Acquired antithrombin III deficiency and thrombosis in the nephrotic syndrome
Antithrombin III levels were studied in relation to the occurrence of thromboembolism in 48 patients with various degrees of proteinuria. Nine of these patients had clinical signs of thrombosis, including four with renal vein thrombosis. In eight of these nine patients, antithrombin III concentratio...
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| Veröffentlicht in: | The American journal of medicine 1978-10, Vol.65 (4), p.607-613 |
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| container_title | The American journal of medicine |
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| creator | Kauffmann, Robert H. Veltkamp, Jan J. Van Tilburg, Nico H. Van Es, Leendert A. |
| description | Antithrombin III levels were studied in relation to the occurrence of thromboembolism in 48 patients with various degrees of proteinuria. Nine of these patients had clinical signs of thrombosis, including four with renal vein thrombosis. In eight of these nine patients, antithrombin III concentrations were below 70 per cent. There was a significant negative correlation between the antithrombin III concentration and the urinary protein excretion (P < 0.001). Antithrombin III was found in the urine of 32 of 42 patients. There was a significant correlation between the renal clearance and the degree of antithrombin III serum deficiency (P < 0.001). The clearance and serum level of albumin closely paralleled these changes. We conclude that thrombosis in patients with severe proteinuria is associated with a deficiency of antithrombin III due to urinary excretion of this protein. |
| doi_str_mv | 10.1016/0002-9343(78)90848-3 |
| format | Article |
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Nine of these patients had clinical signs of thrombosis, including four with renal vein thrombosis. In eight of these nine patients, antithrombin III concentrations were below 70 per cent. There was a significant negative correlation between the antithrombin III concentration and the urinary protein excretion (P < 0.001). Antithrombin III was found in the urine of 32 of 42 patients. There was a significant correlation between the renal clearance and the degree of antithrombin III serum deficiency (P < 0.001). The clearance and serum level of albumin closely paralleled these changes. We conclude that thrombosis in patients with severe proteinuria is associated with a deficiency of antithrombin III due to urinary excretion of this protein.</description><identifier>ISSN: 0002-9343</identifier><identifier>EISSN: 1555-7162</identifier><identifier>DOI: 10.1016/0002-9343(78)90848-3</identifier><identifier>PMID: 707521</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adolescent ; Adult ; Aged ; Antithrombin III Deficiency ; Female ; Humans ; Kidney Diseases - blood ; Kidney Diseases - complications ; Kidney Diseases - urine ; Male ; Middle Aged ; Nephrotic Syndrome - blood ; Nephrotic Syndrome - complications ; Nephrotic Syndrome - urine ; Proteinuria ; Serum Albumin - analysis ; Thromboembolism - blood ; Thromboembolism - complications</subject><ispartof>The American journal of medicine, 1978-10, Vol.65 (4), p.607-613</ispartof><rights>1978</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c337t-551399efb14cf0474ec55901c3a5a275eb0d8baea310d1b6c14724f1e3f9e4413</citedby><cites>FETCH-LOGICAL-c337t-551399efb14cf0474ec55901c3a5a275eb0d8baea310d1b6c14724f1e3f9e4413</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0002-9343(78)90848-3$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,781,785,3551,27928,27929,45999</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/707521$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kauffmann, Robert H.</creatorcontrib><creatorcontrib>Veltkamp, Jan J.</creatorcontrib><creatorcontrib>Van Tilburg, Nico H.</creatorcontrib><creatorcontrib>Van Es, Leendert A.</creatorcontrib><title>Acquired antithrombin III deficiency and thrombosis in the nephrotic syndrome</title><title>The American journal of medicine</title><addtitle>Am J Med</addtitle><description>Antithrombin III levels were studied in relation to the occurrence of thromboembolism in 48 patients with various degrees of proteinuria. Nine of these patients had clinical signs of thrombosis, including four with renal vein thrombosis. In eight of these nine patients, antithrombin III concentrations were below 70 per cent. There was a significant negative correlation between the antithrombin III concentration and the urinary protein excretion (P < 0.001). Antithrombin III was found in the urine of 32 of 42 patients. There was a significant correlation between the renal clearance and the degree of antithrombin III serum deficiency (P < 0.001). The clearance and serum level of albumin closely paralleled these changes. We conclude that thrombosis in patients with severe proteinuria is associated with a deficiency of antithrombin III due to urinary excretion of this protein.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Antithrombin III Deficiency</subject><subject>Female</subject><subject>Humans</subject><subject>Kidney Diseases - blood</subject><subject>Kidney Diseases - complications</subject><subject>Kidney Diseases - urine</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Nephrotic Syndrome - blood</subject><subject>Nephrotic Syndrome - complications</subject><subject>Nephrotic Syndrome - urine</subject><subject>Proteinuria</subject><subject>Serum Albumin - analysis</subject><subject>Thromboembolism - blood</subject><subject>Thromboembolism - complications</subject><issn>0002-9343</issn><issn>1555-7162</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1978</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMtOwzAQRS3EqxT-oIusECwCntiOkw1SVfGIVMQG1pZjT1SjJmnjBKl_j9tULFmNPOfOlXwImQF9AArpI6U0iXPG2Z3M7nOa8SxmJ2QCQohYQpqckslf5JJcef8dnjQX6QU5l1SKBCbkfW62g-vQRrrpXb_q2rp0TVQURWSxcsZhY3aB2WhkrXc-CoF-hVGDm7DrnYn8rrGB4jU5q_Ta481xTsnXy_Pn4i1efrwWi_kyNozJPhYCWJ5jVQI3FeWSoxEip2CYFjqRAktqs1KjZkAtlKkBLhNeAbIqR86BTcnt2Lvp2u2Avle18wbXa91gO3gleQKMCRqCfAyarvW-w0ptOlfrbqeAqr1EtTek9oaUzNRBomLhbHbsH8oa7d_RaC3gpxFj-OOPw075gyi0waTplW3d__2_nUSAnw</recordid><startdate>197810</startdate><enddate>197810</enddate><creator>Kauffmann, Robert H.</creator><creator>Veltkamp, Jan J.</creator><creator>Van Tilburg, Nico H.</creator><creator>Van Es, Leendert A.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>197810</creationdate><title>Acquired antithrombin III deficiency and thrombosis in the nephrotic syndrome</title><author>Kauffmann, Robert H. ; Veltkamp, Jan J. ; Van Tilburg, Nico H. ; Van Es, Leendert A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c337t-551399efb14cf0474ec55901c3a5a275eb0d8baea310d1b6c14724f1e3f9e4413</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1978</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Antithrombin III Deficiency</topic><topic>Female</topic><topic>Humans</topic><topic>Kidney Diseases - blood</topic><topic>Kidney Diseases - complications</topic><topic>Kidney Diseases - urine</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Nephrotic Syndrome - blood</topic><topic>Nephrotic Syndrome - complications</topic><topic>Nephrotic Syndrome - urine</topic><topic>Proteinuria</topic><topic>Serum Albumin - analysis</topic><topic>Thromboembolism - blood</topic><topic>Thromboembolism - complications</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kauffmann, Robert H.</creatorcontrib><creatorcontrib>Veltkamp, Jan J.</creatorcontrib><creatorcontrib>Van Tilburg, Nico H.</creatorcontrib><creatorcontrib>Van Es, Leendert A.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The American journal of medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kauffmann, Robert H.</au><au>Veltkamp, Jan J.</au><au>Van Tilburg, Nico H.</au><au>Van Es, Leendert A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Acquired antithrombin III deficiency and thrombosis in the nephrotic syndrome</atitle><jtitle>The American journal of medicine</jtitle><addtitle>Am J Med</addtitle><date>1978-10</date><risdate>1978</risdate><volume>65</volume><issue>4</issue><spage>607</spage><epage>613</epage><pages>607-613</pages><issn>0002-9343</issn><eissn>1555-7162</eissn><abstract>Antithrombin III levels were studied in relation to the occurrence of thromboembolism in 48 patients with various degrees of proteinuria. Nine of these patients had clinical signs of thrombosis, including four with renal vein thrombosis. In eight of these nine patients, antithrombin III concentrations were below 70 per cent. There was a significant negative correlation between the antithrombin III concentration and the urinary protein excretion (P < 0.001). Antithrombin III was found in the urine of 32 of 42 patients. There was a significant correlation between the renal clearance and the degree of antithrombin III serum deficiency (P < 0.001). The clearance and serum level of albumin closely paralleled these changes. We conclude that thrombosis in patients with severe proteinuria is associated with a deficiency of antithrombin III due to urinary excretion of this protein.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>707521</pmid><doi>10.1016/0002-9343(78)90848-3</doi><tpages>7</tpages></addata></record> |
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| ispartof | The American journal of medicine, 1978-10, Vol.65 (4), p.607-613 |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Adolescent Adult Aged Antithrombin III Deficiency Female Humans Kidney Diseases - blood Kidney Diseases - complications Kidney Diseases - urine Male Middle Aged Nephrotic Syndrome - blood Nephrotic Syndrome - complications Nephrotic Syndrome - urine Proteinuria Serum Albumin - analysis Thromboembolism - blood Thromboembolism - complications |
| title | Acquired antithrombin III deficiency and thrombosis in the nephrotic syndrome |
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