Reasonable surgery for thoracic neuroblastoma in infants and children
Neuroblastoma is the most commonly encountered soft tissue malignant tumor of childhood. Over the past 30 years we have treated 180 patients with neuroblastoma. Sixty-five percent had primary abdominal tumors and 20 percent (41 patients) had primary chest tumors. For the 22 patients under the age of...
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Veröffentlicht in: | The Journal of thoracic and cardiovascular surgery 1978-10, Vol.76 (4), p.459-464 |
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creator | Catalano, PW Newton, WA, Jr Williams, TE, Jr Clatworthy, HW, Jr Kilman, JW |
description | Neuroblastoma is the most commonly encountered soft tissue malignant tumor of childhood. Over the past 30 years we have treated 180 patients with neuroblastoma. Sixty-five percent had primary abdominal tumors and 20 percent (41 patients) had primary chest tumors. For the 22 patients under the age of 2 years, the 2 year survival rate was 87 percent. There were 19 patients who were 2 years of age or older, and of these only seven patients have survived 2 years after the diagnosis was made. The vast majority of these patients were treated with surgery (debulking type procedure) and postoperative radiation and chemotherapy. Patients with the most differentiated tumors had a remarkably good survival rate, with no deaths. However, the tumors with lesser differentiation did not stratify enough focus to draw conclusions as to survival. Staging correlated the least with survival when compared to age or grading. The 2 year survival rates for patients with Stage I, II, III, IV, and IV-S disease were 75, 82, 100, 17, and 80 percent, respectively. In conclusion, 41 cases of documented primary thoracic neuroblastoma are reviewed, with follow-up from 2 to 27 years (average 9.3 years). We have concluded from this experience that age is the main determining factor influencing survival. Heroic and/or radical surgery is contraindicated in this disease. |
doi_str_mv | 10.1016/s0022-5223(19)41071-4 |
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Over the past 30 years we have treated 180 patients with neuroblastoma. Sixty-five percent had primary abdominal tumors and 20 percent (41 patients) had primary chest tumors. For the 22 patients under the age of 2 years, the 2 year survival rate was 87 percent. There were 19 patients who were 2 years of age or older, and of these only seven patients have survived 2 years after the diagnosis was made. The vast majority of these patients were treated with surgery (debulking type procedure) and postoperative radiation and chemotherapy. Patients with the most differentiated tumors had a remarkably good survival rate, with no deaths. However, the tumors with lesser differentiation did not stratify enough focus to draw conclusions as to survival. Staging correlated the least with survival when compared to age or grading. The 2 year survival rates for patients with Stage I, II, III, IV, and IV-S disease were 75, 82, 100, 17, and 80 percent, respectively. In conclusion, 41 cases of documented primary thoracic neuroblastoma are reviewed, with follow-up from 2 to 27 years (average 9.3 years). We have concluded from this experience that age is the main determining factor influencing survival. Heroic and/or radical surgery is contraindicated in this disease.</description><identifier>ISSN: 0022-5223</identifier><identifier>EISSN: 1097-685X</identifier><identifier>DOI: 10.1016/s0022-5223(19)41071-4</identifier><identifier>PMID: 703352</identifier><language>eng</language><publisher>United States: AATS/WTSA</publisher><subject>Abdominal Neoplasms - mortality ; Abdominal Neoplasms - pathology ; Abdominal Neoplasms - surgery ; Adolescent ; Age Factors ; Child ; Child, Preschool ; Female ; Humans ; Infant ; Infant, Newborn ; Male ; Neuroblastoma - mortality ; Neuroblastoma - pathology ; Neuroblastoma - surgery ; Retrospective Studies ; Thoracic Neoplasms - mortality ; Thoracic Neoplasms - pathology ; Thoracic Neoplasms - surgery</subject><ispartof>The Journal of thoracic and cardiovascular surgery, 1978-10, Vol.76 (4), p.459-464</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c381t-3c2e596394b7d297ab74795abe66ec729c53c3a7948c60801b4f246595a708e73</citedby><cites>FETCH-LOGICAL-c381t-3c2e596394b7d297ab74795abe66ec729c53c3a7948c60801b4f246595a708e73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/703352$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Catalano, PW</creatorcontrib><creatorcontrib>Newton, WA, Jr</creatorcontrib><creatorcontrib>Williams, TE, Jr</creatorcontrib><creatorcontrib>Clatworthy, HW, Jr</creatorcontrib><creatorcontrib>Kilman, JW</creatorcontrib><title>Reasonable surgery for thoracic neuroblastoma in infants and children</title><title>The Journal of thoracic and cardiovascular surgery</title><addtitle>J Thorac Cardiovasc Surg</addtitle><description>Neuroblastoma is the most commonly encountered soft tissue malignant tumor of childhood. Over the past 30 years we have treated 180 patients with neuroblastoma. Sixty-five percent had primary abdominal tumors and 20 percent (41 patients) had primary chest tumors. For the 22 patients under the age of 2 years, the 2 year survival rate was 87 percent. There were 19 patients who were 2 years of age or older, and of these only seven patients have survived 2 years after the diagnosis was made. The vast majority of these patients were treated with surgery (debulking type procedure) and postoperative radiation and chemotherapy. Patients with the most differentiated tumors had a remarkably good survival rate, with no deaths. However, the tumors with lesser differentiation did not stratify enough focus to draw conclusions as to survival. Staging correlated the least with survival when compared to age or grading. The 2 year survival rates for patients with Stage I, II, III, IV, and IV-S disease were 75, 82, 100, 17, and 80 percent, respectively. In conclusion, 41 cases of documented primary thoracic neuroblastoma are reviewed, with follow-up from 2 to 27 years (average 9.3 years). We have concluded from this experience that age is the main determining factor influencing survival. Heroic and/or radical surgery is contraindicated in this disease.</description><subject>Abdominal Neoplasms - mortality</subject><subject>Abdominal Neoplasms - pathology</subject><subject>Abdominal Neoplasms - surgery</subject><subject>Adolescent</subject><subject>Age Factors</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Female</subject><subject>Humans</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Male</subject><subject>Neuroblastoma - mortality</subject><subject>Neuroblastoma - pathology</subject><subject>Neuroblastoma - surgery</subject><subject>Retrospective Studies</subject><subject>Thoracic Neoplasms - mortality</subject><subject>Thoracic Neoplasms - pathology</subject><subject>Thoracic Neoplasms - surgery</subject><issn>0022-5223</issn><issn>1097-685X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1978</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkEtLw0AUhQfxVav_QCEr0UV0npnMUkp9QEHwAe6GyeSmTZlk6kyC9N-b2lLhwt185xz4ELoi-I5gkt1HjClNBaXshqhbTrAkKT9AI4KVTLNcfB2i0R45RWcxLjHGEhN1go4lZkzQEZq-gYm-NYWDJPZhDmGdVD4k3cIHY2ubtNAHXzgTO9-YpG6Hq0zbxcS0ZWIXtSsDtOfoqDIuwsXuj9Hn4_Rj8pzOXp9eJg-z1LKcdCmzFITKmOKFLKmSppBcKmEKyDKwkiormGVGKp7bDOeYFLyiPBMDInEOko3R9bZ3Ffx3D7HTTR0tOGda8H3UkhOlqCADKLagDT7GAJVehboxYa0J1ht7-n2jRm_UaKL0nz3Nh9zlbqAvGij3qa2u__1FPV_81AF0bIxzA0z0srNRZpprLhT7BWBvd3c</recordid><startdate>197810</startdate><enddate>197810</enddate><creator>Catalano, PW</creator><creator>Newton, WA, Jr</creator><creator>Williams, TE, Jr</creator><creator>Clatworthy, HW, Jr</creator><creator>Kilman, JW</creator><general>AATS/WTSA</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>197810</creationdate><title>Reasonable surgery for thoracic neuroblastoma in infants and children</title><author>Catalano, PW ; Newton, WA, Jr ; Williams, TE, Jr ; Clatworthy, HW, Jr ; Kilman, JW</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c381t-3c2e596394b7d297ab74795abe66ec729c53c3a7948c60801b4f246595a708e73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1978</creationdate><topic>Abdominal Neoplasms - mortality</topic><topic>Abdominal Neoplasms - pathology</topic><topic>Abdominal Neoplasms - surgery</topic><topic>Adolescent</topic><topic>Age Factors</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Female</topic><topic>Humans</topic><topic>Infant</topic><topic>Infant, Newborn</topic><topic>Male</topic><topic>Neuroblastoma - mortality</topic><topic>Neuroblastoma - pathology</topic><topic>Neuroblastoma - surgery</topic><topic>Retrospective Studies</topic><topic>Thoracic Neoplasms - mortality</topic><topic>Thoracic Neoplasms - pathology</topic><topic>Thoracic Neoplasms - surgery</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Catalano, PW</creatorcontrib><creatorcontrib>Newton, WA, Jr</creatorcontrib><creatorcontrib>Williams, TE, Jr</creatorcontrib><creatorcontrib>Clatworthy, HW, Jr</creatorcontrib><creatorcontrib>Kilman, JW</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of thoracic and cardiovascular surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Catalano, PW</au><au>Newton, WA, Jr</au><au>Williams, TE, Jr</au><au>Clatworthy, HW, Jr</au><au>Kilman, JW</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Reasonable surgery for thoracic neuroblastoma in infants and children</atitle><jtitle>The Journal of thoracic and cardiovascular surgery</jtitle><addtitle>J Thorac Cardiovasc Surg</addtitle><date>1978-10</date><risdate>1978</risdate><volume>76</volume><issue>4</issue><spage>459</spage><epage>464</epage><pages>459-464</pages><issn>0022-5223</issn><eissn>1097-685X</eissn><abstract>Neuroblastoma is the most commonly encountered soft tissue malignant tumor of childhood. Over the past 30 years we have treated 180 patients with neuroblastoma. Sixty-five percent had primary abdominal tumors and 20 percent (41 patients) had primary chest tumors. For the 22 patients under the age of 2 years, the 2 year survival rate was 87 percent. There were 19 patients who were 2 years of age or older, and of these only seven patients have survived 2 years after the diagnosis was made. The vast majority of these patients were treated with surgery (debulking type procedure) and postoperative radiation and chemotherapy. Patients with the most differentiated tumors had a remarkably good survival rate, with no deaths. However, the tumors with lesser differentiation did not stratify enough focus to draw conclusions as to survival. Staging correlated the least with survival when compared to age or grading. The 2 year survival rates for patients with Stage I, II, III, IV, and IV-S disease were 75, 82, 100, 17, and 80 percent, respectively. In conclusion, 41 cases of documented primary thoracic neuroblastoma are reviewed, with follow-up from 2 to 27 years (average 9.3 years). We have concluded from this experience that age is the main determining factor influencing survival. Heroic and/or radical surgery is contraindicated in this disease.</abstract><cop>United States</cop><pub>AATS/WTSA</pub><pmid>703352</pmid><doi>10.1016/s0022-5223(19)41071-4</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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subjects | Abdominal Neoplasms - mortality Abdominal Neoplasms - pathology Abdominal Neoplasms - surgery Adolescent Age Factors Child Child, Preschool Female Humans Infant Infant, Newborn Male Neuroblastoma - mortality Neuroblastoma - pathology Neuroblastoma - surgery Retrospective Studies Thoracic Neoplasms - mortality Thoracic Neoplasms - pathology Thoracic Neoplasms - surgery |
title | Reasonable surgery for thoracic neuroblastoma in infants and children |
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