Side chain characteristic main chain conformations of amino acid residues
Main chain conformation characteristics of the respective side chains of the 20 naturally occurring amino acid residues were obtained by the analysis of (φ, ε)‐data from the crystal structures of 38 different globular proteins. The following observations are of interest: (i) For amino acids other th...
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| Veröffentlicht in: | International Journal of Peptide and Protein Research 1982-01, Vol.19 (1), p.1-9 |
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| creator | KOLASKAR, A.S. RAMABRAHMAM, V. |
| description | Main chain conformation characteristics of the respective side chains of the 20 naturally occurring amino acid residues were obtained by the analysis of (φ, ε)‐data from the crystal structures of 38 different globular proteins. The following observations are of interest: (i) For amino acids other than Glu, Thr and aliphatic amino acids, at least one main chain conformation is stabilised solely by side chain atoms. Such conformations are listed. (ii) In globular proteins, the main chain conformations which are significantly destabilised by side chain atom interactions are observed. The stabilising force for those conformations seems to come from main chain atom interactions. (iii) A set of conformations for which the main chain and side chain interactions are almost equal but in opposite directions, is listed and these conformations will be taken by residues mainly due to the effect of surroundings.
The results can be used to study the folding of polypeptide chains and they also provide an insight into the role of the respective side chains on main chain conformations of amino acid residues. |
| doi_str_mv | 10.1111/j.1399-3011.1982.tb03016.x |
| format | Article |
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The results can be used to study the folding of polypeptide chains and they also provide an insight into the role of the respective side chains on main chain conformations of amino acid residues.</description><subject>Amino Acids</subject><subject>Crystallography</subject><subject>data analysis</subject><subject>Probability</subject><subject>Protein Conformation</subject><subject>protein crystal structure</subject><subject>side chain specificity of amino acid residues</subject><issn>0367-8377</issn><issn>1399-3011</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1982</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkE1PwzAMhiMEgvHxE5AqDtxa4iZpWiQOMGBMQ4BgEtyiLElFxtqOpBPj35Nq1e74YMt-_drSg9AZ4ARCXMwTIEUREwyQQJGnSTvDocmS9Q4abKVdNMAk43FOOD9Ah97PMSaU8HQf7XOAMC4GaPxmtYnUp7R1l51UrXHWt1ZFVT_rclOXjatka5vaR00ZycrWTSSV1ZEz3uqV8cdor5QLb076eoSm93fT4UP8-DwaD68fY0VxBjFjqdI5ppRhxXJDMZ4xCVjTQoNihs0KzVgOplRMFiklUDJdcqpzCoowSY7Q-ebs0jXf4W0rKuuVWSxkbZqVF5ymGPKMhsXLzaJyjffOlGLpbCXdrwAsOoxiLjpWomMlOoyixyjWwXzaf1nNKqO31p5b0K82-o9dmN9_XBbDm9tbCP544w-ozXrrl-5LZJxwJt6fRuLh_mXyQV8zMSF_9LiQ8Q</recordid><startdate>198201</startdate><enddate>198201</enddate><creator>KOLASKAR, A.S.</creator><creator>RAMABRAHMAM, V.</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198201</creationdate><title>Side chain characteristic main chain conformations of amino acid residues</title><author>KOLASKAR, A.S. ; RAMABRAHMAM, V.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4061-552cd804450c58e400b5a10d49d1c5e5b9d5581efc5a92431f5df74d841c35a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1982</creationdate><topic>Amino Acids</topic><topic>Crystallography</topic><topic>data analysis</topic><topic>Probability</topic><topic>Protein Conformation</topic><topic>protein crystal structure</topic><topic>side chain specificity of amino acid residues</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>KOLASKAR, A.S.</creatorcontrib><creatorcontrib>RAMABRAHMAM, V.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>International Journal of Peptide and Protein Research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>KOLASKAR, A.S.</au><au>RAMABRAHMAM, V.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Side chain characteristic main chain conformations of amino acid residues</atitle><jtitle>International Journal of Peptide and Protein Research</jtitle><addtitle>Int J Pept Protein Res</addtitle><date>1982-01</date><risdate>1982</risdate><volume>19</volume><issue>1</issue><spage>1</spage><epage>9</epage><pages>1-9</pages><issn>0367-8377</issn><eissn>1399-3011</eissn><abstract>Main chain conformation characteristics of the respective side chains of the 20 naturally occurring amino acid residues were obtained by the analysis of (φ, ε)‐data from the crystal structures of 38 different globular proteins. The following observations are of interest: (i) For amino acids other than Glu, Thr and aliphatic amino acids, at least one main chain conformation is stabilised solely by side chain atoms. Such conformations are listed. (ii) In globular proteins, the main chain conformations which are significantly destabilised by side chain atom interactions are observed. The stabilising force for those conformations seems to come from main chain atom interactions. (iii) A set of conformations for which the main chain and side chain interactions are almost equal but in opposite directions, is listed and these conformations will be taken by residues mainly due to the effect of surroundings.
The results can be used to study the folding of polypeptide chains and they also provide an insight into the role of the respective side chains on main chain conformations of amino acid residues.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>7118379</pmid><doi>10.1111/j.1399-3011.1982.tb03016.x</doi><tpages>9</tpages></addata></record> |
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| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Amino Acids Crystallography data analysis Probability Protein Conformation protein crystal structure side chain specificity of amino acid residues |
| title | Side chain characteristic main chain conformations of amino acid residues |
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