Encephalitogenic activity of guinea pig myelin basic protein in the SJL mouse
GPBP was shown to be encephalitogenic in SJL mice by direct challenge and in experiments in which an adoptive transfer system was employed. The three fragments obtained by treating GPBP with pepsin were assessed in the same manner. The encephalitogenic activity resided in the C terminal half of the...
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| Veröffentlicht in: | The Journal of immunology (1950) 1982-09, Vol.129 (3), p.1209-1211 |
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| container_title | The Journal of immunology (1950) |
| container_volume | 129 |
| creator | Pettinelli, CB Fritz, RB Chou, CH McFarlin, DE |
| description | GPBP was shown to be encephalitogenic in SJL mice by direct challenge and in experiments in which an adoptive transfer system was employed. The three fragments obtained by treating GPBP with pepsin were assessed in the same manner. The encephalitogenic activity resided in the C terminal half of the molecule (residues 89-169). LNC also proliferated to the same fragment in vitro. Fragments 1-37, and, to a lesser extent, 44-48 stimulated sensitized LNC to proliferate but did not induce disease. |
| doi_str_mv | 10.4049/jimmunol.129.3.1209 |
| format | Article |
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The three fragments obtained by treating GPBP with pepsin were assessed in the same manner. The encephalitogenic activity resided in the C terminal half of the molecule (residues 89-169). LNC also proliferated to the same fragment in vitro. Fragments 1-37, and, to a lesser extent, 44-48 stimulated sensitized LNC to proliferate but did not induce disease.</description><subject>Amino Acid Sequence</subject><subject>Animals</subject><subject>Encephalomyelitis, Autoimmune, Experimental - immunology</subject><subject>Epitopes</subject><subject>Guinea Pigs</subject><subject>Mice</subject><subject>Mice, Inbred Strains - immunology</subject><subject>Myelin Basic Protein - immunology</subject><subject>Peptide Fragments - immunology</subject><issn>0022-1767</issn><issn>1550-6606</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1982</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkE1PwzAMhiMEGmPwCxBST3DqcJq2aY4IjS8NcQDOUZq6baZ-0bRU-_dk2kBYli3Lr19ZDyGXFJYhhOJ2Y-p6bNpqSQOxZK6COCJzGkXgxzHEx2QOEAQ-5TE_JWfWbgAghiCckVlMuXAxJ6-rRmNXqsoMbYGN0Z7Sg_k2w9Zrc68YTYPK60zh1VusTOOlyjpN17cDusnlUKL3_rL26na0eE5OclVZvDj0Bfl8WH3cP_nrt8fn-7u1rxnngx8CZ1mmdciZyFIVIE0gF4iUZwyFTnUkGORxkCR0lzThURozCJFFIDIh2IJc733dI18j2kHWxmqsKtWg-0PykAoBPHFCthfqvrW2x1x2valVv5UU5A6i_IUoHUTJ5A6iu7o62I9pjdnfzYGa29_s96Upysn0KG2tqsqpqZym6Z_TDyBJfNQ</recordid><startdate>198209</startdate><enddate>198209</enddate><creator>Pettinelli, CB</creator><creator>Fritz, RB</creator><creator>Chou, CH</creator><creator>McFarlin, DE</creator><general>Am Assoc Immnol</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198209</creationdate><title>Encephalitogenic activity of guinea pig myelin basic protein in the SJL mouse</title><author>Pettinelli, CB ; Fritz, RB ; Chou, CH ; McFarlin, DE</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c377t-4073ddcc4739dba2e180f9ee17d3e9cbc5930f6288188181875b6304e3509d993</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1982</creationdate><topic>Amino Acid Sequence</topic><topic>Animals</topic><topic>Encephalomyelitis, Autoimmune, Experimental - immunology</topic><topic>Epitopes</topic><topic>Guinea Pigs</topic><topic>Mice</topic><topic>Mice, Inbred Strains - immunology</topic><topic>Myelin Basic Protein - immunology</topic><topic>Peptide Fragments - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pettinelli, CB</creatorcontrib><creatorcontrib>Fritz, RB</creatorcontrib><creatorcontrib>Chou, CH</creatorcontrib><creatorcontrib>McFarlin, DE</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of immunology (1950)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pettinelli, CB</au><au>Fritz, RB</au><au>Chou, CH</au><au>McFarlin, DE</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Encephalitogenic activity of guinea pig myelin basic protein in the SJL mouse</atitle><jtitle>The Journal of immunology (1950)</jtitle><addtitle>J Immunol</addtitle><date>1982-09</date><risdate>1982</risdate><volume>129</volume><issue>3</issue><spage>1209</spage><epage>1211</epage><pages>1209-1211</pages><issn>0022-1767</issn><eissn>1550-6606</eissn><abstract>GPBP was shown to be encephalitogenic in SJL mice by direct challenge and in experiments in which an adoptive transfer system was employed. 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| fulltext | fulltext |
| identifier | ISSN: 0022-1767 |
| ispartof | The Journal of immunology (1950), 1982-09, Vol.129 (3), p.1209-1211 |
| issn | 0022-1767 1550-6606 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_74199078 |
| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Amino Acid Sequence Animals Encephalomyelitis, Autoimmune, Experimental - immunology Epitopes Guinea Pigs Mice Mice, Inbred Strains - immunology Myelin Basic Protein - immunology Peptide Fragments - immunology |
| title | Encephalitogenic activity of guinea pig myelin basic protein in the SJL mouse |
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