A study on the labeling of o-iodohippuric acid with 123I
Recent emphasis on the replacement of 131I with 123I, in the ionic form and incorporated into organ and function specific compounds, prompted an investigation of the radioiodination of the renal function and imaging agent, o-iodohippuric acid. One of the more rapid and efficient methods is one in wh...
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| Veröffentlicht in: | The International journal of applied radiation and isotopes 1978-07, Vol.29 (7), p.449-451 |
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| container_end_page | 451 |
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| container_issue | 7 |
| container_start_page | 449 |
| container_title | The International journal of applied radiation and isotopes |
| container_volume | 29 |
| creator | Fortman, Donald L. Robbins, Philip J. Sodd, Vincent J. |
| description | Recent emphasis on the replacement of
131I with
123I, in the ionic form and incorporated into organ and function specific compounds, prompted an investigation of the radioiodination of the renal function and imaging agent,
o-iodohippuric acid. One of the more rapid and efficient methods is one in which the
o-iodohippuric acid, in the molten state, is labeled with
123I. The effects of volume and chemical composition of
123I solutions on the labeling efficiency of this “melt” method were determined. The results showed that a concentration of NaOH greater than 0.6 molecular equivalent (meq) per 200 mg of
o-iodohippuric acid caused a rapid decrease in labeling efficiency resulting from a change in the pH of the reaction mixture from acidic to basic. Adjustment of the pH to below approximately 5 before the reaction resulted in quantitative labeling yields. When the
123I was in saline, the yield was independent of the volume of saline. As a result of these studies, a method for fast and efficient labeling of
o-iodohippuric acid with
123I was developed and is described. |
| doi_str_mv | 10.1016/0020-708X(78)90082-0 |
| format | Article |
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131I with
123I, in the ionic form and incorporated into organ and function specific compounds, prompted an investigation of the radioiodination of the renal function and imaging agent,
o-iodohippuric acid. One of the more rapid and efficient methods is one in which the
o-iodohippuric acid, in the molten state, is labeled with
123I. The effects of volume and chemical composition of
123I solutions on the labeling efficiency of this “melt” method were determined. The results showed that a concentration of NaOH greater than 0.6 molecular equivalent (meq) per 200 mg of
o-iodohippuric acid caused a rapid decrease in labeling efficiency resulting from a change in the pH of the reaction mixture from acidic to basic. Adjustment of the pH to below approximately 5 before the reaction resulted in quantitative labeling yields. When the
123I was in saline, the yield was independent of the volume of saline. As a result of these studies, a method for fast and efficient labeling of
o-iodohippuric acid with
123I was developed and is described.</description><identifier>ISSN: 0020-708X</identifier><identifier>DOI: 10.1016/0020-708X(78)90082-0</identifier><identifier>PMID: 711352</identifier><language>eng</language><publisher>United States: Elsevier B.V</publisher><subject>Costs and Cost Analysis ; Iodine Radioisotopes ; Iodohippuric Acid ; Isotope Labeling - economics ; Isotope Labeling - methods</subject><ispartof>The International journal of applied radiation and isotopes, 1978-07, Vol.29 (7), p.449-451</ispartof><rights>1978</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2032-b9bae642691547daa1d20f7356afbc0aecd05f01bb9ace3cce1f81ce6e04a253</citedby><cites>FETCH-LOGICAL-c2032-b9bae642691547daa1d20f7356afbc0aecd05f01bb9ace3cce1f81ce6e04a253</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/711352$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fortman, Donald L.</creatorcontrib><creatorcontrib>Robbins, Philip J.</creatorcontrib><creatorcontrib>Sodd, Vincent J.</creatorcontrib><title>A study on the labeling of o-iodohippuric acid with 123I</title><title>The International journal of applied radiation and isotopes</title><addtitle>Int J Appl Radiat Isot</addtitle><description>Recent emphasis on the replacement of
131I with
123I, in the ionic form and incorporated into organ and function specific compounds, prompted an investigation of the radioiodination of the renal function and imaging agent,
o-iodohippuric acid. One of the more rapid and efficient methods is one in which the
o-iodohippuric acid, in the molten state, is labeled with
123I. The effects of volume and chemical composition of
123I solutions on the labeling efficiency of this “melt” method were determined. The results showed that a concentration of NaOH greater than 0.6 molecular equivalent (meq) per 200 mg of
o-iodohippuric acid caused a rapid decrease in labeling efficiency resulting from a change in the pH of the reaction mixture from acidic to basic. Adjustment of the pH to below approximately 5 before the reaction resulted in quantitative labeling yields. When the
123I was in saline, the yield was independent of the volume of saline. As a result of these studies, a method for fast and efficient labeling of
o-iodohippuric acid with
123I was developed and is described.</description><subject>Costs and Cost Analysis</subject><subject>Iodine Radioisotopes</subject><subject>Iodohippuric Acid</subject><subject>Isotope Labeling - economics</subject><subject>Isotope Labeling - methods</subject><issn>0020-708X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1978</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kDtPwzAQxz3wKoVv0METgiFwdh5OFqSq4lGpEksHNsuxL9QojYOdgPrtSUnVkel0939I9yNkxuCeAcseADhEAvL3W5HfFQA5j-CETI7nC3IZwuew8iLLz8mZYCxO-YTkcxq63uyoa2i3QVqrEmvbfFBXURdZZ9zGtm3vraZKW0N_bLehjMfLK3JaqTrg9WFOyfr5ab14jVZvL8vFfBVpDjGPyqJUmCU8K1iaCKMUMxwqEaeZqkoNCrWBtAJWloXSGGuNrMqZxgwhUTyNp-RmrG29--oxdHJrg8a6Vg26PkiRcEhTwQdjMhq1dyF4rGTr7Vb5nWQg94jknoXcs5Ail3-IJAyx2aG_L7dojqGRzyA_jjIOL35b9DJoi41GYz3qThpn_-__BQPFdm0</recordid><startdate>197807</startdate><enddate>197807</enddate><creator>Fortman, Donald L.</creator><creator>Robbins, Philip J.</creator><creator>Sodd, Vincent J.</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>197807</creationdate><title>A study on the labeling of o-iodohippuric acid with 123I</title><author>Fortman, Donald L. ; Robbins, Philip J. ; Sodd, Vincent J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2032-b9bae642691547daa1d20f7356afbc0aecd05f01bb9ace3cce1f81ce6e04a253</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1978</creationdate><topic>Costs and Cost Analysis</topic><topic>Iodine Radioisotopes</topic><topic>Iodohippuric Acid</topic><topic>Isotope Labeling - economics</topic><topic>Isotope Labeling - methods</topic><toplevel>online_resources</toplevel><creatorcontrib>Fortman, Donald L.</creatorcontrib><creatorcontrib>Robbins, Philip J.</creatorcontrib><creatorcontrib>Sodd, Vincent J.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The International journal of applied radiation and isotopes</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fortman, Donald L.</au><au>Robbins, Philip J.</au><au>Sodd, Vincent J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A study on the labeling of o-iodohippuric acid with 123I</atitle><jtitle>The International journal of applied radiation and isotopes</jtitle><addtitle>Int J Appl Radiat Isot</addtitle><date>1978-07</date><risdate>1978</risdate><volume>29</volume><issue>7</issue><spage>449</spage><epage>451</epage><pages>449-451</pages><issn>0020-708X</issn><abstract>Recent emphasis on the replacement of
131I with
123I, in the ionic form and incorporated into organ and function specific compounds, prompted an investigation of the radioiodination of the renal function and imaging agent,
o-iodohippuric acid. One of the more rapid and efficient methods is one in which the
o-iodohippuric acid, in the molten state, is labeled with
123I. The effects of volume and chemical composition of
123I solutions on the labeling efficiency of this “melt” method were determined. The results showed that a concentration of NaOH greater than 0.6 molecular equivalent (meq) per 200 mg of
o-iodohippuric acid caused a rapid decrease in labeling efficiency resulting from a change in the pH of the reaction mixture from acidic to basic. Adjustment of the pH to below approximately 5 before the reaction resulted in quantitative labeling yields. When the
123I was in saline, the yield was independent of the volume of saline. As a result of these studies, a method for fast and efficient labeling of
o-iodohippuric acid with
123I was developed and is described.</abstract><cop>United States</cop><pub>Elsevier B.V</pub><pmid>711352</pmid><doi>10.1016/0020-708X(78)90082-0</doi><tpages>3</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0020-708X |
| ispartof | The International journal of applied radiation and isotopes, 1978-07, Vol.29 (7), p.449-451 |
| issn | 0020-708X |
| language | eng |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Costs and Cost Analysis Iodine Radioisotopes Iodohippuric Acid Isotope Labeling - economics Isotope Labeling - methods |
| title | A study on the labeling of o-iodohippuric acid with 123I |
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