Impromidine (SK&F 92676) is a very potent and specific agonist for histamine H2 receptors
PREVIOUSLY described selective agonists for histamine H 2 receptors are 4-methylhistamine 1 , related congeners 2–6 and dimaprit 7 ; these compounds are generally less potent than histamine. We have now found that N -[3-(imidazol-4-yl)-propyl]- N′ -{2-[(5-methylimidazol-4-yl) methylthio]ethyl}-guani...
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| Veröffentlicht in: | Nature (London) 1978-11, Vol.276 (5686), p.403-405 |
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| container_issue | 5686 |
| container_start_page | 403 |
| container_title | Nature (London) |
| container_volume | 276 |
| creator | DURANT, G. J. DUNCAN, W. A. M. GANELLIN, C. R. PARSONS, M. E. BLAKEMORE, R. C. RASMUSSEN, A. C. |
| description | PREVIOUSLY described selective agonists for histamine H
2
receptors are 4-methylhistamine
1
, related congeners
2–6
and dimaprit
7
; these compounds are generally less potent than histamine. We have now found that
N
-[3-(imidazol-4-yl)-propyl]-
N′
-{2-[(5-methylimidazol-4-yl) methylthio]ethyl}-guanidine (impromidine, SK&F 92676 (I)) is extremely potent as an H
2
-receptor agonist and briefly report its properties here. |
| doi_str_mv | 10.1038/276403a0 |
| format | Article |
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2
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1
, related congeners
2–6
and dimaprit
7
; these compounds are generally less potent than histamine. We have now found that
N
-[3-(imidazol-4-yl)-propyl]-
N′
-{2-[(5-methylimidazol-4-yl) methylthio]ethyl}-guanidine (impromidine, SK&F 92676 (I)) is extremely potent as an H
2
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2
receptors are 4-methylhistamine
1
, related congeners
2–6
and dimaprit
7
; these compounds are generally less potent than histamine. We have now found that
N
-[3-(imidazol-4-yl)-propyl]-
N′
-{2-[(5-methylimidazol-4-yl) methylthio]ethyl}-guanidine (impromidine, SK&F 92676 (I)) is extremely potent as an H
2
-receptor agonist and briefly report its properties here.</description><subject>Animals</subject><subject>Blood Pressure - drug effects</subject><subject>Dogs</subject><subject>Gastric Juice - metabolism</subject><subject>Guanidines - pharmacology</subject><subject>Guinea Pigs</subject><subject>Heart Rate - drug effects</subject><subject>Humanities and Social Sciences</subject><subject>Imidazoles - pharmacology</subject><subject>letter</subject><subject>multidisciplinary</subject><subject>Receptors, Histamine - drug effects</subject><subject>Receptors, Histamine H2 - drug effects</subject><subject>Science</subject><subject>Science (multidisciplinary)</subject><subject>Structure-Activity Relationship</subject><issn>0028-0836</issn><issn>1476-4687</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1978</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNplkE1LAzEYhIP4VavgD_CQU2kPq_naJHuUYm2x4EE9eFrSJFtTups12RX6702pepH3MC_Mw8AMANcY3WJE5R0RnCGq0BEYYCZ4xrgUx2CAEJEZkpSfg4sYNwihHAt2Bk4FZpjzAXhf1G3wtTOusXD88jSawYJwwSfQRajglw072PrONh1UjYGxtdpVTkO19o2LHax8gB_pUfU-YE5gsNq2nQ_xEpxUahvt1Y8Owdvs4XU6z5bPj4vp_TLTpCAoI2qlhSYVMTkhWmBcSEXwKpXS1DApebqkhTK8kDSvaG6KXHNmqMZUEUOHYHTITT0-exu7snZR2-1WNdb3sRSMEMYxT-D4AOrgYwy2KtvgahV2JUblfsTyd8SE3vxk9qvamj_wsFqyJwc7JqNZ21BufB-a1PJ_1DcAc3Yo</recordid><startdate>19781123</startdate><enddate>19781123</enddate><creator>DURANT, G. J.</creator><creator>DUNCAN, W. A. M.</creator><creator>GANELLIN, C. R.</creator><creator>PARSONS, M. E.</creator><creator>BLAKEMORE, R. C.</creator><creator>RASMUSSEN, A. C.</creator><general>Nature Publishing Group UK</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19781123</creationdate><title>Impromidine (SK&F 92676) is a very potent and specific agonist for histamine H2 receptors</title><author>DURANT, G. J. ; DUNCAN, W. A. M. ; GANELLIN, C. R. ; PARSONS, M. E. ; BLAKEMORE, R. C. ; RASMUSSEN, A. C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2920-2abc7c2f2d522c71198a21b103c3d4886868d489ad69835f35d95c64d3c13a2d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1978</creationdate><topic>Animals</topic><topic>Blood Pressure - drug effects</topic><topic>Dogs</topic><topic>Gastric Juice - metabolism</topic><topic>Guanidines - pharmacology</topic><topic>Guinea Pigs</topic><topic>Heart Rate - drug effects</topic><topic>Humanities and Social Sciences</topic><topic>Imidazoles - pharmacology</topic><topic>letter</topic><topic>multidisciplinary</topic><topic>Receptors, Histamine - drug effects</topic><topic>Receptors, Histamine H2 - drug effects</topic><topic>Science</topic><topic>Science (multidisciplinary)</topic><topic>Structure-Activity Relationship</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>DURANT, G. J.</creatorcontrib><creatorcontrib>DUNCAN, W. A. M.</creatorcontrib><creatorcontrib>GANELLIN, C. R.</creatorcontrib><creatorcontrib>PARSONS, M. E.</creatorcontrib><creatorcontrib>BLAKEMORE, R. C.</creatorcontrib><creatorcontrib>RASMUSSEN, A. C.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Nature (London)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>DURANT, G. J.</au><au>DUNCAN, W. A. M.</au><au>GANELLIN, C. R.</au><au>PARSONS, M. E.</au><au>BLAKEMORE, R. C.</au><au>RASMUSSEN, A. C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Impromidine (SK&F 92676) is a very potent and specific agonist for histamine H2 receptors</atitle><jtitle>Nature (London)</jtitle><stitle>Nature</stitle><addtitle>Nature</addtitle><date>1978-11-23</date><risdate>1978</risdate><volume>276</volume><issue>5686</issue><spage>403</spage><epage>405</epage><pages>403-405</pages><issn>0028-0836</issn><eissn>1476-4687</eissn><abstract>PREVIOUSLY described selective agonists for histamine H
2
receptors are 4-methylhistamine
1
, related congeners
2–6
and dimaprit
7
; these compounds are generally less potent than histamine. We have now found that
N
-[3-(imidazol-4-yl)-propyl]-
N′
-{2-[(5-methylimidazol-4-yl) methylthio]ethyl}-guanidine (impromidine, SK&F 92676 (I)) is extremely potent as an H
2
-receptor agonist and briefly report its properties here.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>714166</pmid><doi>10.1038/276403a0</doi><tpages>3</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0028-0836 |
| ispartof | Nature (London), 1978-11, Vol.276 (5686), p.403-405 |
| issn | 0028-0836 1476-4687 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_74224616 |
| source | MEDLINE; Nature; SpringerLink Journals - AutoHoldings |
| subjects | Animals Blood Pressure - drug effects Dogs Gastric Juice - metabolism Guanidines - pharmacology Guinea Pigs Heart Rate - drug effects Humanities and Social Sciences Imidazoles - pharmacology letter multidisciplinary Receptors, Histamine - drug effects Receptors, Histamine H2 - drug effects Science Science (multidisciplinary) Structure-Activity Relationship |
| title | Impromidine (SK&F 92676) is a very potent and specific agonist for histamine H2 receptors |
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