The Use of Inhibitors of GABA‐Transaminase for the Determination of GABA Turnover in Mouse Brain Regions: An Evaluation of Aminooxyacetic Acid and Gabaculine

: The accumulation of γ‐aminobutyric acid (GABA) after inhibition of GABA‐T (4‐aminobutyrate: 2‐oxoglutamate aminotransferase, EC 2.6.1.19) by various doses of aminooxyacetic acid (AOAA) and gabaculine was studied in four different regions of the mouse brain. The dose‐response curve for GABA accumul...

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Veröffentlicht in:	Journal of neurochemistry 1982-01, Vol.38 (1), p.57-66
Hauptverfasser:	Bernasconi, R., Maitre, L., Martin, P., Raschdorf, F.
Format:	Artikel
Sprache:	eng
Schlagworte:	4-Aminobutyrate Transaminase - antagonists & inhibitors Acetates - pharmacology Aminooxyacetic Acid - pharmacology Aminooxyacetic acid‐Gabaculine‐Benzodiazepine Animals Brain - drug effects Brain - metabolism Cyclohexanecarboxylic Acids - pharmacology Diazepam - pharmacology Dose-Response Relationship, Drug GABA turnover rate GABA‐transaminase gamma-Aminobutyric Acid - metabolism Male Mice Time Factors Transaminases - antagonists & inhibitors
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