MECHANISM OF NATURAL RESISTANCE OF RAT ASCITES HEPATOMAS TO 1-β-D-ARABINOFURANOSYLCYTOSINE

The biochemical basis for natural resistance to 1-β-D-arabinofuranosylcytosine (ara-C) was investigated in the intact cells of 4 rat ascites hepatomas, AH-66F, AH-60C, AH-109A, and AH-66, whose sensitivity to ara-C was different in that decreasing order. The initial rapid uptake of ara-C, mediated b...

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Veröffentlicht in:	GANN Japanese Journal of Cancer Research 1978/08/31, Vol.69(4), pp.557-564
Hauptverfasser:	ABE, Ikuo, SATO, Shojiro, WATANABE, Minro, SATO, Haruo
Format:	Artikel
Sprache:	eng
Schlagworte:	1-β-D-Arabinofuranosylcytosine Animals Ascites heaptoma Chemotherapy, experimental Cytarabine - metabolism Cytarabine - therapeutic use Leukemia L1210 - metabolism Liver Neoplasms, Experimental - drug therapy Liver Neoplasms, Experimental - metabolism Male Mice Natural resistance Phosphorylation Rat Rats
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