nakamura, Junzo</creator><creator>Takada, Shigeyuki</creator><creator>Ohtsuka, Noboru</creator><creator>Heya, Toshiro</creator><creator>Yamamoto, Akira</creator><creator>Kimura, Toshikiro</creator><creator>Sezaki, Hitoshi</creator><general>The Pharmaceutical Society of Japan</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1982</creationdate><title>AN ASSESSMENT OF GASTROINTESTINAL MUCOSAL DAMAGE IN VIVO : ENHANCEMENT OF URINARY RECOVERY AFTER ORAL ADMINISTRATION OF PHENOLSULFONPHTHALEIN IN ULCER RATS</title><author>Nakamura, Junzo ; Takada, Shigeyuki ; Ohtsuka, Noboru ; Heya, Toshiro ; Yamamoto, Akira ; Kimura, Toshikiro ; Sezaki, Hitoshi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4641-6aed781b591ed267c1eed7baef9a1d71d3b5826bdbd2c8418d9e182a239b3dac3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1982</creationdate><topic>Animals</topic><topic>Gastric Mucosa - drug effects</topic><topic>gastrointestinal absorption</topic><topic>Intestinal Mucosa - drug effects</topic><topic>Phenolphthaleins</topic><topic>Phenolsulfonphthalein - urine</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Stomach Ulcer - diagnosis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nakamura, Junzo</creatorcontrib><creatorcontrib>Takada, Shigeyuki</creatorcontrib><creatorcontrib>Ohtsuka, Noboru</creatorcontrib><creatorcontrib>Heya, Toshiro</creatorcontrib><creatorcontrib>Yamamoto, Akira</creatorcontrib><creatorcontrib>Kimura, Toshikiro</creatorcontrib><creatorcontrib>Sezaki, Hitoshi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Chemical & pharmaceutical bulletin</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nakamura, Junzo</au><au>Takada, Shigeyuki</au><au>Ohtsuka, Noboru</au><au>Heya, Toshiro</au><au>Yamamoto, Akira</au><au>Kimura, Toshikiro</au><au>Sezaki, Hitoshi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>AN ASSESSMENT OF GASTROINTESTINAL MUCOSAL DAMAGE IN VIVO : ENHANCEMENT OF URINARY RECOVERY AFTER ORAL ADMINISTRATION OF PHENOLSULFONPHTHALEIN IN ULCER RATS</atitle><jtitle>Chemical & pharmaceutical bulletin</jtitle><addtitle>Chem. Pharm. Bull.</addtitle><date>1982</date><risdate>1982</risdate><volume>30</volume><issue>6</issue><spage>2291</spage><epage>2293</epage><pages>2291-2293</pages><issn>0009-2363</issn><eissn>1347-5223</eissn><abstract>The permeability of phenolsulfonphthalein (phenol red), a poorly absorbed drug, was examined as an index of an assessment of gastrointestinal mucosal damage. The urinary recovery after oral administration of phenol red was significantly increased in rats with indomethacin-induced ulcers. A similar result was obtained in rats with ulcers induced by restraint and water immersion stress. However, the urinary recoveries of phenol red after the intravenous administration in both types of ulcerated rats did not change compared with the controls. These findings suggest that the increase in urinary recovery of phenol red is due to increased gastrointestinal absorption. This method may be utilized as a simple, useful, and noninvasive screening test for an assessment of gastrointestinal mucosal damage in vivo.</abstract><cop>Japan</cop><pub>The Pharmaceutical Society of Japan</pub><pmid>7127612</pmid><doi>10.1248/cpb.30.2291</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record> |
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subjects | Animals Gastric Mucosa - drug effects gastrointestinal absorption Intestinal Mucosa - drug effects Phenolphthaleins Phenolsulfonphthalein - urine Rats Rats, Inbred Strains Stomach Ulcer - diagnosis |
title | AN ASSESSMENT OF GASTROINTESTINAL MUCOSAL DAMAGE IN VIVO : ENHANCEMENT OF URINARY RECOVERY AFTER ORAL ADMINISTRATION OF PHENOLSULFONPHTHALEIN IN ULCER RATS |
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