The effect of heparin on the activated partial thromboplastin time
Data from the 1976 and 1977 CAP surveys were analyzed for response of the activated partial thromboplastin time (APTT) to heparin. Different sources and concentrations of heparin were used. The results indicate that the precision of the APTT is more dependent on instrumentation than on partial throm...
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| Veröffentlicht in: | American journal of clinical pathology 1978-09, Vol.70 (3 Suppl), p.556-559 |
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| container_end_page | 559 |
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| container_issue | 3 Suppl |
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| container_title | American journal of clinical pathology |
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| creator | Triplett, D A Harms, C S Koepke, J A |
| description | Data from the 1976 and 1977 CAP surveys were analyzed for response of the activated partial thromboplastin time (APTT) to heparin. Different sources and concentrations of heparin were used. The results indicate that the precision of the APTT is more dependent on instrumentation than on partial thromboplastin. This was true for all four of the heparinized specimens evaluated. A single exception was found with the "old" Dade reagent activated cephaloplastin. The mean difference in the activated partial thromboplastin times obtained with differing concentrations of heparin was entirely dependent on the partial thromboplastin reagent used. No significant difference in the results was found when equal concentrations of bovine lung and porcine intestinal mucosal heparin were compared. |
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Different sources and concentrations of heparin were used. The results indicate that the precision of the APTT is more dependent on instrumentation than on partial thromboplastin. This was true for all four of the heparinized specimens evaluated. A single exception was found with the "old" Dade reagent activated cephaloplastin. The mean difference in the activated partial thromboplastin times obtained with differing concentrations of heparin was entirely dependent on the partial thromboplastin reagent used. No significant difference in the results was found when equal concentrations of bovine lung and porcine intestinal mucosal heparin were compared.</description><identifier>ISSN: 0002-9173</identifier><identifier>PMID: 568381</identifier><language>eng</language><publisher>England</publisher><subject>Animals ; Blood Coagulation Tests - methods ; Cattle ; Evaluation Studies as Topic ; Heparin - pharmacology ; Heparin - standards ; Humans ; Indicators and Reagents - standards ; Intestinal Mucosa ; Laboratories - standards ; Lung ; Pathology ; Societies, Medical ; Swine ; Thromboplastin - physiology ; Thromboplastin - standards ; United States</subject><ispartof>American journal of clinical pathology, 1978-09, Vol.70 (3 Suppl), p.556-559</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/568381$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Triplett, D A</creatorcontrib><creatorcontrib>Harms, C S</creatorcontrib><creatorcontrib>Koepke, J A</creatorcontrib><title>The effect of heparin on the activated partial thromboplastin time</title><title>American journal of clinical pathology</title><addtitle>Am J Clin Pathol</addtitle><description>Data from the 1976 and 1977 CAP surveys were analyzed for response of the activated partial thromboplastin time (APTT) to heparin. Different sources and concentrations of heparin were used. The results indicate that the precision of the APTT is more dependent on instrumentation than on partial thromboplastin. This was true for all four of the heparinized specimens evaluated. A single exception was found with the "old" Dade reagent activated cephaloplastin. The mean difference in the activated partial thromboplastin times obtained with differing concentrations of heparin was entirely dependent on the partial thromboplastin reagent used. No significant difference in the results was found when equal concentrations of bovine lung and porcine intestinal mucosal heparin were compared.</description><subject>Animals</subject><subject>Blood Coagulation Tests - methods</subject><subject>Cattle</subject><subject>Evaluation Studies as Topic</subject><subject>Heparin - pharmacology</subject><subject>Heparin - standards</subject><subject>Humans</subject><subject>Indicators and Reagents - standards</subject><subject>Intestinal Mucosa</subject><subject>Laboratories - standards</subject><subject>Lung</subject><subject>Pathology</subject><subject>Societies, Medical</subject><subject>Swine</subject><subject>Thromboplastin - physiology</subject><subject>Thromboplastin - standards</subject><subject>United States</subject><issn>0002-9173</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1978</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNotj7tqxDAURFXktdnkD1KoSmfQw7LkMlnygoU0m9pc-16xCrblWHIgfx_DbjVw5jAwF2wjhFBFLa2-YbcpfQshlRPlNbsyldNObtjz4UicvKcu8-j5kSaYw8jjyPNaQJfDL2RCvuIcoF_pHIc2Tj2kvHo5DHTHLj30ie7PuWVfry-H3Xux_3z72D3ti0kJkws0xlVSSGuFlm3nXW2MBuuh7NAoLci5mlBahVY7ItSoK2yxrbGEGi3qLXs87U5z_Fko5WYIqaO-h5HikhpbKqmkKVfx4Swu7UDYTHMYYP5rTp_1Px76Uaw</recordid><startdate>197809</startdate><enddate>197809</enddate><creator>Triplett, D A</creator><creator>Harms, C S</creator><creator>Koepke, J A</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>197809</creationdate><title>The effect of heparin on the activated partial thromboplastin time</title><author>Triplett, D A ; Harms, C S ; Koepke, J A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p205t-d558610177031bcf89553a7fa4cd5230e889ed172d738eed3d36dbdb9d4a9d7d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1978</creationdate><topic>Animals</topic><topic>Blood Coagulation Tests - methods</topic><topic>Cattle</topic><topic>Evaluation Studies as Topic</topic><topic>Heparin - pharmacology</topic><topic>Heparin - standards</topic><topic>Humans</topic><topic>Indicators and Reagents - standards</topic><topic>Intestinal Mucosa</topic><topic>Laboratories - standards</topic><topic>Lung</topic><topic>Pathology</topic><topic>Societies, Medical</topic><topic>Swine</topic><topic>Thromboplastin - physiology</topic><topic>Thromboplastin - standards</topic><topic>United States</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Triplett, D A</creatorcontrib><creatorcontrib>Harms, C S</creatorcontrib><creatorcontrib>Koepke, J A</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of clinical pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Triplett, D A</au><au>Harms, C S</au><au>Koepke, J A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The effect of heparin on the activated partial thromboplastin time</atitle><jtitle>American journal of clinical pathology</jtitle><addtitle>Am J Clin Pathol</addtitle><date>1978-09</date><risdate>1978</risdate><volume>70</volume><issue>3 Suppl</issue><spage>556</spage><epage>559</epage><pages>556-559</pages><issn>0002-9173</issn><abstract>Data from the 1976 and 1977 CAP surveys were analyzed for response of the activated partial thromboplastin time (APTT) to heparin. Different sources and concentrations of heparin were used. The results indicate that the precision of the APTT is more dependent on instrumentation than on partial thromboplastin. This was true for all four of the heparinized specimens evaluated. A single exception was found with the "old" Dade reagent activated cephaloplastin. The mean difference in the activated partial thromboplastin times obtained with differing concentrations of heparin was entirely dependent on the partial thromboplastin reagent used. No significant difference in the results was found when equal concentrations of bovine lung and porcine intestinal mucosal heparin were compared.</abstract><cop>England</cop><pmid>568381</pmid><tpages>4</tpages></addata></record> |
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| ispartof | American journal of clinical pathology, 1978-09, Vol.70 (3 Suppl), p.556-559 |
| issn | 0002-9173 |
| language | eng |
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| source | MEDLINE; Oxford University Press Journals Digital Archive Legacy |
| subjects | Animals Blood Coagulation Tests - methods Cattle Evaluation Studies as Topic Heparin - pharmacology Heparin - standards Humans Indicators and Reagents - standards Intestinal Mucosa Laboratories - standards Lung Pathology Societies, Medical Swine Thromboplastin - physiology Thromboplastin - standards United States |
| title | The effect of heparin on the activated partial thromboplastin time |
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