ESTRADIOL 17β-SULFATE AS A SUBSTRATE FOR 2-HYDROXYLATION ENZYME OF RAT LIVER MICROSOMES (CLINICAL ANALYSIS ON STEROIDS. XX)

4-14C-Estradiol and its 17β-sulfate were incubated with rat liver microsomes under NADPH-generating system. Estradiol in liver microsomes from male and female rats was metabolized to multiple kinds of oxidized products including estrone, 2-hydroxyestrone, 2-hydroxyestradiol, and other minor steroids...

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Veröffentlicht in:	Journal of Pharmacobio-Dynamics 1982, Vol.5(5), pp.340-347
Hauptverfasser:	WATANABE, KAZUHIRO, YOSHIZAWA, ITSUO
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Chromatography, Thin Layer Cytochrome P-450 CYP1A1 Estradiol - metabolism In Vitro Techniques Microsomes, Liver - enzymology Rats Rats, Inbred Strains sexual difference Steroid Hydroxylases - metabolism
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