Treatment with essential amino acids in patients on chronic hemodialysis: a double blind cross-over study
Extract: Patients on chronic hemodialysis may suffer from a latent protein deficiency, and therapy with essential amino acids has been recommended. In a double blind cross-over study, 13 hemodialysis patients received orally 15.7 g of essential amino acids daily over a 3-month period. Patients were...
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| Veröffentlicht in: | The American journal of clinical nutrition 1978-10, Vol.31 (10), p.1821-1826 |
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| container_end_page | 1826 |
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| container_issue | 10 |
| container_start_page | 1821 |
| container_title | The American journal of clinical nutrition |
| container_volume | 31 |
| creator | Hecking, Erwin Kohler, Heide Zobel, Rainer Lemmel, Ernst M Mader, Hans Opferkuch, Wolfgang Prellwitz, Winfried Keim, Hans J Muller, Doris |
| description | Extract: Patients on chronic hemodialysis may suffer from a latent protein deficiency, and therapy with essential amino acids has been recommended. In a double blind cross-over study, 13 hemodialysis patients received orally 15.7 g of essential amino acids daily over a 3-month period. Patients were on a liberal diet, containing 1 g of protein per kilogram of body weight per day. Hemodialysis was adequate. Therapy resulted in an increase in urea, uric acid, C3 c complement factor and a fall in C4. Lysine levels increased and phenylalanine fell. Malnutrition could not account for the observed metabolic changes, which are more likely due to uremic metabolic disturbances. A liberal diet of 1 g of protein per kilogram of body weight appears sufficient for patients on hemodialysis. Treatment with essential amino acids offers no advantage |
| doi_str_mv | 10.1093/ajcn/31.10.1821 |
| format | Article |
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In a double blind cross-over study, 13 hemodialysis patients received orally 15.7 g of essential amino acids daily over a 3-month period. Patients were on a liberal diet, containing 1 g of protein per kilogram of body weight per day. Hemodialysis was adequate. Therapy resulted in an increase in urea, uric acid, C3 c complement factor and a fall in C4. Lysine levels increased and phenylalanine fell. Malnutrition could not account for the observed metabolic changes, which are more likely due to uremic metabolic disturbances. A liberal diet of 1 g of protein per kilogram of body weight appears sufficient for patients on hemodialysis. Treatment with essential amino acids offers no advantage</description><subject>Adult</subject><subject>Amino Acids, Essential - therapeutic use</subject><subject>Clinical Trials as Topic</subject><subject>Complement C3 - metabolism</subject><subject>Female</subject><subject>Glomerulonephritis - metabolism</subject><subject>Glomerulonephritis - therapy</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Prealbumin - metabolism</subject><subject>Protein Deficiency - prevention & control</subject><subject>Pyelonephritis - metabolism</subject><subject>Pyelonephritis - therapy</subject><subject>Renal Dialysis</subject><subject>Retinol-Binding Proteins - blood</subject><subject>Transferrin - metabolism</subject><issn>0002-9165</issn><issn>1938-3207</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1978</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9UMlOwzAQtRBbKZyREAefuKX1kjgxN1SxSZU4AGdrHDvUKImLnYD697gt4jTz5i0aPYQuKZlRIvkcPut-zulsiytGD9CESl5lnJHyEE0IISyTVBSn6CzGT0Ioyytxgo65IBWVE-TegoWhs_2Af9ywwjbGtDtoMXSu9xhqZyJ2PV7D4BITse9xvQq-dzVe2c6bpN1EF28xYONH3VqsW9cbXAcfY-a_bcBxGM3mHB010EZ78Ten6P3h_m3xlC1fHp8Xd8usZkLQrBFlXjAKwhowXDeGVLzgTQklB0a5NpXVMmfMUF1KA5UUuhGVyNNVJ0D4FN3sc9fBf402DqpzsbZtC731Y1RlMhec5kk43wt3nwbbqHVwHYSNokRtu1XbbhWnO5y6TY7rv-hRd9b86_dlJvpqTzfgFXwEF9X7aylzIfOc_wKdKH71</recordid><startdate>197810</startdate><enddate>197810</enddate><creator>Hecking, Erwin</creator><creator>Kohler, Heide</creator><creator>Zobel, Rainer</creator><creator>Lemmel, Ernst M</creator><creator>Mader, Hans</creator><creator>Opferkuch, Wolfgang</creator><creator>Prellwitz, Winfried</creator><creator>Keim, Hans J</creator><creator>Muller, Doris</creator><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>197810</creationdate><title>Treatment with essential amino acids in patients on chronic hemodialysis: a double blind cross-over study</title><author>Hecking, Erwin ; Kohler, Heide ; Zobel, Rainer ; Lemmel, Ernst M ; Mader, Hans ; Opferkuch, Wolfgang ; Prellwitz, Winfried ; Keim, Hans J ; Muller, Doris</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2661-f674521a6edad3bfd08353f7a73a213bd8eb9422d1b79da896bf6864eb9b89603</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1978</creationdate><topic>Adult</topic><topic>Amino Acids, Essential - therapeutic use</topic><topic>Clinical Trials as Topic</topic><topic>Complement C3 - metabolism</topic><topic>Female</topic><topic>Glomerulonephritis - metabolism</topic><topic>Glomerulonephritis - therapy</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Prealbumin - metabolism</topic><topic>Protein Deficiency - prevention & control</topic><topic>Pyelonephritis - metabolism</topic><topic>Pyelonephritis - therapy</topic><topic>Renal Dialysis</topic><topic>Retinol-Binding Proteins - blood</topic><topic>Transferrin - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hecking, Erwin</creatorcontrib><creatorcontrib>Kohler, Heide</creatorcontrib><creatorcontrib>Zobel, Rainer</creatorcontrib><creatorcontrib>Lemmel, Ernst M</creatorcontrib><creatorcontrib>Mader, Hans</creatorcontrib><creatorcontrib>Opferkuch, Wolfgang</creatorcontrib><creatorcontrib>Prellwitz, Winfried</creatorcontrib><creatorcontrib>Keim, Hans J</creatorcontrib><creatorcontrib>Muller, Doris</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The American journal of clinical nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hecking, Erwin</au><au>Kohler, Heide</au><au>Zobel, Rainer</au><au>Lemmel, Ernst M</au><au>Mader, Hans</au><au>Opferkuch, Wolfgang</au><au>Prellwitz, Winfried</au><au>Keim, Hans J</au><au>Muller, Doris</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Treatment with essential amino acids in patients on chronic hemodialysis: a double blind cross-over study</atitle><jtitle>The American journal of clinical nutrition</jtitle><addtitle>Am J Clin Nutr</addtitle><date>1978-10</date><risdate>1978</risdate><volume>31</volume><issue>10</issue><spage>1821</spage><epage>1826</epage><pages>1821-1826</pages><issn>0002-9165</issn><eissn>1938-3207</eissn><abstract>Extract: Patients on chronic hemodialysis may suffer from a latent protein deficiency, and therapy with essential amino acids has been recommended. In a double blind cross-over study, 13 hemodialysis patients received orally 15.7 g of essential amino acids daily over a 3-month period. Patients were on a liberal diet, containing 1 g of protein per kilogram of body weight per day. Hemodialysis was adequate. Therapy resulted in an increase in urea, uric acid, C3 c complement factor and a fall in C4. Lysine levels increased and phenylalanine fell. Malnutrition could not account for the observed metabolic changes, which are more likely due to uremic metabolic disturbances. A liberal diet of 1 g of protein per kilogram of body weight appears sufficient for patients on hemodialysis. Treatment with essential amino acids offers no advantage</abstract><cop>United States</cop><pmid>360819</pmid><doi>10.1093/ajcn/31.10.1821</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0002-9165 |
| ispartof | The American journal of clinical nutrition, 1978-10, Vol.31 (10), p.1821-1826 |
| issn | 0002-9165 1938-3207 |
| language | eng |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Adult Amino Acids, Essential - therapeutic use Clinical Trials as Topic Complement C3 - metabolism Female Glomerulonephritis - metabolism Glomerulonephritis - therapy Humans Male Middle Aged Prealbumin - metabolism Protein Deficiency - prevention & control Pyelonephritis - metabolism Pyelonephritis - therapy Renal Dialysis Retinol-Binding Proteins - blood Transferrin - metabolism |
| title | Treatment with essential amino acids in patients on chronic hemodialysis: a double blind cross-over study |
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