Subacute Hepatic Failure: Is It a Distinct Entity?

We prospectively studied patients with subacute hepatic failure due to subacute hepatitis to find out 1) its relative prevalence compared to acute liver failure due to fulminant hepatitis and chronic liver failure due to chronic active hepatitis; 2) its clinical, biochemical, and morphological chara...

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Veröffentlicht in:Journal of clinical gastroenterology 1982-08, Vol.4 (4), p.343-346
Hauptverfasser: Tandon, B N, Joshi, Y K, Krishnamurthy, L, Tandon, H D
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container_end_page 346
container_issue 4
container_start_page 343
container_title Journal of clinical gastroenterology
container_volume 4
creator Tandon, B N
Joshi, Y K
Krishnamurthy, L
Tandon, H D
description We prospectively studied patients with subacute hepatic failure due to subacute hepatitis to find out 1) its relative prevalence compared to acute liver failure due to fulminant hepatitis and chronic liver failure due to chronic active hepatitis; 2) its clinical, biochemical, and morphological characteristics; 3) the role of virus B in its etiology; and 4) its prognosis and whether there were any predictors of bad prognosis.Thirty-three patients with subacute hepatic failure were registered during a 3-year period. Persistent or progressively deepening jaundice of 8 weeks duration and development of moderate to severe ascites in patients starting otherwise with typical features of acute viral hepatitis, defined the subacute hepatic failure group. The characteristic features included moderate to deep icterus, ascites, and peripheral edema; encephalopathy and gastrointestinal bleeding were infrequent. Liver function tests were abnormal but not diagnostic. Submassive and bridging necrosis of the liver were the main histological findings. Virus B etiology was recorded in 42% of the patients. Mortality was 66%. This condition is highly fatal and not infrequent in India.
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Persistent or progressively deepening jaundice of 8 weeks duration and development of moderate to severe ascites in patients starting otherwise with typical features of acute viral hepatitis, defined the subacute hepatic failure group. The characteristic features included moderate to deep icterus, ascites, and peripheral edema; encephalopathy and gastrointestinal bleeding were infrequent. Liver function tests were abnormal but not diagnostic. Submassive and bridging necrosis of the liver were the main histological findings. Virus B etiology was recorded in 42% of the patients. Mortality was 66%. 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Persistent or progressively deepening jaundice of 8 weeks duration and development of moderate to severe ascites in patients starting otherwise with typical features of acute viral hepatitis, defined the subacute hepatic failure group. The characteristic features included moderate to deep icterus, ascites, and peripheral edema; encephalopathy and gastrointestinal bleeding were infrequent. Liver function tests were abnormal but not diagnostic. Submassive and bridging necrosis of the liver were the main histological findings. Virus B etiology was recorded in 42% of the patients. Mortality was 66%. 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source MEDLINE; Journals@Ovid Complete
subjects Adolescent
Aged
Child
Child, Preschool
Female
Hepatitis B - complications
Hepatitis B - pathology
Hepatitis B Surface Antigens - analysis
Hepatitis, Viral, Human - complications
Hepatitis, Viral, Human - pathology
Humans
Infant
Infant, Newborn
Liver - pathology
Liver Diseases - etiology
Liver Diseases - pathology
Liver Function Tests
Male
Middle Aged
Necrosis
Prognosis
Prospective Studies
title Subacute Hepatic Failure: Is It a Distinct Entity?
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