Effects of positive end expiratory pressure on shunt flow in atelectasis
We studied the effects of positive end expiratory pressure (PEEP) on vascular pressure flow relationships in atelectatic lobes in closed-chest pigs and compared our results to measurements we previously obtained in sublobar atelectasis. Regional hemodynamic responses to lung inflation were significa...
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| Veröffentlicht in: | Respiration physiology 1982-05, Vol.48 (2), p.243-254 |
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| container_title | Respiration physiology |
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| creator | Enjeti, Suresh O'Neill, John T. Terry, Peter B. Menkes, Harold A. Traystman, Richard J. |
| description | We studied the effects of positive end expiratory pressure (PEEP) on vascular pressure flow relationships in atelectatic lobes in closed-chest pigs and compared our results to measurements we previously obtained in sublobar atelectasis. Regional hemodynamic responses to lung inflation were significantly different between lobes and sublobar regions. PEEP caused marked increase in the fraction of cardiac output perfusing the atelectatic lobe from 16.5 ± 2.0% (SE) to 32.5 ± 2.0% at similar pulmonary vascular transmural pressures. In contrast, similar levels of PEEP failed to redistribute blood flow to the atelectatic sublobar regions. We propose that distortion of the sublobar region with inflation of the surrounding lung may be responsible for the failure of redistribution of pulmonary blood flow with application of PEEP. |
| doi_str_mv | 10.1016/0034-5687(82)90084-6 |
| format | Article |
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Regional hemodynamic responses to lung inflation were significantly different between lobes and sublobar regions. PEEP caused marked increase in the fraction of cardiac output perfusing the atelectatic lobe from 16.5 ± 2.0% (SE) to 32.5 ± 2.0% at similar pulmonary vascular transmural pressures. In contrast, similar levels of PEEP failed to redistribute blood flow to the atelectatic sublobar regions. We propose that distortion of the sublobar region with inflation of the surrounding lung may be responsible for the failure of redistribution of pulmonary blood flow with application of PEEP.</description><identifier>ISSN: 0034-5687</identifier><identifier>DOI: 10.1016/0034-5687(82)90084-6</identifier><identifier>PMID: 6750731</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Animals ; Atelectasis ; Blood pressure ; Cardiac output ; Hemodynamics ; Pig ; Positive ; Positive-Pressure Respiration ; Pulmonary Atelectasis - physiopathology ; Pulmonary Circulation ; Regional Blood Flow ; Swine</subject><ispartof>Respiration physiology, 1982-05, Vol.48 (2), p.243-254</ispartof><rights>1982</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c357t-4dec2a1e62d8eda06ef5709091c304a78f4c27e2b6f166c7027efedd38d7400a3</citedby><cites>FETCH-LOGICAL-c357t-4dec2a1e62d8eda06ef5709091c304a78f4c27e2b6f166c7027efedd38d7400a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6750731$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Enjeti, Suresh</creatorcontrib><creatorcontrib>O'Neill, John T.</creatorcontrib><creatorcontrib>Terry, Peter B.</creatorcontrib><creatorcontrib>Menkes, Harold A.</creatorcontrib><creatorcontrib>Traystman, Richard J.</creatorcontrib><title>Effects of positive end expiratory pressure on shunt flow in atelectasis</title><title>Respiration physiology</title><addtitle>Respir Physiol</addtitle><description>We studied the effects of positive end expiratory pressure (PEEP) on vascular pressure flow relationships in atelectatic lobes in closed-chest pigs and compared our results to measurements we previously obtained in sublobar atelectasis. Regional hemodynamic responses to lung inflation were significantly different between lobes and sublobar regions. PEEP caused marked increase in the fraction of cardiac output perfusing the atelectatic lobe from 16.5 ± 2.0% (SE) to 32.5 ± 2.0% at similar pulmonary vascular transmural pressures. In contrast, similar levels of PEEP failed to redistribute blood flow to the atelectatic sublobar regions. We propose that distortion of the sublobar region with inflation of the surrounding lung may be responsible for the failure of redistribution of pulmonary blood flow with application of PEEP.</description><subject>Animals</subject><subject>Atelectasis</subject><subject>Blood pressure</subject><subject>Cardiac output</subject><subject>Hemodynamics</subject><subject>Pig</subject><subject>Positive</subject><subject>Positive-Pressure Respiration</subject><subject>Pulmonary Atelectasis - physiopathology</subject><subject>Pulmonary Circulation</subject><subject>Regional Blood Flow</subject><subject>Swine</subject><issn>0034-5687</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1982</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kDFPwzAQhT2ASin8A5A8IRgC58Sx0wUJVYUiVWKB2XLtszBK42Anhf57UloxMp3e3b13uo-QCwa3DJi4Ayh4VopKXlf5zRSg4pk4IuO_9gk5TekDBi1AjMhIyBJkwcZkMXcOTZdocLQNyXd-gxQbS_G79VF3IW5pGzGlPiINDU3vfdNRV4cv6huqO6wHt04-nZFjp-uE54c6IW-P89fZIlu-PD3PHpaZKUrZZdyiyTVDkdsKrQaBrpQwhSkzBXAtK8dNLjFfCceEMBIG4dDaorKSA-hiQq72uW0Mnz2mTq19MljXusHQJyV5nnMmYVjk-0UTQ0oRnWqjX-u4VQzUDpra0VE7OqrK1S80JQbb5SG_X63R_pkOxIb5_X6Ow5Mbj1El47ExaH0cUCgb_P8HfgASPH4V</recordid><startdate>198205</startdate><enddate>198205</enddate><creator>Enjeti, Suresh</creator><creator>O'Neill, John T.</creator><creator>Terry, Peter B.</creator><creator>Menkes, Harold A.</creator><creator>Traystman, Richard J.</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198205</creationdate><title>Effects of positive end expiratory pressure on shunt flow in atelectasis</title><author>Enjeti, Suresh ; O'Neill, John T. ; Terry, Peter B. ; Menkes, Harold A. ; Traystman, Richard J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c357t-4dec2a1e62d8eda06ef5709091c304a78f4c27e2b6f166c7027efedd38d7400a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1982</creationdate><topic>Animals</topic><topic>Atelectasis</topic><topic>Blood pressure</topic><topic>Cardiac output</topic><topic>Hemodynamics</topic><topic>Pig</topic><topic>Positive</topic><topic>Positive-Pressure Respiration</topic><topic>Pulmonary Atelectasis - physiopathology</topic><topic>Pulmonary Circulation</topic><topic>Regional Blood Flow</topic><topic>Swine</topic><toplevel>online_resources</toplevel><creatorcontrib>Enjeti, Suresh</creatorcontrib><creatorcontrib>O'Neill, John T.</creatorcontrib><creatorcontrib>Terry, Peter B.</creatorcontrib><creatorcontrib>Menkes, Harold A.</creatorcontrib><creatorcontrib>Traystman, Richard J.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Respiration physiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Enjeti, Suresh</au><au>O'Neill, John T.</au><au>Terry, Peter B.</au><au>Menkes, Harold A.</au><au>Traystman, Richard J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of positive end expiratory pressure on shunt flow in atelectasis</atitle><jtitle>Respiration physiology</jtitle><addtitle>Respir Physiol</addtitle><date>1982-05</date><risdate>1982</risdate><volume>48</volume><issue>2</issue><spage>243</spage><epage>254</epage><pages>243-254</pages><issn>0034-5687</issn><abstract>We studied the effects of positive end expiratory pressure (PEEP) on vascular pressure flow relationships in atelectatic lobes in closed-chest pigs and compared our results to measurements we previously obtained in sublobar atelectasis. 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| subjects | Animals Atelectasis Blood pressure Cardiac output Hemodynamics Pig Positive Positive-Pressure Respiration Pulmonary Atelectasis - physiopathology Pulmonary Circulation Regional Blood Flow Swine |
| title | Effects of positive end expiratory pressure on shunt flow in atelectasis |
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